Morris E. Friedkin Papers, 1919 - 1992 (MSS 524)

OFF-SITE STORAGE: COLLECTION STORED OFF-SITE: ALLOW ONE WEEK FOR RETRIEVAL OF MATERIALS
Access: In accordance with state and federal law, materials in Box 3, Folder 18 and Box 24, Folder 12 are restricted until 2067.

Extent: 12.3 Linear feet (26 archives boxes and 16 oversize folders)

Papers of Morris Friedkin, American biochemist, professor and university administrator. His research interests included folic acid metabolism, cancer chemotherapy, enzymology, DNA synthesis, biochemical dynamics of the cell cycle, pharmacology, and positron emission tomography. Materials include laboratory notebooks, loose notes, data, chemical and research product subject files; reprints and typescripts of published and unpublished writings by Friedkin; documents related to grants and fellowships; annotated writings by others; and correspondence. Also included are course materials and notes from Friedkin's time as student at Iowa State College and at University of Chicago; and teaching materials and administrative materials from his time as a faculty member and/or administrator at Washington University, Tufts University, and the University of California, San Diego.

Morris E. Friedkin was born on December 30, 1918, in Kansas City, Missouri. Upon finishing high school in 1936, he entered Kansas City Junior College and received an A.A. in chemistry in 1938. Friedkin continued his education at Iowa State College receiving a B.S. in chemistry in 1940 and an M.S. in analytical chemistry in 1941. After completing his master's degree, he enrolled in the doctorate program in biochemistry at the University of Chicago where he was one of the first graduate students of the renowned biochemist, Albert Lehninger. In 1948, Morris Friedkin completed his Ph.D. with the submission of his dissertation entitled "Studies on Aerobic Phosophorylation." After receiving his doctorate, he continued his studies for one year as a postdoctoral fellow of the National Institutes of Health at the University of Copenhagen.

Friedkin returned to the United States in 1949 and accepted a faculty position in the Department of Pharmacology at the Washington University School of Medicine. In 1957, he joined the faculty of the Department of Pharmacology at the Tufts University School of Medicine where he also served as chair of the department in addition to his teaching and research responsibilities. In 1969, looking to devote more time to research and less to administrative duties, he moved to the Department of Biology at the University of California, San Diego, School of Medicine. For the remainder of his professional career at UCSD except for a short appointment as provost of Revelle College (1974-1976), Friedkin focused exclusively on research and teaching.

Throughout his career, Friedkin worked in many different areas of biochemical research usually with the aim of developing chemotherapies for medicinal application. While attending the University of Chicago, he worked as chemist on the "Penicillin Project" at the Northern Regional Research Laboratory. In 1966, the United States Army contracted with Friedkin to explore new areas in the development of drugs for malaria-resistance. Also in the 1960s, he began his career-long study of cancer chemotherapy with particular interest in the treatment of leukemia. In the course of over forty years of scientific research, Friedkin's contributions advanced scientific understanding in many areas of biochemistry including folic acid metabolism, the biochemical basis of the cell cycle and cell growth, the use of radioactively labeled molecules in biochemical research, molecular pharmacology, DNA synthesis, the structure and function of microtubules, and positron emission tomography. He published regularly in scholarly journals throughout his career and was honored with membership to the National Academy of Sciences in 1978.

Morris Friedkin retired from his position in the Department of Biology at the University of California, San Diego School of Medicine in 1989. He died on September 19, 2002.

The Morris E. Friedkin Papers document the professional career of the American biochemist whose research interests throughout his lifetime included folic acid metabolism, cancer chemotherapy, enzymology, DNA synthesis, the biochemical dynamics of the cell cycle and cell growth, pharmacology, the use of radioactively-labeled molecules in biochemical research, and positron emission tomography. Materials reflecting Friedkin's scientific activities include an extensive but incomplete set of laboratory notebooks, documents related to specific research projects, information Friedkin collected on specific chemicals and laboratory products, loose data, miscellaneous research notes, and descriptions of laboratory techniques. Other materials include documents related to Friedkin's grants and fellowships, correspondence, reprints and typescripts of Friedkin's writings, and manuscripts or typescripts of lectures about his research. Also included are notes and materials from courses Friedkin took as an undergraduate at Iowa State College and as a graduate student at the University of Chicago. Finally, the papers contain materials related to Friedkin's teaching and administrative duties at the Washington University School of Medicine, Tufts University School of Medicine, and the University of California, San Diego, School of Medicine. The papers are arranged in ten series: 1) BIOGRAPHICAL MATERIALS, 2) CORRESPONDENCE, 3) EDUCATION MATERIALS, 4) GRANTS AND FELLOWSHIPS, 5) RESEARCH MATERIALS, 6) WRITINGS BY FRIEDKIN, 7) TEACHING AND ADMINISTRATIVE MATERIALS, 8) WRITINGS BY OTHERS, 9) MISCELLANEOUS MATERIALS, and 10) ORIGINALS OF PRESERVATION PHOTOCOPIES.

Container List

BIOGRAPHICAL MATERIALS

Scope and Content of Series

Series 1) BIOGRAPHICAL MATERIALS: This series, arranged alphabetically, contains materials documenting significant events in Friedkin's life such as his birth certificate, his doctoral diploma, materials regarding his sabbatical leaves, and two personal logs with regular entries.

