Robert N. Hamburger Papers, 1950 - 1992 (MSS 0232)

Restrictions: Laboratory notebooks and research files containing medical records are restricted until the year 2067. Files containing administrative files are restricted until 2084.

Extent: 16 Linear feet (41 archives boxes)

Papers of Robert N. Hamburger, UCSD professor of pediatrics and researcher in allergy and immunology. Hamburger investigated the relationship between peptides and immunoglobulin E (IgE) antibodies and synthesized human IgE pentapeptide (HEPP), a substance shown to inhibit allergic response. Included in the collection are laboratory notebooks (1960-1984), extensive research files on Hamburger's allergy studies, correspondence, and Food and Drug Administration documents related to animal and human testing. Also included are business files related to Allergy Peptide Company, Inc. (APCo, Inc.); Cytotech, Inc.; Immunetech, Inc.; Immunetech Research Partners; and Syntex Corporation, biotechnology firms that attempted to develop HEPP as a commercial product. The collection also contains biographical materials, writings, lectures, correspondence, and materials related to Hamburger's involvement in professional organizations. The later accessions include UCSD administrative documents including committtee materials and documents related to the history of the School of Medicine.

Robert N. Hamburger was born in New York on January 26, 1923. He received his B.A. in zoology and chemistry in 1947 from the University of North Carolina and attended Yale University School of Medicine (1947-1951), where he conducted research on LE cells. Hamburger carried out his medical residency at Strong Memorial Hospital in Rochester, N.Y., and Yale University School of Medicine. Between 1960 and 1963, as a Special Fellow of the National Institutes of Health, he studied molecular genetics and immunology in the UCSD Department of Biology. In 1964, he was appointed associate professor of pediatrics at the UCSD School of Medicine and served as its Assistant Dean for Faculty and Curriculum Affairs (1964-1969). In 1967, during a six-month semi-sabbatical at Guy's Hospital Medical School, London, he studied the development of immunologic systems in the human newborn. Hamburger was appointed head of the Pediatric Immunology and Allergy Division of the UCSD School of Medicine in 1969.

Hamburger's laboratory research with immunoglobin E (IgE) during the early 1970s led to the synthesis of a peptide, human immunoglobin E pentapeptide (HEPP), that inhibited allergic reaction in a limited "in vivo" test. He published his findings in an article in Science (August 1, 1975) entitled "Peptide Inhibition of the Prausnitz-Kustner Reaction." The University of California obtained two patents for HEPP: "Polypeptide Agents for Blocking the Human Allergic Response" (1976) for the peptide, and "Method for Blocking Allergic Response" (1979) for a method of delivery. In March of 1977, amid optimism over HEPP's potential as a cure for allergy sufferers, Syntex Corporation, a Palo Alto biotechnology firm, bought the rights and a two year research option to develop HEPP as a product. Syntex dropped the project after a year and a half when no suitable test animal could be found to replicate human response. In 1978, Hamburger entered into an option agreement with the University of California and formed APCo, Inc. (Allergy Peptide Company, Inc.), with the purpose of advancing his research through the first stages of FDA approval.

In 1981, Hamburger and UCSD doctors Richard O'Connor and Gary Hahn formed Immunetech Research Partners to finance further stages of the peptide research. This partnership purchased the assets of APCo, Inc., including all of its research materials and, signed a research and development agreement with Immunetech, Inc., a separate company formed with venture capitalist Ray McKewon of the Enterprise Management Company. Immunetech, Inc., then purchased both UC-owned patents and attempted to develop HEPP as a product but eventually dropped the project. Hamburger was the first executive vice president of Immunetech, Inc., and was involved in research and development until 1985.

Robert Hamburger retired from UCSD in 1990 as emeritus professor and continues to conduct private research and development activities.

The Robert Hamburger Papers document allergy and immunology research in Hamburger's laboratory at UCSD and the development of human IgE pentapeptide (HEPP). The collection contains laboratory notebooks (1960-1984), research materials on Hamburger's peptide studies, FDA documents, patent and grant material, and writings by Hamburger and others. Also included are business records and agreements with: APCo, Inc.; Cytotech, Inc.; Immunetech, Inc.; Immunetech Research Partners; Enterprise Management Company; and Syntex Corporation, biotechnology firms associated with the development of HEPP. Other materials include UCSD administrative files and development documents for the School of Medicine.

SERIES 1: BIOGRAPHICAL MATERIAL

The BIOGRAPHICAL MATERIAL series contains directory entries, Hamburger's curriculum vitae, news clippings, photographs, correspondence from his sabbatical leave at Guys Hospital, London, a journal of medical notes from Strong Memorial Hospital, and material from Yale University's 25th Class Reunion Symposium .

SERIES 2: RESEARCH MATERIAL

The RESEARCH MATERIAL series constitutes the bulk of the collection and is arranged in four subseries: A) Laboratory Notebooks, B) Laboratory Subject Files, C) Patent Files, and D) Grant Files.

A) The Laboratory Notebooks subseries contains laboratory research data compiled at UCSD by Hamburger, his colleagues and graduate students from 1960-1984. The notebooks contain lupus studies, immune kill studies, immunoglobulin E (IgE) and diphtheria assays, lymphocyte transformation studies, and peptide research data. The notebooks are arranged chronologically. The majority of notebooks in this series contain medical records and are restricted.

B) The Laboratory Subject Files (1962-1989) subseries contains laboratory notes, general laboratory correspondence, FDA correspondence, and FDA documents. Research contained in this subseries was conducted primarily at UCSD; however, some clinical trials where carried out at other institutions and, in some cases, sponsored by private firms including APCo, Inc., Immunetech, Inc., and the Schering Corporation. The majority of data in this subseries consists of peptide studies and HEPP (human IgE pentapeptide) trials on animals and humans, including subcutaneous testing, toxicology tests, ophthalmic solution testing, and intranasal solution tests. Other studies include Albuterol research, diphtheria-tetanus tests and a twin study. The files are arranged chronologically.

