D. Carleton Gajdusek Papers, 1926-1997 (MSS 421)

Restrictions: Video recordings are restricted. Viewing/listening copies may be available for researchers.
Restrictions: Gajdusek's 1995 "Journal of a Year of Disentanglement" is restricted until December 2038 by request of his archives executor.

Extent: 14 Linear feet (35 archives boxes)

The collection contains the papers of D. Carleton Gajdusek, virologist and medical researcher who received the 1976 Nobel Prize in medicine for his discoveries concerning a new mechanism for the origin and dissemination of infectious disease. This research originated as Gajdusek sought to understand kuru, a unique and fatal condition whose victims were among the Fore people of the Eastern Highlands Province of Papua New Guinea.

Daniel Carleton Gajdusek was born in Yonkers, New York, on September 9, 1923. He graduated from the University of Rochester in 1943 before receiving his M.D. from Harvard University in 1946. After residencies at Columbia-Presbyterian Medical Center, Babies Hospital New York, and Children's Hospital Cincinnati, he served as a fellow in pediatrics and infectious diseases at Harvard from 1949-1952. He then served a year as a captain in the Medical Corps at Walter Reed Army Medical Service Graduate School, studying hemorrhagic fever in Korea and in the USSR.

Gajdusek began his Nobel-Prize-winning research in 1955 after holding research positions at Cal Tech, at the Institut Pasteur in Tehran, the University of Maryland, and at the Walter and Eliza Hall Institute of Medicine in Melbourne, Australia. This was the beginning of Gajdusek's decades-long personal and scientific association with the peoples of Papua New Guinea, described in almost daily detail in his journals and in numerous scientific papers and lectures. In Papua New Guinea, Gajudsek co-discovered and provided the first medical description of kuru, a fatal degenerative disorder of the central nervous system unique to the Fore people of the Eastern Highlands Province of that island. Later Gajdusek and others would conclude that the transmission mechanism of kuru originated from the Fore funeral custom of consuming the brains of the deceased. Women and children, kuru's primary victims, were exposed as they prepared and ingested the bodies of infected tribal members.

In 1958, Gajdusek became director of the Study for Child Growth and Development and Disease Patterns in Primitive Cultures, and the Laboratory of Slow, Latent, and Temperate Virus Infections at the National Institutes of Health (NIH) in Maryland. In 1970, he also became chief of NIH's Laboratory of Central Nervous System Studies. While director of these laboratories, Gajdusek also travelled repeatedly back to Papua New Guinea, and around the world, doing additional research and giving lectures and speeches on Kuru and his "slow virus" research.

Gajdusek's long research career at the National Institutes of Health ended in 1996, when he was charged with child abuse. Gajdusek's case never went to trial because he entered a plea agreement that required him to plead guilty to two counts of child abuse, serve nine months in the Frederick County Adult Detention Center (Maryland) and five years probation. Additionally he had to agree not to travel with any unrelated minor. He was permitted to leave the United States and subsequently lived in Europe, continuing to work and edit his yet-to-be published journals, until his death in Norway.

Biographies about Gajdusek include his "Autobiography," (an essay written in 1976 at the time of his Nobel Prize Award) available at http://nobelprize.org/nobel_prizes/ medicine/laureates/1976/gajdusek-autobio.html, Richard Rhodes' story of the discovery and interrelatedness of the transmissible spongiform encephalopathies and prions entitled, Deadly Feasts: Tracking the Secrets of a Terrifying New Plague (New York: Simon and Schuster, 1997), and Warwick Anderson's The Collectors of Lost Souls: Turning Kuru Scientists into Whitemen.

Gajdusek died in December 2008.

Papers of virologist and medical researcher D. Carleton Gajdusek, who researched the causes and transmission of kuru, a neurodegenerative disease found among the Fore people of the eastern highlands of Papua New Guinea, for over four decades. The papers include a broad collection of both Gajdusek's and other scientists' early work on kuru in three bound volumes (1957-1966). Included in the collection are numbered reprints (1957-1996) of Gajdusek's research on the transmissible spongiform encephalopathies (TSEs) and other related subjects; Gajdusek's published and unpublished journals (1955-1996) that chronicle his daily activities during research expeditions throughout the world; and video recordings (1926-1976) and descriptive catalogs, which include footage of people with kuru, as well as other people, activities, and locations in Papua New Guinea. The collection consists solely of photocopied and published materials and does not include any original, handwritten material.

The last series in the collection consists of files related to child abuse charges brought against Gajdusek in 1996 by two of the many children he adopted and brought back to the United States from Papua New Guinea and Micronesia, and his subsequent plea bargain agreement.

The papers are arranged in four series: 1) BIOGRAPHICAL MATERIALS, 2) WRITINGS, 3) VIDEO RECORDINGS, and 4) LEGAL FILES.

Container List

BIOGRAPHICAL MATERIALS

Scope and Content of Series

Series 1) BIOGRAPHICAL MATERIALS: Two bound volumes of Gajdusek's abbreviated and full curriculum vitae, lists of family, friends, adopted children, reprint mailing recipients, archival correspondents, published and unpublished journals, and numbered reprints.

Box 1 Folder 1
Correspondents and mailing lists - Bound photocopies, 1997
Box 1 Folder 2
Curricula vitae, lectures and awards, journals, and bibliography - Bound photocopies, 1997

WRITINGS

Scope and Content of Series

Series 2) WRITINGS. Arranged in three subseries: A) Kuru Collected Writings, B) Reprints, and C) Journals.

A) Kuru Collected Writings: Three bound volumes of papers (1957-1966) by Gajdusek and other scientists documenting the initial discovery, possible causes, and various investigations surrounding kuru, including Igor Klatzo's comparison of Kuru to Creutzfeldt-Jakob disease in humans, William J. Hadlow's letter to the Lancet comparing kuru to scrapie in sheep, investigations of epidemiology, and early consideration of the cannibalism theories of Robert M. and Shirley (now Lindenbaum) Glasse. Each volume begins with a numbered index in chronological order.

B) Reprints: Three bound volumes of Gajdusek's later papers (1980-1985), beginning with a numbered index. Also included are two hundred and thirty-two unbound reprints (1957-1996) by Gajdusek, alone and with others, published both before and after the bound volumes. In all cases the reprints are arranged chronologically by reprint number.