Box 1 Folder 1
Curriculum vitae, undated
Box 1 Folder 2
Diploma - University of Chicago, 1948
Box 1 Folder 3
Employment materials - United States Department of Agriculture and University of Chicago, 1941 - 1946
Box 1 Folder 4
Kaiser-Permenente Excellence in Teaching Award, 1981 - 1982
Box 1 Folder 5
Letters of Certification from the Iowa State College Registrar, 1940 - 1946
Box 1 Folder 6
Newspaper clippings mentioning Friedkin, 1965 - 1975

Personal logs

Box 1 Folder 7
Notebook containing autobiographical, travel, and lecture notes from the period when Friedkin was at the University of Copenhagen, 1948 - 1949
Box 1 Folder 8
Notebook containing some research related notes but primarily autobiographical journal entries, 1957 - 1989
Box 1 Folder 9
Photograph - Friedkin in front of Geisel Library
Box 1 Folder 10
Sabbatic leaves - Program statements, sabbatical leave reports and correspondence, 1972 - 1988
Box 1 Folder 11
Transcript of birth record, 1919

CORRESPONDENCE

Scope and Content of Series

Series 2) CORRESPONDENCE: Arranged in three subseries: A) Chronological Files, B) A to Z Files, and C) Letters of Recommendation.

A) The Chronological Files subseries is arranged chronologically. The order and content of these files remain unchanged from their original state except that letters of recommendation written for or by Friedkin were seperated and placed into their own folder in the Letters of Recommendation subseries.

B) The A to Z Files subseries, arranged alphabetically by correspondent, contains letters written to or from Friedkin from 1948 to 1987. Included is correspondence with the renowned biochemist and Friedkin's graduate advisor, Albert Lehninger.

C) The Letters of Recommendation subseries contains letters of recommendation, arranged chronologically, written by Friedkin for students, colleagues, and employees. Also included are letters of recommendation written for Friedkin.

Chronological Files

Box 1 Folder 12-16
1951 - 1955
Box 2 Folder 1-2
1956 - 1957
Box 2 Folder 3-8
1982 - 1987

A to Z Files

Box 2 Folder 9
A to L - Miscellaneous, 1948 - 1987
Box 2 Folder 10
M to Z - Miscellaneous, 1948 - 1985
Box 2 Folder 11
Baer, Ed, 1979
Box 2 Folder 12
Bertino, Joseph R., 1963 - 1989
Box 2 Folder 13
Bishop, George - Includes article manuscripts and glass slides, 1958 - 1961
Box 2 Folder 14
Brandt, Sven, 1948
Box 2 Folder 15
Brunsletter, Byron C., 1948
Box 2 Folder 16
Gates, Betsy Jane, 1978 - 1979
Box 2 Folder 17
Grossowicz, Nathan, 1980 - 1982
Box 2 Folder 18
Hoffman-LaRoche Inc., 1979 - 1981

Correspondents: Alan F. Cook, Michael Drzyzga and W. E. Scott.

Box 2 Folder 19
Huennekens, Frank M., 1965 - 1967
Box 2 Folder 20
Kalckar, Herman M., 1948 - 1978
Box 2 Folder 21
Koppelman, Ray, 1963 - 1964

Correspondence with Abel Hoffman is stapled to some of the Koppelman letters.

Box 2 Folder 22
Kornberg, Arthur, 1959 - 1977
Box 2 Folder 23
Lederle Laboratories, 1961 - 1963

Correspondents: Robert B. Angier and E. L. Robert Stokstad.

Box 2 Folder 24
Lehninger, Albert L., 1949 - 1985
Box 2 Folder 25
Lindsley, Dan, 1978 - 1979
Box 2 Folder 26
Livingston, David, 1969 - 1982
Box 3 Folder 1
Lowry, Oliver H., 1949 - 1989
Box 3 Folder 2
Maloney, William F., 1966 - 1968
Box 3 Folder 3
Mathews, Christopher K., 1963 - 1965
Box 3 Folder 4
McQuade, Henry, 1958 - 1975
Box 3 Folder 5
National Institutes of Health, 1952 - 1984

Correspondents: E. P. Cronkite, Irvin Fuhr, Abraham Goldin, Dwijendra K. Misra, Moreshwar Nadkarni, Mary V. Niemic, Kenneth Paull, Frederick Stohlmann, and C. Gordon Zubrod.

Box 3 Folder 6
Plante, Larry, 1988
Box 3 Folder 7
Plowman, Jacqueline, 1984
Box 3 Folder 8
Rizack, Martin A., 1959 - 1960
Box 3 Folder 9
Roche Products Limited, 1983

Correspondents: Frank R. Atherton, C. H. Hassall and N. R. Rogers.

Box 3 Folder 10
Rozengurt, Henry (Enrique), 1979 - 1982
Box 3 Folder 11
Schwarz Laboratories Inc., 1959
Box 3 Folder 12
Silber, Robert, 1962 - 1963
Box 3 Folder 13
Singer, S. Jonathan, 1964
Box 3 Folder 14
Sprinson, David B., 1959
Box 3 Folder 15
Stone, Frederick L., 1948 - 1949
Box 3 Folder 16
Strominger, Jack, 1961 - 1962
Box 3 Folder 17
Unidentified correspondents

Letters of Recommendation

Box 3 Folder 18
1953 - 1987

Restrictions Apply

COLLEGE MATERIALS

Scope and Content of Series

Series 3) COLLEGE MATERIALS: This series, containing education materials, is arranged in three subseries: A) Iowa State College, B) University of Chicago, and C) Stanford University.

A) The Iowa State College subseries, arranged alphabetically, contains materials related to courses Friedkin attended at his undergraduate institution, Iowa State College, from 1939 to 1941. Materials include course notes, laboratory notes, written reports, and course handouts from courses in biochemistry, chemistry, colloid chemistry, and sanitary bacteriology.

B) The University of Chicago subseries, arranged alphabetically, contains materials related to courses Friedkin attended at his graduate institution, the University of Chicago, from 1942 to 1948. Materials include course notes and notebooks, laboratory notes and notebooks, course handout, written assignments, and copies of examinations from courses in biochemistry and genetics.