C) The Patent Files subseries is arranged chronologically and contains patent-related correspondence (1974-1986), agreements between the University of California and APCo, Inc., and drafts of Hamburger's two patents entitled "Polypeptide Agents for Blocking the Human Allergic Response" (1976) and "Method for Blocking Allergic Response" (1979).

D) The Grant Files subseries contains documentation of research grants from the National Institutes of Health (1962-1979) and the University of California, San Diego (1965 and 1977). Also included is one unfunded grant proposal to the American Cancer Society (1969).

SERIES 3: WRITINGS BY HAMBURGER

This series, which includes a bibliography of Hamburger's writings, is arranged in three subseries: A) Abstracts and Reprints, B) Talks and Lectures and C) Book Reviews for Journals.

A) The Abstracts and Reprints subseries is arranged alphabetically by title and contains materials dated 1950-1986. Included are draft chapters 1-10 of an unpublished book entitled "Pediatric Immunology and Allergy" and writings on passive immune kill, immunoglobulin E (IgE) and other immunology and allergy-related topics.

B) The Talks and Lectures subseries is arranged alphabetically by title and contains materials dated 1965-1983. Presented at various meetings and classes, materials include manuscript drafts, typescripts, lists of slides, and some correspondence. Lecture topics include immunoglobulin E (IgE), human IgE pentapeptide (HEPP) and other research associated with allergy and immunology.

C) The Book Reviews for Journals subseries is arranged alphabetically by title of journal and contains book reviews by Hamburger for Annals of Allergy, Journal of Allergy and Clinical Immunology, Journal of Laboratory and Clinical Medicine, and Science. Materials in this series, which include correspondence, are dated 1977-1985. SERIES 4: WRITINGS OF OTHERS

This series is arranged alphabetically by author and includes writings by other authors that Hamburger annotated.

SERIES 5: BIOTECHNOLOGY DEVELOPMENT FIRMS

This series documents the participation of biotechnology and investment firms in developing HEPP as a commercial product and is arranged in six subseries: A) APCo. Inc. (Allergy Peptide Company, Inc.); B) Cytotech, Inc.; C) McKewon and Timmons Investment Bankers; D) Immunetech, Inc.; E) Immunetech Research Partners; and, F) Syntex Corporation.

A) The APCo, Inc. (Allergy Peptide Company, Inc.), subseries is arranged alphabetically and contains business documents and correspondence from its establishment in 1978 by Robert Hamburger through its dissolution in 1982. For APCo, Inc., sponsored research studies see Series 2. RESEARCH MATERIAL.

B) Cytotech, Inc., is arranged alphabetically and contains Hamburger's consulting and shareholder materials, including reports, business documents and correspondence dated 1981-1988.

C) McKewon and Timmons Investment Bankers is arranged alphabetically and contains correspondence and shareholder materials dated 1983-1987. Prior to McKewon and Timmons, Ray McKewon was affiliated with the Enterprise Mangement Company, which was involved in business agreements with Immunetech, Inc., and Immunetech Research Partners. Those materials are located in the following two subseries.

D) Immunetech, Inc., is arranged alphabetically and contains business agreements, correspondence, financial reports, meeting agendas, meeting minutes, and shareholder materials dated 1976-1992. Materials dated 1981 to 1985 reflect Hamburger's primary involvment with this company, including its establishment and initial business negotiations. For Immunetech, Inc., sponsored research studies see Series 2. RESEARCH MATERIAL.

E) Immunetech Research Partners is arranged alphabetically and contains business agreements and shareholder materials dated 1981-1982. Most of these materials document the first year of this partnership (1981) between Robert Hamburger, Richard O'Connor and Gary Hahn.

F) Syntex Corporation is arranged alphabetically and contains a consulting agreement with Hamburger, a license agreement with the University of California Regents and a press release regarding the company, all of which are dated 1976. For Syntex Corporation sponsored research studies see Series 2. RESEARCH MATERIAL.

SERIES 6: PROFESSIONAL ORGANIZATIONS

Arranged alphabetically, this series contains correspondence, committee rosters and meeting materials for professional organizations in which Hamburger participated. Among the organizations represented are: the American Academy of Allergy and Immunology; the American Academy of Pediatrics; the American College of Allergy and Immunology; the California Medical Association; the Nuffield Foundation; the San Diego County Medical Society; and, the Western Society for Pediatric Research.

SERIES 7: UCSD GENERAL CAMPUS

The UCSD GENERAL CAMPUS files are documents pertaining to subjects relating to the administration of the campus and how they relate to the School of Medicine. Subjects include building of the campus, development of academic programs, the activities of individual departments and institutes, and committees Hamburger participated in, at the campus and systemwide levels. The files are arranged alphabetically.

The series also includes Hamburger's files on the UCSD Chamber Music Series. The files, labeled "Quartet Series," detail Hamburger's involvement in beginning, planning, and supporting the series. Materials include correspondence, programs, notes, planning documents, tickets, and clippings for the series that has evolved into UCSD's ArtPower! Chamber Music Series.

SERIES 8: UCSD SCHOOL OF MEDICINE

The materials of the UCSD SCHOOL OF MEDICINE, arranged alphabetically, are administrative and developmental files documenting Hamburger's involvement with committees, curriculum, residency training, and the Basic Medical Sciences building advisement. Included are several folders pertaining to the history of the school of medicine with interviews, events, and planning.

SERIES 9: ORIGINS OF THE SCHOOL OF MEDICINE AT UCSD

Documents include the correspondence and typescripts for the UCSD School of Medicine memoir, Origins of the School of Medicine at UCSD , written by Robert Hamburger and the one day symposium (November 1, 1984) transcript drafts and correspondence. The personalized history document honored both the 25th Anniversary of the founding of UCSD and the 20th Anniversary of the School of Medicine. Participants of the symposium included Herbert York, Clark Kerr, Roger Revelle, John Galbraith, Robert Hamburger, and Joseph Stokes.

