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Pierce, John P.; Faerber, Susan; Wright, Fred A.; Rock, Cheryl L.; Newman, Vicky; Flatt, Shirley W.; Kealey, Sheila; Jones, Vicky E.; Caan, Bette J.; Gold, Ellen B.; Haan, Mary; Hollenbach, Kathryn A.; Jones, Lovell A.; Marshall, James R.; Ritenbaugh, Cheryl; Stefanick, Marcia L.; Thomson, Cynthia; Wasserman, Linda; Natarajan, Loki; Thomas, Ronald G.; Gilpin, Elizabeth; Parker, Barbara A.; Greenberg, E. Robert; Al-Delaimy, Wael K.; Bardwell, Wayne A.; Carlson, Robert W.; Emond, Jennifer A.; Hajek, Richard A.; Karanja, Njeri; Madlensky, Lisa (2016). Women's Healthy Eating and Living (WHEL) Study. UC San Diego Library Digital Collections. https://doi.org/10.6075/J0H12ZXW
- Description
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The Women's Healthy Eating & Living (WHEL) Study was an NIH-supported clinical trial. In compliance with the terms and conditions of NIH's Data Sharing Policy as well as to promote the concept of data sharing, these data are being made publicly available. Also in accordance with NIH policy, the datasets include only de-identified data and documentation. All personally identifiable health information such as dates or study sites has been removed in accordance with the HIPAA privacy rule. The Women's Healthy Eating and Living (WHEL) Study was a multisite randomized controlled trial of the effectiveness of a high-vegetable, low-fat diet, aimed at markedly raising circulating carotenoid concentrations from food sources, in reducing additional breast cancer events and early death in women with early-stage invasive breast cancer (within 4 years of diagnosis).
- Date Collected
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- Authors
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- Al-Delaimy, Wael K.
- Bardwell, Wayne A.
- Caan, Bette J.
- Carlson, Robert W.
- Emond, Jennifer A.
- Faerber, Susan
- Flatt, Shirley W.
- Gilpin, Elizabeth
- Gold, Ellen B.
- Greenberg, E. Robert
- Haan, Mary
- Hajek, Richard A.
- Hollenbach, Kathryn A.
- Jones, Lovell A.
- Jones, Vicky E.
- Karanja, Njeri
- Kealey, Sheila
- Madlensky, Lisa
- Marshall, James R.
- Natarajan, Loki
- Newman, Vicky
- Parker, Barbara A.
- Ritenbaugh, Cheryl
- Rock, Cheryl L.
- Stefanick, Marcia L.
- Thomas, Ronald G.
- Thomson, Cynthia
- Wasserman, Linda
- Wright, Fred A.
- Principal Investigator
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- Contributor
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- Methods
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The study randomly assigned 3088 such women to an intensive diet intervention or to a comparison group between 1995 and 2000 and followed them through 2006. Two thirds of these women were under 55 years of age at randomization. This research study had a coordinating center and seven clinical sites. Randomization was stratified by age, stage of tumor and clinical site. A comprehensive intervention program that included intensive telephone counseling, cooking classes and print materials helped shift the dietary pattern of women in the intervention. Through an innovative telephone counseling program, dietary counselors encouraged women in the intervention group to meet the following daily behavioral targets: five vegetable servings, 16 ounces of vegetable juice, three fruit servings, 30 g of fiber and 15-20% energy from fat. Adherence assessments occurred at baseline, 6, 12, 24 or 36, 48 and 72 months. These assessments can include dietary intake (repeated 24-hour dietary recalls and food frequency questionnaire), circulating carotenoid concentrations, physical measures and questionnaires about health symptoms, quality of life, personal habits and lifestyle patterns. Outcome assessments were completed by telephone interview every 6 months with medical record verification. We assessed evidence of effectiveness by the length of the breast cancer event-free interval, as well as by overall survival separately in all the women in the study as well as specifically in women under and over the age of 55 years.
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Doi:
https://doi.org/10.6075/J0H12ZXW
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Creative Commons Attribution 4.0 International Public License
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Use: This work is available from the UC San Diego Library. This digital copy of the work is intended to support research, teaching, and private study.
Constraint(s) on Use: This work is protected by the U.S. Copyright Law (Title 17, U.S.C.). Use of this work beyond that allowed by "fair use" or any license applied to this work requires written permission of the copyright holder(s). Responsibility for obtaining permissions and any use and distribution of this work rests exclusively with the user and not the UC San Diego Library. Inquiries can be made to the UC San Diego Library program having custody of the work.
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Research Data Curation Program, UC San Diego, La Jolla, 92093-0175 (https://lib.ucsd.edu/rdcp)
- Last Modified
2023-06-01