C) The Stanford University subseries, arranged alphabetically, contains materials from a course in microbiology Friedkin took at Stanford University in 1956. Materials include course notes and notebooks, a poster of microrganisms, and course handouts.

Iowa State College

Box 3 Folder 19
Biochemistry 301, 1941
Box 3 Folder 20
Biochemistry, untitled - Course notes, 1941
Box 3 Folder 21
Chemistry 512 - Course notes and lab materials, 1941
Box 3 Folder 22
Chemistry 519, Microquant - Course notes, 1941
Box 3 Folder 23
Chemistry 531 - Course notes, ca. 1941
Box 3 Folder 24
Colloid Chemistry - Course handouts and notes, 1939
Box 3 Folder 25
Sanitary Bacteriology - Course notes, typescript drafts of assignments and handouts, 1940

University of Chicago

Box 4 Folder 1
Biochemistry 201 - Course handouts and examinations, 1945 - 1946
Box 4 Folder 2-3
Biochemistry 202 - Course handouts, lab materials, notebook, and examinations, 1945 - 1948
Box 4 Folder 4-6
Biochemistry 305 - Course handouts, notebooks, notes and examinations, 1942 - 1948
Box 4 Folder 7-8
Biochemistry 306 - Course notes, handouts, notebook, and examinations, 1946

Genetics 211

Box 4 Folder 9
Course notes, handouts and written assignments, 1945
Box 4 Folder 10
The Unity of Genetics and Biochemistry in Phenylpyruvic Oligophrenia - Typescript, 1945
Box 4 Folder 11
Unidentified course notes, 1950

Stanford University

Introduction to Microbiology

Box 4 Folder 12
Course description and notes, 1956
Box 4 Folder 13 Oversize FB-282-09
Poster, 1956
Box 5 Folder 1-2
Spiral notebooks, 1956

GRANTS AND FELLOWSHIPS

Scope and Content of Series

Series 4) GRANTS AND FELLOWSHIPS: Arranged in two subseries: A) New Antagonists of Amethopterin-Resistant Leukemia and B) Miscellaneous.

A) The New Antagonists of Amethopterin-Resistant Leukemia subseries, arranged chronologically, contains documents related to Friedkin's longest continuous grant from the Department of Health, Education and Public Welfare at the National Institutes of Health for the funding of a project entitled "New Antagonists of Amethopterin-Resistant Leukemia" from 1968 to 1985. Included are grant applications, correspondence, notices of research projects, progress reports, project evaluations, and documents related to Friedkin's subcontracting of SRI International.

B) The Miscellaneous subseries, arranged chronologically, contains materials related to Friedkin's other grants and fellowships. Materials include applications, correspondence, and miscellaneous records from Friedkin's United States Public Health Service postdoctoral fellowship at the University of Copenhagen in 1948 to his application to the University of California, San Diego, for funding of a project entitled "Synthesis of Difluoromethylornithine" in 1988.

New Antagonists of Amethopterin-Resistant Leukemia

Box 5 Folder 3
Progress Reports, 1963 - 1987
Box 5 Folder 4
Correspondence, 1968 - 1987
Box 5 Folder 5
Grant Applications, 1968 - 1984
Box 5 Folder 6
Grant Applications Appendices, 1968 - 1984
Box 5 Folder 7
Notices of Grant Awarded, 1969 - 1985
Box 6 Folder 1
Applications for Continuation Grant, 1970 - 1985
Box 6 Folder 2
Notices of Research Project, 1976 - 1982
Box 6 Folder 3
Project Evaluations, 1977 - 1985
Box 6 Folder 4
SRI International - Project proposal and correspondence, 1980 - 1984

Miscellaneous

Box 6 Folder 5
United States Public Health Service Fellowship - Application, correspondence and progress report, 1948
Box 6 Folder 6
Graduate Training Grant - Applications, progress reports, correspondence, and Tufts University pharmacology graduate program guide, 1960 - 1968
Box 6 Folder 7
Design of New Antifolates for Use in Drug-Resistant Malaria - Application, progress reports, photographs, and related article reprints, 1961 - 1967

Biochemistry of the Transition from Quiescence to Replicative Growth in the Cell Cycle..

Box 6 Folder 8
Guggenheim Fellowship - Application, notes, pamphlets, and correspondence, 1972 - 1978
Box 6 Folder 9
Eleanor-Roosevelt International Cancer Fellowship - Application, notes, correspondence, and progress reports, 1977 - 1979
Box 6 Folder 10
Macy Faculty Scholar Award - Application, notes and correspondence, 1978
Box 6 Folder 11
Role of Cytoplasmic Microtubules in the Regulation of the Activity of Peptide Growth Factors - Applications to the National Science Foundation and American Cancer Society, 1981 - 1983
Box 6 Folder 12
Effects of Amino Acid Phosphonate (APBA) on the Growth of Mouse Leukemic Cells - Application and correspondence, 1984
Box 6 Folder 13
Effects of 2-Amino-4-Phosphono-Butyric Acid on the Growth of L1210 Murine Leukemia Cells from Exponential... - Applications, applications for continuation grant and correspondence, 1985
Box 6 Folder 14
Inhibitory Effects of Phosphono Amino Acids on the G0/G1 Period of Leukemia Cells - Application and correspondence, 1985 - 1988
Box 6 Folder 15
Inhibition of Leukemia Cells by Phosphono Amino Acids - Applications and correspondence, 1985 - 1988
Box 6 Folder 16
Isolation and Identification of CERDLIN (Cation Exchange Resin Derived Leukemia Inhibitor) - Applications, 1986
Box 6 Folder 17
Synthesis of Difluoromethylornithine - Application and notes, 1988

RESEARCH MATERIALS

Scope and Content of Series

Series 5) RESEARCH MATERIALS: Arranged in four subseries: A) Laboratory Notebooks and Notes, B) Projects, C) Chemical and Product Information, and D) Data and Laboratory Techniques.