Container List

BIOGRAPHICAL MATERIAL

Box: 1 Folder: 1
Biographical materials published in various directories, 1965 - 1968
Box: 1 Folder: 2
Committee service lists, 1966 - 1968
Box: 1 Folder: 3
Curriculum vita, 1981
Box: 1 Folder: 4
News clippings, 1965 - 1985
Box: 1 Folder: 5
Photographs of Robert N. Hamburger, 1975
Box: 1 Folder: 6-7
Sabbatical correspondence, A-Z, 1967
Box: 1 Folder: 8
Strong Memorial Hospital journal of medical notes, 1952 - 1953
Box: 1 Folder: 9
Yale University 25th Reunion Class Symposium, 1976

RESEARCH MATERIAL

Laboratory Notebooks

Box: 2 Folder: 1
1960 October 23 - September 28: Workbook
Box: 2 Folder: 2-3
1961-1963: Auto Ab and Lupus Studies
Box: 2 Folder: 4-6
1962: Hela H and R Study, raw data
Box: 2 Folder: 7
1963 January 28 - June 18: Hela H and R Immune Kill Study, raw data - Book II
Box: 2 Folder: 8
1963 August 26 - 1964 May 30: Passive Immune Kill - Book III
Box: 3 Folder: 1
1966 February 8 - December 14: Book VIII - Robert Hamburger and J. Douglass

Restrictions Apply

Box: 3 Folder: 2
1966 December 13 - 1967 November 7: UCSD School of Medicine - R. Hamburger and J. Douglass

Restrictions Apply

Box: 3 Folder: 3
1967 July 1 - December 15: Book I - Robert Hamburger

Restrictions Apply

Box: 3 Folder: 4
1968 December 19 - 1969 July 23: Antibody Binding Extracorporeal, Book I - Michael Bazaral
Box: 3 Folder: 5
1970 July 10 - 1972 June: Hemagglutination Assay/Thyroglobulin Immunoabsorbtion - Michael Slaughter

Restrictions Apply

Box: 3 Folder: 6
1970 August 27 - 1971 March 4: Immunoglobin Assays - M. Bazaral, R. Hamburger and H. A. Orgel

Restrictions Apply

Box: 4 Folder: 1
1970 December 2 - 1972: Twin Study ledger book

Restrictions Apply

Box: 4 Folder: 2
1971 January 10 - 1973 February 2: Book 6 - Michael Bazaral

Restrictions Apply

Box: 4 Folder: 3
1971 February 16 - October 21: Hospital Quantitative IgE Studies and Results - C. Ashcraft

Restrictions Apply

Box: 4 Folder: 4
1971 June 17 - August 23: IgE

Restrictions Apply

Box: 4 Folder: 5
1971 September 14 - 1972 May 4: IgE Assays I - Eva Lydick

Restrictions Apply

Box: 4 Folder: 6
1972 January 20 - June 19: Book 3 - Eva Lydick

Restrictions Apply

Box: 4 Folder: 7
1972 January 20 - 1977 May 31: Immunizations and Bleedings
Box: 5 Folder: 1
1972 February - 1973 May 30: H. Alice Orgel

Restrictions Apply

Box: 5 Folder: 2
1972 March 14: Navy Babies/IgE Levels of Newborns - Michael Lenoir and H. Alice Orgel

Restrictions Apply

Box: 5 Folder: 3
1972 May 10 - 1973 January 10: IgE Assays II - Eva Lydick

Restrictions Apply

Box: 5 Folder: 4
1972 October 19 - 1973 October 30: Diphtheria Assay I

Restrictions Apply

Box: 5 Folder: 5
1972 December 1 - 1973 March 31: Laboratory Notes - Robert Hamburger

Restrictions Apply

Box: 5 Folder: 6
1973 January 17 - 1974 March 29: IgE Assays III - Eva Lydick

Restrictions Apply

Box: 5 Folder: 7
1973 June 25 - 1974 March 8: Book 7 - Eva Lydick

Restrictions Apply

Box: 6 Folder: 1
1973 October 31 - 1976 June 10: Diphtheria Assay II - Book 2

Restrictions Apply

Box: 6 Folder: 2
1974 January 18 - 1975 June 24: Mad Scientist - Harvey Gorrin

Restrictions Apply

Box: 6 Folder: 3
1974 March 13 - October 15: IgE Assays IV - Robert Hamburger

Restrictions Apply

Box: 6 Folder: 4
1974 June 4 - 1975 August 14: Mason I - Donna Mason

Restrictions Apply

Box: 6 Folder: 5
1974 July 10 - 1976 May 18: Precipitins to Milk and Precipitins to Aspergillus - Lab Book 1

Restrictions Apply

Box: 6 Folder: 6
1974 October 21 - 1975 January 7: IgE Assay V
Box: 6 Folder: 7
1974 December 19 - 1975 September 2: IgE Double Ab Assay

Restrictions Apply

Box: 7 Folder: 1
1975 January 4 - 1983 January: Immunoglobulins

Restrictions Apply

Box: 7 Folder: 2
1975 October 7 - 1976 July 17: BSB 4033 Book II - Robert Wilcsek

Restrictions Apply

Box: 7 Folder: 3
1976 June 1 - 1979 September 21: Milk Precipitins and Hypersensitivity Pneumonitis - Lab Book 2

Restrictions Apply

Box: 7 Folder: 4
1976 August 26 - 1982 July 29: Pediatric Immunology and Allergy Division - D. Mason, D. Melvin and M. Wiley

Restrictions Apply

Box: 7 Folder: 5
1976 September 29 - 1978 January 4: IgE Double Ab Assay

Restrictions Apply

Box: 7 Folder: 6
1976 November 17 - 1977 July 14: Histamine/IgE Assays

Restrictions Apply

Box: 8 Folder: 1
1977 January 24 - August 23: Lymphocyte Transformation Studies I - Sylvia Johnson

Restrictions Apply

Box: 8 Folder: 2
1977 June 20 - August 22: Lymphocyte Transformation and Rosettes Patients I - Sylvia Johnson

Restrictions Apply

Box: 8 Folder: 3
1977 June 20 - August 22: Lymphocyte Transformation and Rosettes Patients II - Sylvia Johnson

Restrictions Apply

Box: 8 Folder: 4
1978 July 19 - 1979 March 21: Basophil Degranulation Inhibition by Pentapeptide - Bob Ziering