C) Journals: Typescript bound copies of Gajdusek's daily journals from his numerous expeditions around the world. Seventeen of the journals (1955-1970 plus a section of Gajdusek's 1993 journal) are published, and sixteen journals are unpublished (1955-1996). Some of the journals are edited and contain illustrations and photographs.

Kuru Collected Writings

Box 1 Folder 3
#1-52. Papers by Gajdusek and others, 1957-1961
Box 2 Folder 1
#53-103. Papers by Gajdusek and others, 1962-1964
Box 3 Folder 1
#104-162. Papers of Gajdusek and others, 1964-1966

Reprints

Collected Papers of D. Carleton Gajdusek

Box 4
#410-529, 1980-1981
Box 5
#530-627, 1982-1983
Box 6
#628-730, 1984-1985
Box 7 Folder 1
70. Ethnopediatrics as a Study of Cybernetics of Human Development, 1963
Box 7 Folder 2
83. The Composition of Musics for Man Or Decoding from Primitive Cultures the Scores for Human Behavior, 1963
Box 7 Folder 3
90. Factors Governing the Genetics of Primitive Human Populations, 1964
Box 7 Folder 4
142. Drawings by Children in Primitive Cultures, 1969
Box 7 Folder 5
162. Physiological and Psychological Characteristics of Stone Age Man, 1970
Box 7 Folder 6
320.1 Studies of Scrapie in Cell Culture, Cell-Fusing Properties of the Scrapie and CJD Viruses ..., 1977
Box 7 Folder 7
320.2 Simultaneous Density Gradient and Bonding of Scrapie Mouse Brain in Cesium Chloride, Sucrose, ..., 1977
Box 7 Folder 8
325. Urgent Opportunistic Observations: The Study of Changing, Transient and Disappearing Phenomena ..., 1977
Box 7 Folder 9
614. Prologo - Reprint in Spanish, 1983
Box 7 Folder 10
615. Bibliography of Hemorrhagic Fever with Renal Syndrome (Muroid Virus Nephropathy), 1983
Box 7 Folder 11
732. Amyotrophic Lateral Sclerosis and Parkinsonism-Dementia on Guam: A 30-year Evaluation of Clinical ..., 1986
Box 7 Folder 12
739. Pathogenesis of Experimental Hantaan Virus Infection in Laboratory Rats, 1986
Box 7 Folder 13
744. Treponematoses and Tropical Spastic Paraparesis, 1986
Box 7 Folder 14
745. Newer Data on the Inactivation of Scrapie Virus or Creutzfeldt-Jakob Disease Virus in Brain Tissue, 1986
Box 7 Folder 15
747. Newer Data on the Inactivation of Brain Tissue Infected with the Viruses of Scrapie or ..., 1986
Box 7 Folder 16
751. Abnormal Proteins in the Cerebrospinal Fluid of Patients with Creutzfeldt-Jakob Disease, 1986
Box 7 Folder 17
752. Neuropathologic Verification of Creutzfeldt-Jakob Disease in the Exhumed American Recipient of ..., 1986
Box 7 Folder 18
753. Familial Myoclonic Dementia Masquerading as Creutzfeldt-Jakob Disease, 1986
Box 7 Folder 19
754. Intraneuronal Co-Localization of Silicon with Calcium and Aluminum in Amyotrophic Lateral Sclerosis ..., 1986
Box 7 Folder 20
755. Hypothesis: AIDS Encephalopathy is Due to Primary and Persistent Infection of the Brain with ..., 1986
Box 7 Folder 21
760. Histochemical Staining and X-Ray Microanalytical Imaging of Aluminum in Amyotrophic Lateral Sclerosis..., 1986
Box 7 Folder 22
763. On the Uniform Source of Amyloid in Plaques, Tangles and Vascular Deposits, 1986
Box 7 Folder 23
764. Calcium Aluminum Silicon Deposits in Neurons Lead to Paired Helical Filaments Identical to Those ..., 1986
Box 7 Folder 24
766. Transmission of Creutzfeldt-Jakob Disease from Formalin-Fixed, Paraffin-Embedded Human Brain Tissue, 1986
Box 7 Folder 25
769. Chronic Dementia Caused by Small Unconventional Viruses Apparently Containing No Nucleic Acid, 1986
Box 7 Folder 26
770. Bibliography of Viliuisk Encephalomyelitis in the Iakut People of Siberia, 1986
Box 7 Folder 27
776. Isolation, Characterization and Chromosomal Localization of Human Brain cDNA Clones Coding for ..., 1987
Box 7 Folder 28
777. Serological Survey of Prospect Hill Virus Infection in Indigenous Wild Rodents in the USA, 1987
Box 7 Folder 29
779. Characterization and Chromosomal Localization of a cDNA Encoding Brain Amyloid of Alzheimer's Disease, 1987
Box 7 Folder 30
781. Amyloid Gene Duplication in Alzheimer's Disease and Karyotypically Normal Down Syndrome, 1987
Box 7 Folder 31
782. Experimental Scrapie as a Model for Neuroaxonal Dystrophy, 1987
Box 7 Folder 32
783. Cytoskeletal Proteins Forming Amyloid-Like Structures In Vitro, 1987
Box 7 Folder 33
784. Mouse Homolog of the Human Amyloid Beta Protein (AD-AP) Gene is Located on the Distal End of Mouse ..., 1987
Box 7 Folder 34
785. Amyloid of Neurofibrillary Tangles of Guamanian Parkinsonism-Dementia and Alzheimer Disease Share ..., 1987
Box 7 Folder 35
791. Intra-Blood-Brain Barrier Synthesis of Human Immunodeficiency Virus Antigen and Antibody in Humans ..., 1987
Box 7 Folder 36
825. Studies of the CNS in Chimpanzees Persistently Infected with Human Immunodeficiency Virus, 1987
Box 7 Folder 37
826. Tropical Spastic Paraparesis - The Possible Aetiological Role of the Human T-Cell Leukemia/Lymphoma ..., 1987
Box 7 Folder 38
827. Isolation, Characterization and Chromosomal Localization of Human Brain cDNA Clones Coding for ..., 1987
Box 7 Folder 39
828. Immunocytochemical Studies of Neurofibrillary Tangles in Amyotrophic Lateral Sclerosis and ..., 1987
Box 7 Folder 40
829. Polypeptide Sequence of the Neurofibrillary Tangles in Guamanian Parkinsonism-Dementia, 1987
Box 7 Folder 41
833. Transmissible Dementias and Other Brain Disorders Caused by Unconventional Viruses: Relationship ..., 1987
Box 7 Folder 42
834. Virus Infection in Aetiopathogenesis of Motor Neurone Disease: A Hypothesis for a Final Common Path ..., 1987
Box 7 Folder 43
837. Isolation, Characterization, and Chromosomal Localization of a Human Brain cDNA Clone Coding for ..., 1987
Box 7 Folder 44
838. Isolation, Characterization, and Chromosomal Localization of a Human Brain cDNA Clone Coding for ..., 1987
Box 7 Folder 45
839. Extrathecal and Intrathecal IgG Responses to the AIDS Virus LAV/HTLV-III in Experimental Infection ..., 1987
Box 7 Folder 46
840. Induction in Chimpanzees of Antibodies Inhibiting Receptor-Mediated Cell Fusion by HIV Glycoprotein, 1987
Box 7 Folder 47
842. Hemorrhagic Fever with Renal Syndrome: Global Epidemiology and Ecology of Hantavirus Infection, 1987
Box 7 Folder 48
843. Transmissible and Nontransmissible Dementias: Distinction Between Primary Cause and Pathogenic ..., 1988
Box 7 Folder 49
844. Differential Regulation of Amyloid-Beta-Protein mRNA Expression within Hippocampal Neuronal ..., 1988
Box 7 Folder 50
845. Cervical Lymphoblastic Lymphoma in an Aged Guinea Pig, 1988
Box 7 Folder 51
846-847. Alternative cDNA Clones of Amyloid Beta Protein Encode Protease Inhibitor, 1988