A) The Laboratory Notebooks and Notes subseries, arranged alphabetically, contains laboratory notebooks and loose research notes from the 1940s to the 1980s. Included are loose notes from short periods during which Friedkin worked at the Brookhaven National Laboratory in the 1950s, 1960s, and 1980s. Also included are laboratory notebooks which Friedkin numbered from the period of his dissertation research at the University of Chicago in the late 1940s to the period of his research at the University of California, San Diego, in the late 1970s. Although the labels on the notebooks are numerically discontinuous, the content of the notebooks are continuous chronologically from 1946 to 1973. Also included are a few unnumbered laboratory notebooks and a folder of miscellaneous research notes.

B) The Projects subseries, arranged alphabetically, contains materials related to specific research projects from 1968 to 1988. Materials include loose research notes, data, graphs, writings by others, and photographs or other illustrations for projects on phosophoserine, cell proliferation, colchine, DNA, folic acid, microtubules, a possible leukemia inhibitor, and thymidylate synthetase.

C) The Chemical and Product Information subseries, arranged alphabetically, contains materials collected by Friedkin concerning chemicals or laboratory products of interest and possibly used in his research. Included are writings by others annotated by Friedkin, notes, and product pamphlets.

D) The Data and Laboratory Techniques subseries, arranged alphabetically, contains materials which are not related to any of the materials in the other RESEARCH MATERIALS subseries. Included are data collected by Friedkin's students and research assistants, data from specific experiments, annotated writings by others on laboratory techniques, and typescripts of laboratory protocols

Laboratory Notebooks and Notes

Box 7 Folder 1
Research notes - Miscellaneous, 1959 - 1988

Brookhaven National Laboratory

Box 7 Folder 2
1957
Box 7 Folder 3
1960 - 1961
Box 7 Folder 4
1962. Sodium Borohydride Tritium Experiments - Notebook, graphs, data tables, and photocopies of writings by others
Box 7 Folder 5
1962 - 1972. Carbon Eleven
Box 7 Folder 6
1986 - 1988
Box 7 Folder 7
Computer notes, 1961
Box 7 Folder 8
Experiments 1 to 186, 1978 - 1979
Box 8 Folder 1
Experiments 373 to 536, 1980 - 1981
Box 8 Folder 2
Experiments 537 to 834, 1981 - 1985
Box 8 Folder 3
Experiments 835 to 1159, 1985 - 1987
Box 9 Folder 1
Metabolic Scenarios I, 1983
Box 9 Folder 2
Methods - Tissue Culture Techniques, 1980 - 1981
Box 9 Folder 3
Northern Regional Research Laboratory - Research notes, ca. 1941 - 1945
Box 9 Folder 4-5
Notebooks, 1986 - 1988

University of Chicago

Box 9 Folder 6
Notebooks 1 - 2, 1946 - 1947
Box 10 Folder 1-2
Notebooks 3 - 6, 1947
Box 10 Folder 3-4
University of Chicago and University of Copenhagen. Notebooks 7 - 10, 1948 - 1949
Box 10 Folder 5-6
University of Copenhagen. Notebooks 11 - 12, 1949

Washington University

Box 11 Folder 1-2
Notebooks 13 - 14, 1949 - 1951
Box 11 Folder 3-4
Notebooks 18 - 19, 1950 - 1952
Box 12 Folder 1-2
Notebooks 23 - 24, 1952 - 1953
Box 12 Folder 3
Notebook 27, 1953 - 1954
Box 12 Folder 4
Notebook 33, 1954 - 1955
Box 13 Folder 1-4
Notebooks 34 - 37, 1955 - 1957
Box 14 Folder 1
Notebook 42, 1957

Tufts University

Box 14 Folder 2-3
Notebooks 43 & 45, 1957 - 1958
Box 14 Folder 4
Notebook 48, 1958 - 1959
Box 15 Folder 1
Notebook 57, 1959 - 1961
Box 15 Folder 2
Notebook 64, 1961 - 1964
Box 15 Folder 3
Notebook 74, 1963 - 1965
Box 15 Folder 4
Tufts University and University of California, San Diego. Notebook 84, 1965 - 1970
Box 16 Folder 1-2
University of California, San Diego. Notebooks 92 & 95, 1970 - 1978

Projects

Cation Exchange Resin Derived Leukemia Inhibitor (CERDLIN)

Box 16 Folder 3
Data and graphs, 1987 - 1988
Box 16 Folder 4
Elemental analysis, ca. 1988
Box 16 Folder 5 Oversize FB-360-01
Infrared spectra - Oversize, ca. 1987
Box 16 Folder 6 Oversize FB-360-02
Oversize, 1987 - 1988
Box 16 Folder 7-8 Oversize FB-360-03
Cell Proliferation Project (L-glutamate, Sodium Butyrate, and Quisqualic Acid) - Data, notes and writings by others, 1982 - 1986
Box 17 Folder 1
Colchine Effects on [3H] Uridine and [3H] Thymidine - Data tables and graphs, 1981
Box 17 Folder 2
Colchine, unidentified data - Data tables, graphs and writings by others, 1968