Restrictions Apply

Box: 8 Folder: 5
1979 October 25 - 1980 April 30: Etiologic Role of Allergic Rhinitis in Serous Otitis Media - D. Cook, H. Ort

Restrictions Apply

Box: 8 Folder: 6
1980 July 28 - 1985 August 2: Lymphocyte Transformation - Book IV

Restrictions Apply

Box: 8 Folder: 7
1981 February 10 - 1982 August 10: Diphtheria Assay - Book IV

Restrictions Apply

Box: 9 Folder: 1
1981 February 12 - 1983 March 16: Pediatric Immunology and Allergy Division - Hector Heredia

Restrictions Apply

Box: 9 Folder: 2
1981 April 22 - November 23: Pediatric Immunology and Allergy Division/Kaiser study - Quants, IgA, M and G

Restrictions Apply

Box: 9 Folder: 3
1981 September 12 - December 14: Peptide Research - John Bastian

Restrictions Apply

Box: 9 Folder: 4
1981 October 13 - 1982 March 23: ISP - Diana Hu

Restrictions Apply

Box: 9 Folder: 5
1982 July 12 - 1983 February 7: Diphtheria E.I.A

Restrictions Apply

Box: 9 Folder: 6
1982 December 21 - 1984 September 10: Serum Free Media, Human Dagmara Tubelis

Restrictions Apply

Box: 9 Folder: 7
1983 March 7 - May 4: Pediatric Immunology and Allergy Division, lab data - Hector Heredia
Box: 10 Folder: 1
1983 March 11 - June 22: Peptide Studies - Maryetta Hornbeck

Restrictions Apply

Box: 10 Folder: 2
1983 November 7 - 1984 May 29: AIDS Study

Restrictions Apply

Box: 10 Folder: 3
1984 January 5 - December 22: RAST Worksheets

Restrictions Apply

Laboratory Subject Files

Box: 11 Folder: 1
1962: Tissue culture summary data
Box: 11 Folder: 2-5
1964 - 1967: Correspondence
Box: 11 Folder: 6
1967: Lab result photos, urea/glycine gel
Box: 11 Folder: 7
1968: Correspondence
Box: 11 Folder: 8
1970: IgE mother-baby study
Box: 11 Folder: 9
1970-1972: Twin study

Restrictions Apply

Box: 11 Folder: 10
1974: Correspondence
Box: 11 Folder: 11
1974: Disophrol and it's components in seasonal allergic rhinitis study
Box: 11 Folder: 12-14
1974-1978: Albuterol studies - Schering Corporation
Box: 11 Folder: 15
1974-1979: Allergy in infants study

Restrictions Apply

Box: 11 Folder: 16
1975: Correspondence - FDA
Box: 11 Folder: 17
1975: Correspondence - General laboratory
Box: 11 Folder: 18
1975: In vitro pentapeptide tests, 1-7
Box: 11 Folder: 19
1975: Peptide displacement experiment
Box: 11 Folder: 20
1975: Peptide inhibition of allergy study
Box: 11 Folder: 21
1975: Peptide stability study, electrophoresis strip photos - Peninsula Laboratories, Inc
Box: 11 Folder: 22
1975-1977: Peptide studies - Syntex Corporation
Box: 11 Folder: 23
1976: Correspondence - FDA
Box: 11 Folder: 24
1976: Correspondence - General laboratory
Box: 11 Folder: 25
1976: IgE low level assay
Box: 11 Folder: 26
1976: Notice of claimed investigational exemption for a new drug - Pentapeptide D-S-D-P-R
Box: 11 Folder: 27
1976: Statement of investigator - Pentapeptide D-S-D-P-R
Box: 12 Folder: 1
1976: Thymosin in primary cellular immunodeficiencies protocol
Box: 12 Folder: 2
1976: Vaceril studies - Schering Corporation
Box: 12 Folder: 3
1976-1983: HEPP clinical studies summary, part I
Box: 12 Folder: 4
1976-1983: HEPP clinical studies summary, part II
Box: 12 Folder: 5
1977: Correspondence - FDA
Box: 12 Folder: 6
1977: Correspondence - General laboratory
Box: 12 Folder: 7
1978: Correspondence - FDA
Box: 12 Folder: 8
1978: FDA inspection
Box: 12 Folder: 9
1978: Peptides quality control records - Peninsula Laboratories, Inc
Box: 12 Folder: 10
1978-1979: Cyclic amp/gmp notes
Box: 12 Folder: 11
1978-1979: Passive immunity notes
Box: 12 Folder: 12
1978-1980: IgE low level studies
Box: 12 Folder: 13
1978-1980: Skin tests/radio allergosorbent test (RAST) results

Restrictions Apply

Box: 12 Folder: 14
1978-1983: Human IgE pentapeptide toxicology summary
Box: 12 Folder: 15
1979: Correspondence - FDA
Box: 12 Folder: 16
1979: Correspondence - General laboratory
Box: 12 Folder: 17
1979: HEPP inhibition of allergy study - APCo, Inc
Box: 12 Folder: 18
1979: IgE PRIST studies
Box: 12 Folder: 19
1979: Lab notes
Box: 12 Folder: 20
1979: Notice of claimed investigational exemption for a new drug - Pentapeptide D-S-D-P-R
Box: 12 Folder: 21
1979-1980: HEPP studies

Restrictions Apply

Box: 12 Folder: 22
1979-1984: HEPP clinical study summaries
Box: 12 Folder: 23
1980: Amino acid electrophoresis data
Box: 13 Folder: 1
1980: Correspondence - FDA
Box: 13 Folder: 2
1980: Correspondence - General laboratory
Box: 13 Folder: 3
1980: FDA inspection
Box: 13 Folder: 4
1980: Guidelines for the evaluation of endogenous peptides and their analogs
Box: 13 Folder: 5
1980: IgE/radio allergosorbent test (RAST) - Kaiser study