Includes "Etiology Versus Pathogenesis: the Causes of Post-Translational Modifications of Host Specified Brain Proteins to Amyloid Configuration."

Box 7 Folder 52
849. Tubulovesicular Structures in Experimental Creutzfeldt-Jakob Disease and Scrapie, 1988
Box 7 Folder 53
850. Biological Properties of Scrapie Agent and Relationship with Scrapie Associated Proteins, 1988
Box 7 Folder 54
851. White Matter Ultrastructual Pathology in Experimental Creutzfeldt-Jakob Disease in Mice, 1988
Box 7 Folder 55
852. Cellular Localization of Messenger RNA Encoding Amyloid-Beta-Protein in Normal Tissue and in ..., 1988
Box 7 Folder 56
854. Tropical Spastic Paraparesis in Colombia, 1988
Box 7 Folder 57
855. Pathological and Immunological Observations on Tropical Spastic Paraparesis in Patients from Jamaica, 1988
Box 7 Folder 58
862. Evidence that DNA is Present in Abnormal Tubulofilamentous Structures Found in Scrapie, 1988
Box 7 Folder 59
865. A New Case of Creutzfeldt-Jakob Disease Associated with Human Growth Hormone Therapy in New Zealand, 1988
Box 7 Folder 60
866. Intracerebral Inoculation of Experimental Animals with Brain Tissue from Patients with Schizophrenia, 1988
Box 7 Folder 61
868. Cycads and Amyotrophic Lateral Sclerosis/Parkinsonism Dementia - Contains author's protest regarding editorial alteration of the original title and second sentence, 1988
Box 7 Folder 62
871. Proteinuria in Monkeys Infected with Prospect Hill Virus, 1988
Box 7 Folder 63
872. Hantavirus Infections in Humans and Commensal Rodents in Singapore, 1988
Box 7 Folder 64
873. High Prevalence Rates of Human T-Lymphotropic Virus Type I (HTLV-I) Infection in Isolated ..., 1988
Box 7 Folder 65
875. Antibodies to HTLV-1 in Populations of the Southwestern Pacific, 1988
Box 7 Folder 66
878. Tropical Myeloneuropathies - a New Aetiology, 1988
Box 7 Folder 67
886. Experimental Models of Metal-Induced Neurofibrillary Degeneration, 1988
Box 7 Folder 68
887. Cellular and Molecular Biology of Neurofibrillary Degeneration in Amyotrophic Lateral Sclerosis and ..., 1988
Box 7 Folder 69
888. Hemorrhagic Fever with Renal Syndrome in Yugoslavia: Detection of Hantaviral Antigen and Antibody ..., 1988
Box 7 Folder 70
891. Histochemical and X-Ray Microanalytical Localization of Aluminum in Amyotrophic Lateral Sclerosis ..., 1988
Box 7 Folder 71
892. Experimental Hantavirus Infection in Nonhuman Primates, 1988
Box 7 Folder 72
893. Hemorrhagic Fever with Renal Syndrome: A Historical Perspective and Review of Recent Advances, 1988
Box 7 Folder 73
894. Comparative Trace-Elemental Study on Amyotrophic Lateral Sclerosis (ALS) and Parkinsonism-Dementia ..., 1988
Box 7 Folder 74
895. Amyloidoses of Brain: Transmissible and Non-Transmissible Dementias, 1989
Box 7 Folder 75
896. Neuronal Degeneration and Neurofilament Accumulation in the Trigeminal Ganglia in Creutzfeldt-Jakob ..., 1989
Box 7 Folder 76
897. Immunocytochemical Characterization of Neurofibrillary Tangles in Amyotrophic Lateral Sclerosis and ..., 1989
Box 7 Folder 77
899. HTLV-I Positive Spastic Paraparesis in a Temperate Zone, 1989
Box 7 Folder 78
901. Comparison of a Human T-Cell Lymphotropic Virus Type 1 Strain from Cerebrospinal Fluid of a ..., 1989
Box 7 Folder 79
904. Nucleus Basalis of Meynert in Parkinsonism-Dementia of Guam: A Morphometric Study, 1989
Box 8 Folder 1
907. HTLV-1 Myeloneuropathy in the Solomon Islands, 1989
Box 8 Folder 2
908. No MSP1 Polymorphism in the Open Reading Frame of the PRP Gene in Patients with Familial Cruetzfeldt..., 1989
Box 8 Folder 3
909. Bone Mass in Guamanian Patients with Amyotrophic Lateral Sclerosis and Parkinsonism-Dementia, 1989
Box 8 Folder 4
910. Scrapie-Induced Diabetes Mellitus in Hamsters, 1989
Box 8 Folder 5
911. Dimethylsulfoxide (DMSO) has No Therapeutic or Prophylactic Effect in Hamsters Inoculated ..., 1989
Box 8 Folder 6
912. Patients with Creutzfeldt-Jakob Disease and Kuru Lack the Mutation in the PRIP Gene Found in ..., 1989
Box 8 Folder 7
913. Interleukin 1 Regulates Synthesis of Amyloid Beta-Protein Precursor mRNA in Human Endothelial Cells, 1989
Box 8 Folder 8
915. Olivopontocerebellar Atrophy in a Large Iakut Kinship in Eastern Siberia, 1989
Box 8 Folder 9
916. Mutations in Familial Cruetzfeldt-Jakob Disease and Gerstmann-Straussler-Scheinker's Syndrome, 1989
Box 8 Folder 10
917. Serial Ultrastructual Studies of Scrapie in Hamsters, 1989
Box 8 Folder 11
922. Brain Amyloidoses: Precursor Proteins and Amyloids of Transmissible and Non-Transmissible ..., 1989
Box 8 Folder 12
929. Early Clinical Kuru Study has Led to Discovery of Unconventional Slow Viruses as Infectious Amyloid ..., 1990
Box 8 Folder 13
930. Coexistence of Creutzfeldt-Jakob Disease and Alzheimer's Disease in the Same Patient, 1990
Box 8 Folder 14
931. Virus Isolation Confirms Serological Data of High Prevalence of HTLV-1 Infection in New Guinea, 1990
Box 8 Folder 15
932. Male Pseudohermaphroditism Caused by 5 Alpha-Reductase Deficiency in the Simtari Anga ..., 1990
Box 8 Folder 16
933. Reevaluation of the Ultrastructual Pathology of Experimental Creutzfeldt-Jakob Disease, 1990
Box 8 Folder 17
934. Resistance of Scrapie Infectivity to Steam Autoclaving After Formaldehyde Fixation and Limited ..., 1990
Box 8 Folder 18
935. Subcellular Distribution and Physicochemical Properties of Scrapie-Associated Precursor Protein ..., 1990
Box 8 Folder 19
936. Scrapie Infectivity and Prion Protein are Distributed in the Same pH Range in Agarose Isoelectric ..., 1990
Box 8 Folder 20
937. Scrapie-Associated Precursor Proteins: Antigenic Relationship Between Species and ..., 1990
Box 8 Folder 21
938. Immunohistochemical Localization of Prion Protein in Spongiform Encephalopathies and Normal Brain ..., 1990
Box 8 Folder 22
939. Models of Environmentally Induced Neurological Disease: Epidemiology and Etiology of Amyotrophic ..., 1990
Box 8 Folder 23
940. Interlukin-1 Immunoreactivity in Primary Rat Cortical Neurons and Astrocytes, 1990
Box 8 Folder 24
941. Spread of Creutzfeldt-Jakob Disease Virus Along Visual Pathways After Intraocular Inoculation, 1990
Box 8 Folder 25
945. Detection of Measles Virus Genomic Sequences in SSPE Brain Tissue by the Polymerase Chain Reaction, 1990
Box 8 Folder 26
947. A Simple and Effective Method for Inactivating Virus Infectivity in Formalin-Fixed Tissue Samples ..., 1990
Box 8 Folder 27
948. Paradoxes of Aspiration for and of Children in Primitive and Isolated Cultures, 1990
Box 8 Folder 28
949. Creutzfeldt-Jakob Disease and Kuru Patients Lack a Mutation Consistently Found in the ..., 1990
Box 8 Folder 29
950 & 957. Identical Mutation in Unrelated Patients with Creutzfeldt-Jakob Disease, 1990