DNA Profiles

Box 17 Folder 3
Aminoethyl Phosphonate (AEP) Log Cells also Quisqualic Acid and 2-Amino-4-Phosophono-Butyric..., 1985
Box 17 Folder 4
BUdR Staining and Effect of Taurine, 1985
Box 17 Folder 5
Cytofluorometry (Judy Nordberg), 1985
Box 17 Folder 6
Effects of Aminoethyl Phosphonate (AEP), Quisqualic Acid (QQ), and HC (Elizabeth Crawford), 1985
Box 17 Folder 7
Experiment 908 - Effect of Quisqualic Acid on Cell Cycle of L1210, 1986
Box 17 Folder 8
PE, PC and Ethanolamine (Elizabeth Crawford), 1985
Box 17 Folder 9
Quisqualic Acid Experiment (Donna Ruthenmeyer), ca. 1985
Box 17 Folder 10
Sed 3 Experiment, 1985
Box 17 Folder 11
Folic Acid - Correspondence, data, graphs, notes, and protocols, 1961 - 1969
Box 17 Folder 12
Microtubule Theory of Memory - Notes and writings by others, 1974 - 1984

Phosphoserine Project

Box 17 Folder 13
Correspondence - William Colwell, Jac L. Crase, Joe DeGraw, James D. Haug, Alton Meister, Charles H. Stanmer, and Yoshi Tsujita, 1982 - 1984
Box 17 Folder 14
Illustrations, undated
Box 17 Folder 15
Miscellaneous - Includes flyers for lectures, technical information of lab equipment and products and other materials, ca. 1978 - 1984
Box 17 Folder 16
Notes, 1978 - 1984
Box 17 Folder 17
Photographs, Ca. 1978 - 1984
Box 17 Folder 18
Starch Gel Electophoresis, undated
Box 17 Folder 19
Writings by others, 1955 - 1975
Box 17 Folder 20
Thymidylate Synthetase - Amino acid sequences, correspondence, notes, and writings by others, 1971 - 1986

Chemical and Product Information

Box 18 Folder 1
A to Z - Miscellaneous Product Information, 1956 - 1987
Box 18 Folder 2
2-Amino-3-Phosphonopropionic Acid, 1964 - 1984
Box 18 Folder 3
3T3 Cells - Henry (Enrique) Rozengurt publications, 1975 - 1981
Box 18 Folder 4
Bakerbond Chiral Phase Columns - Correspondence, notes and product information, ca. 1984
Box 18 Folder 5
Chemical Library Search Results (American Cancer Society), 1988
Box 18 Folder 6
Chemical requests - Correspondence to or from Friedkin regarding the acquisition of chemicals for research projects, 1953 - 1983
Box 18 Folder 7
Difluoromethane-ornithine - Correspondence, notes and reprint, 1989
Box 18 Folder 8
Dystrophin, 1968 - 1988
Box 18 Folder 9
Fluoronucleotides, 1983 - 1985
Box 18 Folder 10
Hept-6-yne-2,5-diamine, 1983 - 1987
Box 18 Folder 11
Hydra-derived Inhibitors - Notes and photocopies of writings by others, 1983 - 1985
Box 18 Folder 12
Inhibitory Effects of Aminoethyl Phophonate (AEP) - Correspondence with A. F. Isbell, notes and photocopies of writings by others, 1959 - 1985
Box 18 Folder 13
IR and Molecular Ions - Mass spectra and mass chromatagrams, undated
Box 18 Folder 14 Oversize FB-360-04
Laboratory equipment lists - Oversize, 1988
Box 18 Folder 15
Liposomes, 1969 - 1986
Box 18 Folder 16
Ornithine Decarboxylase - Notes and reprints, 1974 - 1988
Box 18 Folder 17
Phthaloylamino Acids - Notes and photocopies of writings by others, 1972 - 1983
Box 18 Folder 18
Phosphonopeptides, 1978 - 1979
Box 19 Folder 1
Rubidium and Sodium Ions, 1975 - 1980
Box 19 Folder 2
Tulp Sedementation Chamber - Graphs, photocopies of writings by others and photographs with negatives, 1980 - 1985

Data and Laboratory Techniques

Box 19 Folder 3
2-Amino-4-Phosphono-Butyric Acid (APBA) - Graphs for poster, undated
Box 19 Folder 4-5 Oversize FB-360-05
Aminophosphonocarboxylic Acid Compounds - Nuclear magnetic resonance spectra and correspondence with Jac L. Crase, 1983
Box 19 Folder 6
Crawford, Elizabeth, Last experiment - Data, graphs and notes, 1987
Box 19 Folder 7
Cronin, Maurin - Data, ca. 1985
Box 19 Folder 8
Diethyl APPA (John Wright) - Data and nuclear magnetic resonance spectra, 1979 - 1985
Box 19 Folder 9
Dimethyl Aminoethyl Phosphonate (AEP) Cyanoborohydride Products - Nuclear magnetic resonance spectra, 1986
Box 19 Folder 10
Experiments 1058, 1065, 1074, 1079,1098 and 1111 - Data, HPLC printouts and spectrographs, 1987
Box 19 Folder 11
Jackson, James - Notes and data, 1980 - 1981
Box 19 Folder 12
L1210 +/- BUDr +/- Aminoethyl Phosphonate (Elizabeth Crawford) - Data, graphs and notes, 1985
Box 19 Folder 13
Organic Synthesis - Notes and photocopies of writings by others, 1941 - 1987
Box 19 Folder 14
Organic Synthesis Techniques (Frank H. Stodola) - Notes and reprints of writings by others, 1942 - 1945
Box 19 Folder 15
Plante (Larry) Compounds - Summary, undated
Box 19 Folder 16
Positron Emission Tomography - Photocopies and reprints of writings by others, 1948 - 1987
Box 19 Folder 17
Procedure for Phosphate Determination, 1977
Box 19 Folder 18
Protocol for the Prepartion of 3T3 Cell Extracts, ca. 1979
Box 19 Folder 19
Proton Magnetic Resonance - Notes and photocopies of writings by others, 1975 - 1988
Box 19 Folder 20
Redistilled Water Room at the Washington University School of Medicine - Drawing and photograph of redistillation apparatus, 1958
Box 19 Folder 21
Resolution of Phosphono Compounds - Notes and photocopies of writings by others, 1979 - 1984
Box 19 Folder 22
Ruthemeyer, Donna - Data Summary, 1985
Box 19 Folder 23
Scintigraphy - Graphs, 1977
Box 19 Folder 24
Thiouracil Deoxyriboside Crystals, ca. 1954
Box 19 Folder 25
Use of Nuclear Magnetic Resonance Instrument at Brookhaven National Laboratory - Notes, 1987
Box 19 Folder 26
X-ray Diffraction of Synthetic and Natural Thymidine - Data and x-ray images, 1953
Box 19 Folder 27
Unidentified research images - Photographs and glass slide from Washington University Department of Illustrations, undated
Box 20 Folder 1
Unidentified research materials - Chromatographs and x-ray films, 1977