Restrictions Apply

Box: 13 Folder: 6
1980: Kallstad comparison data
Box: 13 Folder: 7
1980: Milestones document
Box: 13 Folder: 8
1980-1981: Enzyme immunoassay for immunoglobulin E study - CalBiochem
Box: 13 Folder: 9
1980-1981: Immunoradiometric assay for IgE - Hybritech, Inc
Box: 13 Folder: 10
1981: Correspondence - FDA
Box: 13 Folder: 11
1981: Correspondence - General laboratory
Box: 13 Folder: 12
1981: IgE research results - Hybritech, Inc

Restrictions Apply

Box: 13 Folder: 13
1981: Peptide nomenclature
Box: 13 Folder: 14
1981: Research results

Restrictions Apply

Box: 13 Folder: 15
1981-1982: Efficacy and safety comparison study of choledyl and theodur tablets - Warner Lambert/Parke Davis
Box: 13 Folder: 16
1981-1982: HEPP research results - UCLA Statistical/Biomathematical Consulting Center

Restrictions Apply

Box: 13 Folder: 17-18
1981-1983: HEPP therapeutic trial (25-day, 38 patient) double-blind, randomly selected, placebo-controlled
Box: 13 Folder: 19
1981-1983: Intranasal toxicity test in rabbits via nasal spray - Immunetech, Inc
Box: 13 Folder: 20
1982: Amino acid electrophoresis data
Box: 13 Folder: 21
1982: Correspondence - FDA
Box: 14 Folder: 1
1982: Correspondence - FDA
Box: 14 Folder: 2
1982: Correspondence - General laboratory
Box: 14 Folder: 3
1982: Efficacy of HEPP protein in the treatment of allergy
Box: 14 Folder: 4
1982: FDA inspection
Box: 14 Folder: 5
1982: HEPP acute intravenous toxicity study in mice
Box: 14 Folder: 6-7
1982: HEPP trial (14-day, 12 patient) double-blind, dose response, placebo-controlled

Restrictions Apply

Box: 14 Folder: 8-11
1982-1984: HEPP phase II, double-blind, randomized, placebo-controlled
Box: 14 Folder: 12
1982-1984: IgA and IgE research data
Box: 14 Folder: 13
1983: Clr = ClEs function
Box: 14 Folder: 14
1983: Correspondence - FDA
Box: 14 Folder: 15
1983: Correspondence - General laboratory
Box: 15 Folder: 1
1983: Diphtheria-tetanus test results

Restrictions Apply

Box: 15 Folder: 2
1983: HEPP subacute subcutaneous toxicity study in rats
Box: 15 Folder: 3
1983: IgE egg research data
Box: 15 Folder: 4
1983: SAI inspection of toxicological testing facility
Box: 15 Folder: 5
1983-1984: HEPP intranasal administration, double-blind study
Box: 15 Folder: 6-7
1983-1984: HEPP phase II study results and phase III clinical protocol - Immunetech, Inc
Box: 15 Folder: 8-9
1983-1984: HEPP phase III, subcutaneous, double-blind, randomized, placebo-controlled
Box: 15 Folder: 10-11
1983-1986: HEPP three-year plan, volumes I & II
Box: 16 Folder: 1
1984: Correspondence - FDA
Box: 16 Folder: 2
1984: Correspondence - General laboratory
Box: 16 Folder: 3
1984: HEPP metabolism studies
Box: 16 Folder: 4
1984: HEPP rabbit teratology - Science Applications, Inc
Box: 16 Folder: 5
1984: HEPP rat subchronic toxicology - Science Applications, Inc
Box: 16 Folder: 6
1984: HEPP safety and efficacy in patients with perennial allergic rhinitis
Box: 16 Folder: 7
1984: HEPP USAN listing request
Box: 16 Folder: 8
1984: Milk-specific IgA E.I.A
Box: 16 Folder: 9
1984: Notice of claimed investigational exemption for a new drug - Pentapeptide D-S-D-P-R, Immunetech, Inc
Box: 16 Folder: 10
1984-1986: HEPP ophthalmic clinical study - Immunetech, Inc
Box: 16 Folder: 11
1985: Correspondence - General laboratory
Box: 16 Folder: 12
1985: Diphtheria-tetanus test results

Restrictions Apply

Box: 16 Folder: 13
1985: HEPP double-blind study of the effect of 3 weeks of treatment on the nasal provocation test - Merck
Box: 16 Folder: 14
1985: HEPP ophthalmic solution

Includes notice of claimed investigational exemption, animal toxicology results and ophthalmic solution clinical protocol - Immunetech, Inc.

Box: 16 Folder: 15
1985: HEPP ophthalmic solution phase II clinical results - Immunetech, Inc
Box: 16 Folder: 16
1985: HEPP summary of data on the efficacy and tolerance
Box: 16 Folder: 17
1985: Statement of investigator - Pentapeptide D-S-D-P-R
Box: 16 Folder: 18
1986: Clinical advantages of HEPP over conventional antiallergy drugs - Draft report
Box: 16 Folder: 19
1986: Correspondence - General laboratory
Box: 16 Folder: 20
1986: Diphtheria-tetanus test results

Restrictions Apply

Box: 16 Folder: 21
1986: HEPP bioavailability study
Box: 16 Folder: 22
1986: HEPP for injection study
Box: 16 Folder: 23
1986: HEPP intranasal phase III study
Box: 16 Folder: 24
1986: HEPP ophthalmic solution dose range clinical trial summary
Box: 16 Folder: 25
1986: HEPP ophthalmic solution test results

Restrictions Apply

Box: 17 Folder: 1
1989: Nasal NDA summary, clinical section - Immunetech, Inc
Box: 17 Folder: 2
1989: Pentyde nasal solution three week safety and efficacy study - Immunetech, Inc
Box: 17 Folder: 3
Undated: Mitogen stim. indexes

Restrictions Apply

Box: 17 Folder: 4
Undated: Unidentified laboratory notes

Patent Files

Box: 17 Folder: 5
1963: Agreement with the University of California
Box: 17 Folder: 6
1974-1975: Correspondence
Box: 17 Folder: 7
1976: Correspondence
Box: 17 Folder: 8
1976: Polypeptide Agents for Blocking the Human Allergic Response - Patent
Box: 17 Folder: 9
1977: Application amendment
Box: 17 Folder: 10-12
1977-1979: Correspondence
Box: 17 Folder: 13
1979: Method for Blocking Allergic Response - Patent
Box: 17 Folder: 14
1979: Option agreement

Agreement for APCo's commercial development of Robert Hamburger's UC-owned patent entitled: Polypeptide Agents for Blocking the Human Allergic Response.