Includes "Mutation in Codon 200 of Scrapie Amyloid Protein Gene in Two Clusters of Cruetzfeldt-Jakob Disease in Siberia."

Box 8 Folder 30
954. PRIP Gene Mutations in Transmissible Spongiform Encephalopathies, 1990
Box 8 Folder 31
955. Molecular Mass, Biochemical Composition and Physicochemical Behavior of the Infectious Form of ..., 1990
Box 8 Folder 32
956. Amyloid of Neurofibrillary Tangles of Guamanian Amyotrophic Lateral Sclerosis Contains Low Molecule ..., 1990
Box 8 Folder 33
958. Conservation of Infectivity in Purified Fibrillary Extracts of Scrapie-Infected Hamster Brain After ..., 1990
Box 8 Folder 34
959. Isolation of HTLV-1 From Members of a Remote Tribe in New Guinea, 1990
Box 8 Folder 35
961. High Prevalence of Human T-Lymphotrophic Virus Type 1 Infection in Isolated Populations in the ..., 1990
Box 8 Folder 36
963. GLI Agenti Di Scrapie - Kuru - CJD - BSE, Quali Polipeptidi Inferttanti: Ipotesi Della Loro Sintesi ... - Reprint in Italian, 1990
Box 8 Folder 37
964. Subacute Spongiform Encephalopathies: Transmissible Cerebral Amyloidoses Caused by Unconventional ..., 1990

Reprint of Chapter 80 from the second edition of Virology, edited by B.N. Fields et al.