WRITINGS BY FRIEDKIN

Scope and Content of Series

Series 6) WRITINGS BY FRIEDKIN: Arranged in three subseries: A) Numbered Publications, B) Lectures, and C) Unnumbered Publications and Unpublished Writings.

A) The Numbered Publications subseries, arranged chronologically, contains reprints, typescript drafts, and drafts of figures for writings published by Friedkin in professional and scholarly journals from 1945 to 1985. Included is a publication list from the collection that lists Friedkin's publications chronologically and numbers them from 1 to 122. The set of numbered publications is incomplete.

B) The Lectures subseries, arranged chronologically, contains materials from lectures Friedkin gave on various biochemical topics at professional conferences or at other universities. Included are miscellaneous lecture announcements and manuscripts or typescripts of his lectures.

C) The Unnumbered Publications and Unpublished Writings subseries, arranged alphabetically, contains reprints or photocopies of published articles that are not on the numbered publication list, manuscripts or typescripts of papers reviewed but not accepted for publication, a typescript copy of Friedkin's dissertation, and other miscellaneous writings.

Numbered Publications

Box 20 Folder 2
Publication list
Box 20 Folder 3-25 Oversize FB-360-06
1945 - 1975
Box 21 Folder 1-12 Oversize FB-360-07-09
1978 - 1986
Box 21 Folder 13
Unidentified negatives of figures, undated
Box 21 Folder 14 Oversize FB-282-10
Unidentified figures - Oversize drawings and photoreproductions, undated

Lectures

Box 21 Folder 15
Announcements - Miscellaneous, 1957 - 1985
Box 21 Folder 16
Studies of Photosynthesis with Isotopes (Denmark) - Lecture typescript with figures, 1949
Box 21 Folder 17
Desoxyranthosine - American Chemical Society (Chicago). Typescript, 1950
Box 21 Folder 18
Enzymatic Synthesis of Thymidine - Lecture schedule, manuscript, figures, and reprints of writings by others, 1951
Box 21 Folder 19
Synthesis of Thymidine - Manuscript, 1951
Box 21 Folder 20
Azguania Nucleosides - Paper presented at the Federation Meeting. Manuscript, 1952
Box 21 Folder 21
[Title unreadable] - Typescript, 1952
Box 21 Folder 22
Untitled - Atlantic City lecture. Manuscript with figures, 1962
Box 21 Folder 23
Biochemical Role of Vitamin B12 in Cellular Proliferation - Typescript of a lecture given by Friedkin at the IX Congresso da Sociedade Europeia de Hematologia, 1963
Box 21 Folder 24
Morris Friedkin, et. al. Two-Enzyme Screen for the Design of New Folate Antagonists - Typescript, ca. 1963
Box 21 Folder 25
Role of Folic Acid in Malaria - Manuscript and typescript, 1968
Box 21 Folder 26
Structure and Function of Microtubules (Harvard University) - Notecards, 1969
Box 21 Folder 27
Study of Folate Analogs (Faculty Seminar at UCSD) - Announcement and manuscript, 1970
Box 21 Folder 28
Untitled (Hadassah Medical School Seminar) - Manuscript, 1978
Box 21 Folder 29
Colchine Seminar - Manuscript, 1980
Box 21 Folder 30
Role of Microtubules - Announcement and manuscript, 1980
Box 21 Folder 31
Untitled lecture notes, ca. 1992
Box 21 Folder 32
Ancient History of Thymidylate Synthetase - Typescript, undated
Box 21 Folder 33
Use of Enzymens in the Design of New Drugs - Manuscript, undated
Box 21 Folder 34
Untitled lecture on cytoplasmic microtubules - Notecards, undated