Box: 17 Folder: 15
1980-1981: Correspondence
Box: 17 Folder: 16
1982: Agreement with the University of California
Box: 17 Folder: 17
1982: Correspondence
Box: 17 Folder: 18
1983-1986: Correspondence

Grant Files

Box: 17 Folder: 19
1962-1967: Genetics course - National Institutes of Health
Box: 17 Folder: 20
1964: Research grant - National Institutes of Health
Box: 17 Folder: 21
1964-1971: Immune Kill and Cells in Tissue Culture - National Institutes of Health
Box: 18 Folder: 1
1964-1971: Immune Kill and Cells in Tissue Culture - National Institutes of Health
Box: 18 Folder: 2
1965: Research grant - University of California, San Diego
Box: 18 Folder: 3
1969: Antigenic Enhancement by Foreign Haptens - American Cancer Society (not funded)
Box: 18 Folder: 4
1971: Genetics of Immunoglobulin E - National Institutes of Health
Box: 18 Folder: 5
1976-1977: Development and Genetics of IgE and Allergy - National Institutes of Health
Box: 18 Folder: 6
1977: Atopy and IgE Synthesis - National Institutes of Health
Box: 18 Folder: 7
1977: Safety and Toxicity of Synthetic IgE - University of California, San Diego
Box: 18 Folder: 8
1979: Biomedical Research Support Grant - National Institutes of Health
Box: 18 Folder: 9
Undated: Development of Immunoglobulin E - National Institutes of Health

WRITINGS BY ROBERT HAMBURGER

Abstracts and Reprints

Box: 18 Folder: 10
Robert Hamburger's bibliography, 1950 - 1978
Box: 18 Folder: 11
All About Allergy Shots - Abstract, 1976
Box: 18 Folder: 12
Allergy and the Immune System - Reprint, 1976
Box: 18 Folder: 13
Anaphylaxis-like Reactions to Corticosteroid Therapy - Photocopy of original article, 1974
Box: 18 Folder: 14
Antigenic Determinants on the Chloramphenicol Molecule - Abstract, undated
Box: 18 Folder: 15
Antigenic Specifications Acquired From the Growth Medium by Cells in Tissue Culture - Reprint, 1963
Box: 18 Folder: 16
Atmospheric Pollen and Spore Sampling in San Diego, California - Reprint, 1976
Box: 18 Folder: 17-18
Chloramphenicol-Specific Antibody - Abstract & reprint, 1966
Box: 18 Folder: 19
Clonal Growth of Primary Human Cell Cultures - Reprint, 1964
Box: 18 Folder: 20
Conservation of Active Sites in Molecules with Immunoglobulin Fold Domain Structure - Reprint. (Chapter 16 of Immunologic Analysis), undated
Box: 18 Folder: 21
Current Status of the Clinical and Immunologic Consequences of a Prototype Allergic Disease Prevention Program - Typescript, 1983
Box: 18 Folder: 22
Development and Inheritance of IgE and Allergy - Reprint, 1974
Box: 18 Folder: 23
Development and Inheritance of IgE Mediated Hypersensitivity - Typescript, 1978
Box: 18 Folder: 24
Development of Atopic Allergy in Children - Reprint, 1980
Box: 18 Folder: 25
Development of Gamma Globulins in the Human Newborn - Abstract, 1968
Box: 18 Folder: 26-27
Development of IgE and Allergy in Infancy - Typescript & reprint, 1974
Box: 18 Folder: 28
Diagnosis and Prophylaxis of Atopic Allergic Diseases in the First Three Years of Life - Reprint, 1979
Box: 18 Folder: 29
Evolutionary Relationship of Thymopoietin to Immunoglobulins and Cellular Recognition Molecules - Reprint, 1981
Box: 18 Folder: 30
Genetics of IgE and Allergy: Serum IgE Levels in Twins - Reprint, 1974
Box: 18 Folder: 31
IgE and Allergy - Reprint, 1976
Box: 18 Folder: 32
IgE Levels in Normal Infants and Mothers and an Inheritance Hypothesis - Reprint, 1971
Box: 18 Folder: 33
Immunoglobulin E in Leprosy - Abstract, undated
Box: 18 Folder: 34
Induction of the Lupus Erythematosus ("L.E.") Cell In Vitro in Peripheral Blood - Reprint, 1950
Box: 18 Folder: 35
Inhibition by IgE Pentapeptide of IgE Rosette Formation by Human Basophils - Abstract, 1982
Box: 18 Folder: 36
Inhibition of IgE Binding to Tissue Culture Cells and Leucocytes by Pentapeptide - Photocopy of original article, 1979
Box: 18 Folder: 37
Metabolism of IgE in Transfused Infants - Abstract, 1974
Box: 18 Folder: 38
New Experimental Approaches to the Therapy of Atopic Diseases - Galley proof & reprint, 1983
Box: 18 Folder: 40
New Means for Serum IgE Levels Result from Changes in Measurement Methodology - Abstract, 1979
Box: 18 Folder: 41
Newer Bronchodilators - Abstract, undated
Box: 18 Folder: 42
Niveles de Immunoglobulina E, Herencia a la Alergia e Inmunidad a las Helmintos - Photocopy of original article, 1973
Box: 18 Folder: 43
Of Many Things... And the Immune System - Reprint, 1978
Box: 18 Folder: 44
Office Diagnosis of Immunodeficiency Disease - Typescript, undated
Box: 18 Folder: 45-46
Passive Immune Kill and Pseudo-Autoimmune Disease: Proposed Model for Chloramphenicol Induced Aplastic Anemia - Correspondence, 1967-1968
Box: 18 Folder: 47-49
Passive Immune Kill of Cells in Tissue Culture - Correspondence, reprint & typescript, 1965
Pediatric Immunology and Allergy
Box: 18 Folder: 50
Chapter 1: Introduction - Draft, undated
Box: 18 Folder: 51
Chapter 2: Human Fetal Immune System - Draft, undated
Box: 18 Folder: 52
Chapter 3: Development of Antigen Responses in the Fetus - Draft, undated
Box: 19 Folder: 1
Chapter 3: Reference articles
Box: 19 Folder: 2
Chapter 5: Development in the First Year of Life - Draft, undated
Box: 19 Folder: 3
Chapter 5: Reference articles
Box: 19 Folder: 4
Chapter 6: Strategy of Immunizations - Draft, undated
Box: 19 Folder: 5
Chapter 6: Reference articles
Box: 19 Folder: 6
Chapter 7: Some Genetics of the Immune System - Draft, undated
Box: 19 Folder: 7
Chapter 7: Reference articles
Box: 19 Folder: 8
Chapter 8: Draft, undated
Box: 19 Folder: 9
Chapter 8: Reference articles
Box: 19 Folder: 10
Chapter 9: Pages 7-9 only - Draft, undated
Box: 19 Folder: 11
Chapter 10: Laboratory Techniques - Draft, undated
Box: 19 Folder: 12
Correspondence, 1979
Box: 19 Folder: 13
Peptide Inhibition of the Prausnitz-Kustner Reaction - Reprint, 1975
Box: 19 Folder: 14
Prophylaxis of Allergy - Abstract, 1976
Box: 19 Folder: 15
Prophylaxis of Allergy in Infants Debate - Abstract, undated
Box: 19 Folder: 16-17
Radio Allergosorbent Test (RAST) and Skin Tests in Low IgE Individuals - Abstract & research notes for writing, 1979 - 1980 & undated
Box: 19 Folder: 18
Recent Studies with Human IgE Pentapeptide (HEPP) - Reprint, 1981
Box: 19 Folder: 19
Regulation and Measurement of IgE in Atopy - Typescript, undated
Box: 19 Folder: 20-22
Results of a Double-Blind Randomly Selected Placebo-Controlled Therapeutic Trial of Human IgE Pentapeptide - Abstract, undated
Box: 19 Folder: 23
Safety and Efficacy of Human IgE Pentapeptide - Abstract, 1984
Box: 19 Folder: 24
Separation of Electophoretic Bands from a Bence-Jones Protein - Abstract, 1968
Box: 19 Folder: 25
Some New Studies With Human IgE Pentapeptide (HEPP) - Abstract, undated
Box: 19 Folder: 26
Standardization and Stability of Immunoglobulin E (IgE) - Reprint, 1972
Box: 19 Folder: 27
Statement from UCSD to the California Senate Fact Finding Committee of Public Health and Safety - Typescript, 1966
Box: 19 Folder: 28
Studies of Human IgE Pentapeptide: HEPP - Reprint, 1980
Box: 19 Folder: 29-30
Transfused Immunoglobulin E in Newborns, Letter to the Editor - Photocopy of original article & typescript, 1982
Box: 19 Folder: 31
Unidentifiable notes, figures and tables used in miscellaneous writings, undated
Box: 19 Folder: 32
Untitled, undated writing
Box: 19 Folder: 33
Use of the Laboratory in the Diagnosis of Allergic Disease - Photocopy of original article, 1986
Box: 19 Folder: 34
Value of PRIST, RAST and Skin Tests in Selected Individuals - Abstract, undated