Box 8 Folder 38
969. Brain Amyloidoses: Precursor Proteins and the Amyloids of Transmissible and Non-Transmissible ..., 1990
Box 8 Folder 39
970. Raymond Pearl Memorial Lecture, 1989: Cultural Practices as Determinants of Clinical Pathology ..., 1990
Box 8 Folder 40
971. Human T-Lymphotropic Virus Type 1: A Retrovirus Causing Chronic Myeloneuropathies in Tropical ..., 1990
Box 8 Folder 41
973. Modification of Host Precursor Proteins to Amyloid Fibrils in Alzheimer's Disease, 1990
Box 8 Folder 42
974. Dermatoglyphics of the Isolated Kapinganarangese of Micronesia, 1990
Box 8 Folder 43
975. Tropical Spastic Paraparesis and HTLV-1 Associated Myelopathy -- Clinical and Laboratory Diagnosis, 1990
Box 8 Folder 44
977. Temporal Expression of Amyloid Precursor Protein mRNA in Vitro in Dissociated Hippocampal Neuron ..., 1990
Box 8 Folder 45
978. In Situ Hybridization Detection in HTLV-1 RNA in Peripheral Blood Mononuclear Cells of TSP/HAM ..., 1991
Box 8 Folder 46
984. Survival of Scrapie Virus after 3 Year's Interment, 1991
Box 8 Folder 47
989. Characterization of a Variant of Human T-Lymphotropic Virus Type 1 Isolated from a Healthy Member of ..., 1991
Box 8 Folder 48
990. New Mutation in Scrapie Amyloid Precursor Gene (at Codon 178) in Finnish Creutzfeldt-Jakob Kindred, 1991
Box 8 Folder 49
991. Human T-Lymphotropic Virus Type 1 Infection in the Solomon Islands, 1991
Box 8 Folder 50
993. Clinical and Molecular Genetic Study of a Large German Kindred with Gerstmann-Straussler-Scheinker ..., 1991
Box 8 Folder 51
994. Differences in the Membrane Interaction of Scrapie Amyloid Precursor Proteins in Normal and Scrapie ..., 1991
Box 8 Folder 52
995. Verification of HTLV-1 Infection in the Solomon Islands by Virus Isolation and Gene Amplification, 1991
Box 8 Folder 53
997. Detection of Flaviviruses by Reverse Transcriptase Polymerase Chain Reaction, 1991
Box 8 Folder 54
998. Topographic Distribution of Scrapie Amyloid-Immunoreactive Plaques in Chronic Wasting Disease ..., 1991
Box 8 Folder 55
999. A Cluster of Male Pseudohermaphrodites with 5 Alpha-Reductase Deficiency in Papua New Guinea, 1991
Box 8 Folder 56
1000. Detection of Hantavirus RNA in Tissues of Experimentally Infected Mice Using Reverse Transcriptase ..., 1991
Box 8 Folder 57
1003. Retrovirus HTLV-1 en Chile: Estudio en 140 Enfermos Neurologicos - Reprint in Spanish, 1990
Box 8 Folder 58
1004. Increased Multimeric Mitochondrial DNA in the Brain of Scrapie-Infected Hamsters, 1991
Box 8 Folder 59
1007. Highly Divergent Molecular Variants of Human T-Lymphotropic Virus Type 1 from Isolated Populations ..., 1991
Box 8 Folder 60
1009. In Vitro Detection of Cytokines in Mononuclear Cell Cultures from Patients Affected with HTLV-1 ..., 1992
Box 8 Folder 61
1011. Monocyte Macrophage Abnormalities in HTLV-1 Infection, 1992
Box 8 Folder 62
1012. Novel Mutation in the PRNP Amyloid Precursor Gene Co-Segregates with the Creutzfeldt-Jakob Disease ..., 1991
Box 8 Folder 63
1013. A New Mutation (At Codon 178) in the PRNP Amyloid Precursor Gene Co-Segregates with Creutzfeldt ..., 1991
Box 8 Folder 64
1014. Phenotype Expression of Different Mutations in Transmissible Familial Creutzfeldt-Jakob Disease, 1991
Box 8 Folder 65
1015. Creutzfeldt-Jakob Disease Associated with the PRNP Codon 200 LYS Mutation: An Analysis of 45 Families, 1991
Box 8 Folder 66
1016. Familial Creutzfeldt-Jakob Disease in Finland: Epidemiological, Clinical, Pathological and ..., 1991
Box 8 Folder 67
1017. PrP Amyloid Plaques in Creutzfeldt-Jakob Disease of Short Duration: Immunohistochemical Studies of ..., 1991
Box 8 Folder 68
1019. Transmissible Amyloidoses: Genetical Control of Spontaneous Generation of Infectious Amyloid ...", 1991
Box 8 Folder 69
1020. Molecular Genetics of Familial Creutzfeldt-Jakob Disease in France, 1991
Box 8 Folder 70
1021. Transthyretin Amyloidoses of Familial Amyloidotic Polyneuropathy as a Paradigm for the ..., 1991
Box 8 Folder 71
1022. The Life of the Mind, 1991
Box 8 Folder 72
1025. Transmissible Familial Creutzfeldt-Jakob Disease Associated with Five, Seven and Eight Extra ..., 1991
Box 8 Folder 73
1029. Chapter 12: Virologic Studies in Chronic Encephalitis, 1991
Box 8 Folder 74
1036. Neuronal Autophagic Vacuoles in Experimental Scrapie and Creutzfeldt-Jakob Disease, 1992
Box 8 Folder 75
1037. Atypical Creutzfeldt-Jakob Disease in an American Family with an Insert Mutation in the PRNP ..., 1992
Box 8 Folder 76
1039.1 Creutzfeldt-Jakob Disease Cosegregates with the Codon 178 ASN PRNP Mutation in Families of ..., 1992
Box 8 Folder 77
1039.2 Phenotypic Characteristics of Familial Creutzfeldt-Jakob Disease Associated with the Codon 178 ..., 1992
Box 8 Folder 78
1040. Transmission of Spongiform Encephalopathy from a Creutzfeldt-Jakob Disease (CJD) Patient of Jewish ..., 1992
Box 8 Folder 79
1042. Co-Existence of HTLV-1 and HTLV-2 Infection Among the Wayuu Indians of Colombia, 1992
Box 8 Folder 80
1044. Ultrastructual Pathology of Axons and Myelin in Experimental Scrapie in Hamsters and Bovine ..., 1992
Box 8 Folder 81
1045. In Vitro Detection of Cytokines in Mononuclear Cell Cultures from Patients Affected with HTLV-1 ..., 1992
Box 8 Folder 82
1046. Monocyte Macrophage Abnormalities in HTLV-1 Infection, 1992
Box 8 Folder 83
1055. Viliuisk Encephalomyelitis in the Iakut People of Siberia, 1992
Box 8 Folder 84
1055.1 Bibliography of Viliuisk Encephalomyelitis in the Iakut (Sakha) People of Siberia, 1992
Box 8 Folder 85
1057. An Insert Mutation in the Chromosome 20 Amyloid Precursor Gene in a Gerstmann-Straussler- ..., 1992
Box 8 Folder 86
1062. Fatal Familial Insomnia and Familial Creutzfeldt-Jakob Disease: Disease Phenotype Determined ..., 1992
Box 8 Folder 87
1063. Familial Creutzfeldt-Jakob Disease in Chile is Associated with the Codon 200 Mutation of the PRNP ..., 1992
Box 8 Folder 88
1066. Coexistence of Human T-Lymphotropic Virus Type I and II Among the Wayuu Indians from the Guajira ..., 1992
Box 8 Folder 89
1066.1 [?] Human Retroviruses Among Amerindian Populations of Colombia, 1992
Box 8 Folder 90
1068. Lack of JC Viral Genomic Sequences in Multiple Sclerosis Brain Tissue by Polymerase Chain Reaction, 1992
Box 8 Folder 91
1069. Kuru and Scrapie, 1992
Box 8 Folder 92
1070. Genetic Control of De Novo Conversion to Infectious Amyloids of Host Precursor Proteins: Kuru - ..., 1992
Box 8 Folder 93
1071. Scientific Responsibility, 1992
Box 8 Folder 94