Unnumbered Publications and Unpublished Writings

Box 21 Folder 35-36 Oversize FB-360-10
Attempted Block of De Novo Serine Biosynthesis by Inhibition of Phosphoserine Phosphatase, 1983
Box 22 Folder 1
Morris Friedkin, et. al. Cell Cycle of L1210 Leukemia Cells is Blocked at G2/M by a Water-Soluable Polymer..., 1988
Box 22 Folder 2
CERDLIN Paper, 1987
Box 22 Folder 3
Class of 1968 - Tufts University School of Medicine Yearbook message, 1968
Box 22 Folder 4
Conservation of Form in Water, 1960
Box 22 Folder 5
Contrasting Styles with the Same Objective: Impressing Students with the Wonder of Life, 1975
Box 22 Folder 6
Crystalline Desoxyribose-1-Phosphate, ca. 1949
Box 22 Folder 7
Effects of 2micromolar Colchicine and 100 Ng/Ml Insulin on Cumulative Uridine Uptake, undated
Box 22 Folder 8
Forty Years - Manuscript of a timeline of Friedkin's major research interests, ca. 1982
Box 22 Folder 9
Friedkin, Morris, et. al. Tritium Isotope Effect During the Enzymic Synthesis of Thymidylate, ca. 1967
Box 22 Folder 10-12 Oversize FB-360-11
Friedkin, Morris and Leslie Wilson. Microtubule Theory of Memory, 1968
Box 22 Folder 13
New Genesis, 1971
Box 22 Folder 14
Pharmacology - Tufts University School of Medicine Yearbook message, 1961
Box 22 Folder 15
Preparation of Carbon-11 Labelled Thymidine, ca. 1962
Box 22 Folder 16
Morris Friedkin, et. al. Process for the Production of 5'-Deoxy-5-[18F] Fluoridine - Patent application and correspondence with Brookhaven National Laboratory, 1983
Box 22 Folder 17
Morris Friedkin and William Schwartz. Projection of Health Science Research Needs for the Tufts-New..., ca. 1958 - 1969
Box 22 Folder 18
Revolution in Pharmacology, 1960
Box 22 Folder 19
Morris Friedkin and Vincent Reid. Role of Folic Acid in Malaria, 1967
Box 22 Folder 20
Rolling in Something Ripe..., 1989
Box 22 Folder 21-23 Oversize FB-360-12
Studies on Aerobic Phosphorylation - Ph. D. dissertation, 1947 - 1948
Box 23 Folder 1
Suggestions for Noah Freidkin (son), 1988
Box 23 Folder 2
Two-Enzyme Screen for the Design of New Folate Antagonists, 1963

TEACHING AND ADMINISTRATIVE MATERIALS

Scope and Content of Series

Series 7) TEACHING AND ADMINISTRATIVE MATERIALS: Arranged in three subseries: A) Washington University School of Medicine, B) Tufts University School of Medicine, and C) UCSD School of Medicine.

A) The Washington University School of Medicine subseries, arranged chronologically, contains mostly course handouts and manuscripts or tyepscripts of lectures for biochemistry or statistics courses taught by Friedkin. Included are photographs of some of the research facilities at Washington University. Both the teaching and administrative materials are arranged chronologically, but they are not interfiled. The teaching materials, arranged chronologically, appear first and any administrative materials follow, also arranged chronologically.

B) The Tufts University School of Medicine subseries, arranged chronologically, contains both teaching and administrative materials. Included are Tufts University School of Medicine yearbooks, a bound collection of articles produced by the faculty of the Department of Biochemistry during Friedkin's time as chair of the department, newspaper clippings, miscellaneous administrative materials, and two folders of miscellaneous laboratory floorplans. Also included are course handouts and typescripts of lectures for courses Freidkin taught at Tufts. Teaching materials, arranged chronologically, appear first in the subseries while any administrative materials, arranged chronologically, follow the teaching materials. The two groups of materials are not interfiled within the subseries.

C) The UCSD School of Medicine subseries is arranged in the same manner as the previous two subseries with the teaching materials, arranged chronologically, followed by the administrative materials, also arranged chronologically. Included are course handouts and lecture manuscripts for biochemistry courses Friedkin taught in the 1970s. Also included are materials related to Friedkin's work as provost of Revelle College (1974-1976), and a restricted file of documents related to Friedkin's role as an investigator of a complaint of scientific misconduct.

Washington University School of Medicine

Box 23 Folder 3
Relationship of Vitamin B12 and the Deoxyribosides - Manuscript of a lecture for a biochemistry seminar, 1949
Box 23 Folder 4
Quantitative Methods in Medicine - Course handouts, lecture manuscripts, examinations, and correspondence, 1950 - 1958
Box 23 Folder 5
Physiology Seminar, B12 and Intrinsic Factors - Notecards and lecture manuscript, 1951
Box 23 Folder 6
Washington University apartment lease, 1950
Box 23 Folder 7
New Cold Room at the Washington University School of Medicine, 1958

Tufts University School of Medicine

Box 23 Folder 8
Elementary Statistical Analysis for Use in Pharmacology - Course handouts and lecture manuscripts, 1960
Box 23 Folder 9
Biology of Macromolecules Course: Learning and Memory - Lecture manuscript, reference list and reprints, 1966
Box 23 Folder 10
Introduction to Biochemistry - Course handouts and lecture manuscript, 1967
Box 23 Folder 11
Administrative documents - Includes Department of Pharmacology documents, Department of Biochemistry documents, A. Warren Stearns building information, and documents regarding Dean Haymen's retirement, 1958 - 1969
Box 23 Folder 12
Nine Good Years - This document is a collection of articles produced by members of the Department of Pharmacology at Tufts University School of Medicine during Friedkin's time as chair of the department, 1958 - 1967
Box 24 Folder 1-2
Yearbooks, 1961 - 1966
Box 24 Folder 3
Tufts-New England Medical Center - Newspaper clippings, 1966
Box 24 Folder 4
Yearbook, 1967

Laboratory floor plans

Box 24 Folder 5
Includes Tufts University Department of Biochemistry floor plan, Tufts University Department of Pharmacology floor plan, and other unidentified floor plans, 1967
Oversize MC-154-04
Includes Tufts University Department of Biochemistry floor plan, blueprint of floor plan for Tufts College Medical and Dental School (194?), and other unidentified laboratory or building floor plans, 1940-1967