Talks and Lectures

Box: 19 Folder: 35
List of talks and lectures by Robert Hamburger, 1965 - 1968
Box: 19 Folder: 36
Allergic Tissue Damage and Foreign Anitgens - Typescript, 1969

Presented at the 4th Nuffield Conference on Rheuatism, Oxfordshire, England.

Box: 19 Folder: 37
Allergy, Immunology and the Inheritance of IgE Levels - Typescript, 1971

Presented at a West Coast Allergy Society meeting.

Box: 19 Folder: 38
Allergy, Pathology Lecture - Handwritten introduction and list of slides for lecture, 1982
Box: 19 Folder: 39
Allergy Physician's Assistant (APA) Training Program - Abstract, 1975

Presented at an American Academy of Allergy meeting.

Box: 19 Folder: 40
Allergy Testing for the Primary Care Physician - Typescript outline, 1982

Presented at the 26th Annual Symposium of the San Diego Academy of Family Physicians.

Box: 19 Folder: 41
Atopic Asthma - List of slides, 1980

Presented at a meeting in Medellin, Columbia.

Box: 19 Folder: 42
Atopy, Hypersensitivity or Allergy - Handwritten draft, 1976

Presented to Core Medical Education students.

Biologic Basis For a New Therapeutic Approach to Allergic Disease
Box: 19 Folder: 43
Abstract, 1975

Presented at an American Academy of Allergy meeting and the Second Charles Blackley Symposium.

Box: 19 Folder: 44
List of slides, undated

Presented at the Second Charles Blackley Symposium.

Box: 19 Folder: 45
Biology of IgE - List of slides, 1977

Presented at Pomona College, California.

Box: 19 Folder: 46
Blockade of Mast Cell Receptors for the Treatment of Human Allergies - Handwritten draft, 1976

Presented at a Canadian Society of Allergy and Clinical Immunology meeting.

Box: 19 Folder: 47
Clinical Manifestations of Atopy - List of slides, 1977

Presented to a Pathology class.

Box: 19 Folder: 48
Development and Genetics of IgE and Allergy - Typescript, 1976

Presented at a joint meeting of the Northern California Section of the American Association of Clinical Chemists and the California Association of Bioanalysts.

Box: 19 Folder: 49
Development and Inheritance of IgE Mediated Hypersensitivity - List of slides, 1978

Presented at USC's Practical Allergy and Immunology Conference.

Box: 19 Folder: 50
Development of IgE and Allergy - Handwritten outline, 1975

Presented to biology students at Mar Vista High School, San Diego.

Development of IgE and Allergy During the First Year of Life: Preliminary Data
Box: 19 Folder: 51
Abstract, 1974

Presented at the 30th Annual American Academy of Allergy Meeting.