1072. Foreword - Reprint from Human Biology in Papua New Guinea: The Small Cosmos, edited by Robert D. Attenborough and Michael P. Alpers, 1992
Box 8 Folder 95
1075. The Molecular Genetics of Human Transmissible Spongiform Encephalopathy, 1992
Box 8 Folder 96
1076. Belgrade Virus: A New Hantavirus Causing Severe Hemorrhagic Fever with Renal Syndrome in Yugoslavia, 1992
Box 8 Folder 97
1080. Real and Imagined Clinicopathological Limits of 'Prion Dementia', 1993
Box 9 Folder 1
1081. Creutzfeldt-Jakob Disease Infectivity of Growth Hormone Derived from Human Pituitary Glands, 1993
Box 9 Folder 2
1084. Long-Term Observations of Human Immunodeficiency Virus-Infected Chimpanzees, 1993
Box 9 Folder 3
1085. Synthetic Peptide Corresponding to Different Mutated Regions of the Amyloid Gene in Familial ..., 1993
Box 9 Folder 4
1088. Tumour Necrosis Factor-Alpha Produces Creutzfeldt-Jakob Disease-Like Lesions in Vivo, 1993
Box 9 Folder 5
1090. IL-2R, CD4 and MHC Class II Antigen Expression by Human T-Cell Leukemia Virus I (HTLV-1) Infected ..., 1993
Box 9 Folder 6
1092. Conformational Transitions, Dissociation, and Unfolding of Scrapie Amyloid (Prion) Protein, 1993
Box 9 Folder 7
1093. Secondary Structure of Proteins Associated in Thin Films, 1993
Box 9 Folder 8
1094. Genetically Distinct Hantavirus in Deer Mice, 1993
Box 9 Folder 9
1095. Genetic Control of Nucleation and Polymerization of Host Precursors to Infectious Amyloids in the ..., 1993
Box 9 Folder 10
1097. A New (Two-Repeat) Octapeptide Coding Insert Mutation in Creutzfeldt-Jakob Disease, 1993
Box 9 Folder 11
1098. Human Retroviruses in Amerindians of Colombia: High Prevalence of Human T Cell Lymphotropic Virus ..., 1993
Box 9 Folder 12
1101. Transmission of Human Spongiform Encephalopathies in Experimental Animals: Comparison ..., 1993
Box 9 Folder 13
1105. Transmissible Amyloidoses of the Brain, 1993
Box 9 Folder 14
1106. The Spongiform Vacuole - the Hallmark of Slow Virus Disease, 1993
Box 9 Folder 15
1107. Astrocytic Changes, 1993
Box 9 Folder 16
1108. Immunohistory of Astrocytic Reaction, 1993
Box 9 Folder 17
1109. Neuroaxonal Dystrophy in Unconventional Slow Virus Disease, 1993
Box 9 Folder 18
1110. The Amyloid Plaque, 1993
Box 9 Folder 19
1112. Tubulovesicular Structures, 1993
Box 9 Folder 20
1116. Neurofibrillary Tangles of Guamanian Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia ..., 1993
Box 9 Folder 21
1118. Molecular Genetic Testing of a Fetus at Risk of Gerstmann-Straussler-Scheinker Syndrome, 1994
Box 9 Folder 22
1119. In Situ PCR: Detection of Persistent and Latent Viruses Within the Central Nervous System, 1994
Box 9 Folder 23
1120. Iatrogentic Creutzfeldt-Jakob Disease: An Example of the Interplay Between Ancient Genes and ..., 1994
Box 9 Folder 24
1122. Attempts to Detect Influenza Virus in Postencephalitic Parkinsonism by In Situ PCR, 1994
Box 9 Folder 25
1123. Fatal Familial Insomnia and Familial Creutzfeldt-Jakob Disease: Different Prion Proteins ..., 1994
Box 9 Folder 26
1127. Autosomal Dominant Spinocerebellum Ataxic (SCA) in a Siberian Founder Population: Assignment to ..., 1994
Box 9 Folder 27
1127.2 [?] Cellular Localization of Poliovirus in the Spinal Cord During Acute Poliomyelitis, 1994
Box 9 Folder 28
1130. Tumor Necrosis Factor Production in HTLV-1 Infected Monocytes/Macrophages, 1994
Box 9 Folder 29
1134. Fatal Familial Insomnia, 1994
Box 9 Folder 30
1135. Cellular Localization of Measles Virus in SSPE by In Situ PCR Enhanced Detection of Widespread ..., 1994
Box 9 Folder 31
1136. Neuronal Cell Death is Not Caused by Apoptosis in CJD, 1994
Box 9 Folder 32
1137. Hot Start Nested Polymerase Chain Reaction In Situ and In Situ Hybridization to Detect Tax Gene ..., 1994
Box 9 Folder 33
1138. Relationship of Microglia and Scrapie Amyloid-Immunoreactive Plaques in Kuru, Creutzfeldt-Jakob ..., 1994
Box 9 Folder 34
1145. R3-R4 Deletion in the PRNP Gene is Associated with Creutzfeldt-Jakob Disease (CJD), 1994
Box 9 Folder 35
1146. Mutation Analysis of Spinocerebellar Ataxia Type 1 (SCA1) in a Large Iakut Kinship of Eastern Siberia, 1994
Box 9 Folder 36
1148. HIV-1 NEF Down-Modulates FC Receptors in Human Monocyte/Macrophage, 1994
Box 9 Folder 37
1152. Human Spongiform Encephalopathy: The National Institutes of Health Series of 300 Cases of ..., 1994
Box 9 Folder 38
1155. Isolation of Pathogenic Hantavirus from White-footed Mouse (Peromyscus leucopus), 1994
Box 9 Folder 39
1156. Nucleating Induction of Infectious Amyloids from Host Precursors, 1994
Box 9 Folder 40
1158. Early Inspiration, 1994
Box 9 Folder 41
1163. Electron Microscopic Findings in Brain of Rocky Mountain Elk with Chronic Wasting Disease, 1994
Box 9 Folder 42
1164. Detection of RNA Virus in Archival Brain Tissue by In Situ RT-PCR Amplification and Labeled-Probe ..., 1994
Box 9 Folder 43
1165. In Situ RT-PCR Amplification in Archival Brain Tissue, 1994
Box 9 Folder 44
1167. Amyotrophic Lateral Sclerosis of Guam: the Nature of the Neuropathological Findings, 1994
Box 9 Folder 45
1171. Neuroaxonal Dystrophy in Experimental Creutzfeldt-Jakob Disease: Electron Microscopical and ..., 1995
Box 9 Folder 46
1172. Creutzfeldt-Jakob Disease with Alzheimer-type A-Beta-Reactive Amyloid Plaques, 1995
Box 9 Folder 47
1174. Cellular Localization of Poliovirus RNA in the Spinal Cord during Acute Poliomyelitis, 1995
Box 9 Folder 48
1175. Prospect Hill Virus: Genetic Diversity and Molecular Phylogeny of an Arvicolid Rodent-Borne Hantavirus, 1995
Box 9 Folder 49
1177. Proliferating Cell Nuclear Antigen Immunohistochemistry in Astrocytes in Experimental ..., 1995
Box 9 Folder 50
1181. Intracerebral Distribution of Infectious Amyloid Protein in Spongiform Encephalopathy, 1995
Box 9 Folder 51
1184. Overexpression of Pro- and Anti-Inflammatory Cytokines by Cultured Keratinocytes from ..., 1995
Box 9 Folder 52
1186. Molecular Phylogeny and Dissemination of Human T-Cell Lymphotropic Virus Type I Viewed Within the ..., 1995
Box 9 Folder 53
1191. Subtle Neurological Signs in 'Asymptomatic' Familial TSP/HAM, 1996
Box 9 Folder 54
96/1. Widespread, Restricted Low Level Measles Virus Infection of Brain in a Case of Subacute Sclerosis ..., 1996
Box 9 Folder 55
96/4. Apoptosis in Glial Tumors as Determined by In Situ Nonradioactive Labeling of DNA Breaks, 1996
Box 9 Folder 56
96/5. Chapter 91 - Infectious Amyloids: Subacute Spongiform Encephalopathies as Transmissible Cerebral ..., 1996