UCSD School of Medicine

Box 24 Folder 7
Chemistry 219, Folic Acid Lectures - Lecture manuscripts, lecture schedule, course handout, and examination, 1976
Box 24 Folder 8
Chemistry 269, Folic Acid Lectures - Lecture manuscripts, 1970
Box 24 Folder 9
Carbon Dioxide History for Introduction to Biochemistry 105R - Lecture manuscript, 1976 - 1978
Box 24 Folder 10
Suggestions for the Development of the Biomedical Program at San Diego - Manuscript, notes, correspondence, and newspaper clippings, 1964
Box 24 Folder 11
Provost of Revelle College - Includes notes, typescripts, and letters to parents from the Provost, 1974 - 1976
Box 24 Folder 12
Investigation of scientific misconduct - Includes Morris Friedkin and Suresh Subramani's notes on interviews with parties involved, photocopy of original complaint, correspondence and other related materials, 1992

Restrictions Apply

WRITINGS BY OTHERS

Scope and Content of Series

Series 8) WRITINGS BY OTHERS: This series, arranged alphabetically, contains reprints or typescripts of articles on biochemistry or related topics, many with notations, collected by Friedkin.

Box 25 Folder 1
A - Z - Miscellaneous, 1936 - 1986
Box 25 Folder 2
Bobbs-Merrill Reprint Series in the Life Sciences, 1952 - 1963
Box 25 Folder 3
Drew, Ruth M. and Robert B. Painter. "Action of Tritiated Thymidine on the Clonal Growth of Mammalian Cells", 1958
Box 25 Folder 4
Dicker, Phillip and Enrique Rozengurt. "Synergistic Stimulation of Early Events and DNA Synthesis by...", undated

Friedkin, Noah (son)

Box 25 Folder 5
"Formal Theory of Social Control", undated
Box 25 Folder 6
"Horizons of Observability and the Limits of Informal Control in Intraorganizational...", 1983
Box 25 Folder 7
"On the Origins and Prevalence of the Incest Taboo", undated
Box 25 Folder 8
Hanke, Martin E. Laboratory and Classroom Outline for Hydrogen Ion and Oxidation-Reduction Potentials, 1939
Box 25 Folder 9 Oversize FB-360-13
Huang, Leaf and Richard E. Pagano. "Interaction of Phospholipid Vesicles with Cultured Mammalian Cells", 1975
Box 25 Folder 10
Hughes, W. L. "Chromosomal Replication and the Dynamics of Cellular Proliferation - Some Autoradiographic...", undated
Box 25 Folder 11
Levinson, Joel. "Photography of Anthony Friedkin", 1980
Box 25 Folder 12
Lomax, Nancita R. and V. L. Narayanan. "Chemical Structures of Interest to the Division of Cancer...", 1983
Box 25 Folder 13
Mackay, A. F. "Diazohydrocarbons", 1950
Box 25 Folder 14
Painter, R. B., et al. "Distribution of Tritium-labelled Thymidine in Escherichia Coli During Cell...", 1958
Box 25 Folder 15
Robertson, J. S. and W. L. Hughes. "Intra-Nuclear Irradiation with Tritium-labeled Thymidine", undated
Box 25 Folder 16
Sreevalson, T., et al. "Differential Effect of Interferon on DNA Synthesis 2-deoxyglucose Uptake and...", undated
Box 25 Folder 17
Wilson, Leslie. "Grasshopper Nueroblast Report.", 1965
Box 25 Folder 18
Yorek, Mark A., et al. "Effect of Ethanolamine on Choline Uptake and Incorporation into...", undated

MISCELLANEOUS MATERIALS

Scope and Content of Series

Series 9) MISCELLANEOUS MATERIALS: This series, arranged alphabetically, contains materials unrelated to any other series in the collection. Included are materials documenting Friedkin's attendance at various professional conferences, miscellaneous slides presumably related to Friedkin's lectures, letters Friedkin wrote to politicians concerning the war in Vietnam, newspaper clippings, and documents related to Friedkin's review of the graduate pharmacology program at the University of California, San Francisco.

Box 25 Folder 19
IX Congresso da Sociedade Europeia de Hematologia - Conference program, correspondence and notes, 1963
Box 25 Folder 20
CERDLIN - A Potential Cancer Chemotherapeutic Agent Derived from Commercial Dowx 50 (Cation Exchange Resin) - Record of invention and correspondence, 1986 - 1987
Box 25 Folder 21
Gordon Research Conferences - Includes conference booklets with notes, 1966 - 1968
Box 25 Folder 22
International Convention of Biochemists (Bangalore) - Correspondence, convention materials and abstract of folic acid in malaria research, 1967
Box 26 Folder 1
Malaria Conference (Walter Reed Army Institute of Research) - Correspondence, conference schedule and notes taken by Friedkin at the conference, 1968
Box 26 Folder 2
Kaplan, Nathan O. Memorial materials - Correspondence and reprints of memorial articles from Analytical Chemistry, 1986 - 1987
Box 26 Folder 3
Minutes of the Screening Committee for the California Division (American Cancer Society), 1978
Box 26 Folder 4
Newspaper clippings concerning others, 1965 - 1986
Box 26 Folder 5
Oregon State Seminar - Notes and correspondence, 1973
Box 26 Folder 6
Review of Graduate Pharmacology Program at the University of California, San Francisco - Correspondence, program guides and typescripts of review, 1989
Box 26 Folder 7
Seventh International Congress of Biochemistry (Tokyo) - Correspondence and conference schedule, 1967
Box 26 Folder 8
Slides - Miscellaneous, undated
Box 26 Folder 9
Vietnam - Correspondence, 1966

ORIGINALS OF PRESERVATION PHOTOCOPIES

Scope and Content of Series

Series 10) ORIGINALS OF PRESERVATION PHOTOCOPIES: This series contains the originals of brittle or high acid content documents that have been photocopied.

Box 26 Folder 10
Originals of preservation photocopies