Journals

Box 9 Folder 57
Journals of D. Carleton Gajdusek - Contains typescript photocopies of lists of Gajdusek's published and unpublished journals, 1981-1990
Box 9 Folder 58
Correspondence on the Discovery and Original Investigations on Kuru: Smadel-Gajdusek Correspondence, 1955 - 1958, second printing, 1976 June
Box 10 Folder 1
Kuru Epidemiological Patrols from the New Guinea Highlands to Papua, 1957 August 21- November 10
Box 10 Folder 2
New Guinea journal - Contains laid-in list of journals inscribed to Francis Crick, 1959 June 10-August 15
Box 10 Folder 3
Solomon Islands, New Britain and East New Guinea journal, 1960 January 7-May 6
Box 10 Folder 4
Journal of Expedition in the Libyan Sahara to Kufra, 1960 October 9-November 14
Box 10 Folder 5
Journal of an Expedition to the Western Caroline Islands, 1961 September 4-October 1
Box 11 Folder 1
New Guinea journal, 1961 October 2-1962 August 4
Box 11 Folder 2
Melanesian journal, 1963 February 22-July 23
Box 11 Folder 3
Paraguayan Indian Expeditions to the Guayaki and Chaco Indians, 1963 August 25-September 28
Box 11 Folder 4
Journal of a trip to the Shepherd Banks and Torres Islands and to Espiritu Santo and Efate in the New Hebrides, 1963 November 15-December 25
Box 12 Folder 1
Journal of further explorations in the Kuru Region and the Kukukuku Country, Eastern Highlands of Eastern ..., 1963 December 25-1964 May 4
Box 12 Folder 2
Journal of an expedition to the Western Caroline Islands, 1964 August 26-October 6
Box 12 Folder 3
Melanesian Journal: Expedition to New Hebrides, Solomon Islands, Manus, New Britain and New Guinea - Soft-bound with inscription to Francis Crick, 1965 January 23-April 7
Box 12 Folder 4
Melanesian and Micronesian Journal: Return Expeditions to the New Hebrides, Caroline Islands and New Guinea - Contains laid-in photocopy of partial list of journals, 1965 July 29-December 20
Box 13 Folder 1
South Pacific expedition - With laid-in 1983 list of Gajdusek journals. First blank page contains a stamp, "Prof. F.H.C. Crick - The Salk Institute", 1967 January 26-May 12

This edition was revised and reprinted with an index and illustrations in September 1982.

Box 13 Folder 2
Colombian expeditions to the Noanama, Cofan and Ingano Indians, 1970 August 22-September 14
Box 13 Folder 3
Sections of the 1993 Journal of D. Carleton Gajdusek Relating to Studies of Kuru, Population Genetics and Male Pseudohermaphroditism in Papua New Guinea - and - Rediscovery of Persistent High Incidence Amytrophic Lateral Sclerosis/Parkinsonism Dementia in West New Guinea (Irian Jaya, Indonesia), 1993
Box 14 Folder 1
Australia and New Guinea journals, 1955 October-1957 December 31
Box 14 Folder 2
Melanesian, Indonesian, and Malaysian expedition, 1975 November 16-1976 May 11
Box 14 Folder 3
Stumbling Along the Tortuous Road to Unanticipated Nobility. Melanesian, Indonesian, and Malaysian Expedition; Viliuisk Encephalitis in Iakut Siberians; Sojourns with Royalty, 1975 November 16-1976 December 31
Box 15 Folder 1
Journal of a Flight from Nobility in an Attempt, in Latin America and French East Africa, to Recover from..., 1977 February 21-April 28
Box 15 Folder 2
Western Pacific journal, 1978 January 4-September 23
Box 15 Folder 3
Journal of a Year of Travels and Medical Investigations..., 1982
Box 15 Folder 4
China Journal With a Circuit Through New Zealand, Australia, Papua New Guinea, Hawaii, and Geneva and Two..., 1983 January 4-April 30
Box 15 Folder 5
Duodeca Log: Journal of Twelve Departures From and Return to Prospect Hill, 1988
Box 16 Folder 1
Decline and Fall of Prospect Hill: The End of a Decade of Manorial Living, 1989
Box 16 Folder 2
Year of Reentrenchment in a Wonderland of Infectious Amyloids, 1990
Box 17 Folder 1
Except for Happiness at Rainbow's End, 1991
Box 17 Folder 2
Studies of Mind, Brain, Sex, and Language: From Tropics to Arctic on Two Hemispheres, 1992
Box 18 Folder 1
Journal of a Year of Disenchantment, 1994
Box 18 Folder 2
Journal of a Year of Disentanglement, 1995

Restricted until December 2038.

Box 18 Folder 3
Regaining Equanimity, 1996
Box 19 Folder 1
Ascent to the Zenith Was Magnificent; Denouement Was a Bit Difficult, Part I: Descent to Inferno, 1996 January 1-April 16

VIDEO RECORDINGS

Scope and Content of Series

Series 3) VIDEO RECORDINGS: VHS transfers of original clinical demonstration and research films pertaining to Gajdusek's work in Papua New Guinea. The series begins with the five-volume catalog of the Central Nervous System Studies Laboratory (CNSSL) Medical Ethnographic Film Archives. Many of the films described in the catalog are included in this series. The folder descriptions for films represented in the catalog include their corresponding catalog numbers. The videorecordings include all 25 parts of Kuru: A Comprehensive Assembly of All Known Kuru Cinema of Clinical Aspects of Kuru. The series contains a 1970 reprint by Gajdusek that details the first seventeen reels of Kuru film, and includes a table listing the filmers, dates of filming, footage length, and number of Kuru patients filmed. The series also includes Parts 1-3 and 6-7 of Nutrition of the Fore People of New Guinea. In addition to films directly related to Gajdusek's research, the series includes narrated film documenting Matthew W. Stirling's 1926-1927 expedition to New Guinea. Materials in the series are arranged alphabetically by title and are restricted for preservation.

Catalog of the CNSSL Medical Ethnographic Film Archives, 1996 edition

Box 20 Folder 1
Volume 1. Research Films (1957-1965)
Box 20 Folder 2
Volume 2. Research Films (1966-1978)
Box 21 Folder 1
Volume 3A-B. Deposited Research Films, Special Research Films, and Demonstration Films
Box 21 Folder 2
Volume 4. Supplement
Box 21 Folder 3
Volume 5. Master List of Films (Volume 1-4) and Supplemental Index of Films Not Described or Listed in Volumes 1-4
Box 22 Folder 1-2
Asmat Skills, parts 1 & 2
Box 22 Folder 3
Asmat Tjitak
Box 22 Folder 4
Clinical Demonstrations
Box 23 Folder 1
Exploration of the Kuru Region. People of the Kuru Region, 1957 March 1- 1958 February
Box 23 Folder 2-3
Kukukuku; Moraei, Simbari, Bulaki, Usirampia, Iambananye, Amdei, Kamal Yanapa, Hakwangi; Exploratory Patrol... Parts 1 & 2, 1962 April 29-May 15
Box 23 Folder 4
A Comprehensive Cinema Record of Disappearing Kuru - Reprint detailing the filming of the first 17 reels of Kuru Films. Includes a table of filmers, dates of filming, footage length and number of Kuru patients filmed, 1970

Kuru: A Comprehensive Assembly of All Known Kuru Cinema of Clinical Aspects of Kuru, 1957-1964

Box 24 Folder 1-4
Parts 1-4
Box 25 Folder 1-4
Parts 5-8
Box 26 Folder 1-4
Parts 9-12
Box 27 Folder 1-4
Parts 13-16
Box 28 Folder 1
Part 17

Kuru: A Comprehensive Assembly of All Known Kuru Cinema of Clinical Aspects of Kuru, 1967-1976

Box 28 Folder 2-4
Parts 18-20
Box 29 Folder 1-4
Parts 21-24
Box 30 Folder 1
Part 25
Box 30 Folder 2
Longlong Behavior: Ritual Clownings as a Socially Accepted Pattern of Behavior Disorder, produced and filmed by E.R. Sorenson and D.C. Gajdusek, 1961-1964
Box 30 Folder 3-4
Moraei and Munriri Kukukuku; Ethnopediatric Study, Eastern Highlands, Territory of Papua and New Guinea - Part 1, cans A & B, 1962 January 2-26
Box 31 Folder 1
Moraei and Munriri Kukukuku; Ethnopediatric Study, Eastern Highlands, Territory of Papua and New Guinea - Part 2, 1962
Box 31 Folder 2-3
Moraei and Munriri Kukukuku, Yar-Pawaian, and South Fore; Child Study and Medical and Epidemiological... Parts 1 & 3, 1963 April 7-30

Nutrition of the Fore People of New Guinea, 1959-1964

Box 31 Folder 4
Part 1
Box 32 Folder 1-4
Parts 2-3, 6-7
Box 33 Folder 1-2
Parts 8-9
Box 33 Folder 3-4
Stirling New Guinea Expedition - Parts 1 & 2, 1926-1927
Box 34 Folder 1
Stirling New Guinea Expedition - Parts 3, 4A & 4B
Box 34 Folder 2
Yagwalye, Iwaia, Hakwangi; The Kukukuku Peoples of the Menyamya Region, East New Guinea, 1960 May

LEGAL FILES

Scope and Content of Series

Series 4) LEGAL FILES: Gajdusek's personal documentation regarding the charges of child molestation brought against him in 1996. The material consists of photocopies of letters and petitions of support from scientists, Papua New Guinean and Micronesian children who lived with him and some of whom were adopted by him, and other citizens and officials of Papua New Guinea. These documents were used to initially support Gajdusek against the charges and later to help convince the judge to accept the plea agreement the parties had negotiated. Also included is correspondence relating to the plea agreement that he entered with the State of Maryland, the United States Attorney's concurrence, an FBI memorandum of an interview with a former scientific colleague who reported his suspicions regarding possible child abuse, press clippings, and documentation of his scientific contributions.

Historical Record of the Prosecution, Trial, and Defense of D. Carleton Gajdusek

Box 35 Folder 1-4
Folios I - IV, 1996
Box 35 Folder 5-6
Folio V, parts 1 & 2, 1997