Box: 19 Folder: 52
Correspondence, 1973 - 1974
Box: 19 Folder: 53
Research notes for lecture, 1974
Box: 19 Folder: 54
Development of IgE in Infancy and Childhood - Handwritten draft, 1975

Presented at a West Coast Allergy Society meeting.

Box: 19 Folder: 55
Development of the IgE Allergy System and it's Effect on Subsequent Atopic Allergy - Typescript and slide list

Undated.

Box: 19 Folder: 56
Developmental Immunology and Allergy in the First Two Years of Life - Handwritten draft, 1975

Presented at a March of Dimes sponsored event at Sunrise Hospital, Las Vegas, Nevada.

Box: 19 Folder: 57
Diagnostic Update in Allergy - Handwritten outline and list of slides, 1977

Presented at Paradise Valley Hospital, San Diego for the Core Medical Education Program.

Box: 19 Folder: 58
Diagnostic Value and Problems of Skin Tests, PRIST and RAST and Food Allergy - Tables used in lecture, 1980

Presented at a meeting in Monterrey, Mexico.

Box: 19 Folder: 59
Dose Response to Human IgE Pentapeptide (HEPP) - Abstract, 1983

Presented at the 39th Annual Congress of the American College of Allergists, New Orleans, Louisiana.

Box: 20 Folder: 1
Effect of Oral Albuterol on Plasma Cyclic Adenosine Monophosphate - Abstract, 1975

Presented at an American Academy of Allergy meeting.

Box: 20 Folder: 2
Experience with Carnation Hypoallergenic Formula - Typescript, 1988

Presented at the Food Allergy Symposium, New York.

Box: 20 Folder: 3
Genetics and Allergy - Typescript, 1982

Presented at the Southwest Allergy Symposium.

Box: 20 Folder: 4
IgE and Allergy - List of slides, 1974

Presented at the U.S. Naval Hospital, Pediatrics Department, San Diego.

Box: 20 Folder: 5
IgE and HEPP on the Wil-2 WT Cell (lecture 1) and Mechanism and Inheritance of Allergy (lecture 2), 1978

Contains list of slides for both lectures. Presented at a meeting in Birmingham and to Core Medical Education students.

Box: 20 Folder: 6
IgE, Biology and Clinical Activity - List of slides, 1974

Presented at the U.S. Naval Hospital, Dermatology Department, San Diego.

Box: 20 Folder: 7
IgE Blocking Peptide - Handwritten draft, 1975

Presented at the San Diego Pulmonary Society Conference.

Box: 20 Folder: 8
IgE in Allergy - Handwritten draft and list of slides, 1973
Box: 20 Folder: 9
IgE in Food Allergy - Typescript and photocopies of slides, undated
Box: 20 Folder: 10
IgE, Peptides and Allergy - Handwritten draft, 1975

Presented at Grand Rounds, University Hospital, San Diego.

Box: 20 Folder: 11
Immune Response to Chloramphenicol - Typescripts in English and Spanish, undated
Box: 20 Folder: 12
Immunization - Handwritten outline, 1966

Presented at a Peace Corp meeting.

Box: 20 Folder: 13
Immunodeficiency and Allergic States - Handwritten outline, 1980

Presented at a meeting in Acapulco.

Box: 20 Folder: 14
Immunologic Deficiency Disease - Handwritten outline and list of slides, 1975

Presented at Doctor's Hospital, San Diego.

Box: 20 Folder: 15
Immunology of Breast Milk and Phophylaxis of Allergy - Handwritten draft, 1979

Presented at the Pediatric Grand Rounds, University Hospital, San Diego.

Box: 20 Folder: 16
Immunotherapy - List of slides, undated
Box: 20 Folder: 17
Improved Screening Method for Anti-Chloramphenicol Antibodies - Abstract, 1970

Presented at the 17th Annual Western Society for Pediatric Research meeting, Carmel, California.

Box: 20 Folder: 18
Indications for Hyposensitization, Desensitization, Injection Therapy, and Immunotherapy - Handwritten outline, 1974

Presented at the U.S. Naval Hospital, Pediatrics Department, San Diego.

Box: 20 Folder: 19
International Meeting of Asthmology lecture - Typescript in English and Spanish, 1974

Presented at the Interasma Conference, Havana, Cuba.

Box: 20 Folder: 20
Is it Immune Deficiency or Just a Bad Winter? Typescript outline, 1982
Box: 20 Folder: 21
Joseph Weiner, M.D. Memorial Lecture - Handwritten draft introduction, 1983

Presented at St. Raphael Hospital, Milford, Connecticut.

Box: 20 Folder: 22
Journal Club Lecture - Handwritten draft introduction, 1966

Presented at Children's Hospital of Orange County, California.

Box: 20 Folder: 23
Los Angeles Allergy Society Lecture - Handwritten draft introductions, 1 - 3, 1975
Box: 20 Folder: 24
Management of Asthma - Handwritten draft, 1978

Presented as an American Academy of Pediatrics Core Medical Education Course, University Hospital, San Diego.

Box: 20 Folder: 25
More About IgE Than You'd Care to Know - Handwritten draft and list of slides, 1975
Box: 20 Folder: 26
Once Around [the World] - Handwritten draft, 1978
Box: 20 Folder: 27
Paramedical Aspects of Medical Treatment of Chest Diseases - Typescript, 1978

Presented at the Interasthma Congress.

Box: 20 Folder: 28
Pediatric Allergy - List of slides, 1980
Box: 20 Folder: 29
Peptide Inhibition of Allergic Reaction - List of slides, 1976
Box: 20 Folder: 30
Prediction, Prevention and Treatment of Allergic Asthma - Handwritten draft, 1976

Presented at John D. Spreckles Lodge, San Diego. Sponsored by the Lung Association of San Diego and Imperial Counties.

Box: 20 Folder: 31
Preparation for General Pediatrics and Sub-Specialty Training - Typescript, undated

Presented at the Congresos De Pediatria, Mexico.

Box: 20 Folder: 32
Present and Future in Treatment of Allergic Diseases - List of slides, 1980

Presented at a meeting in Medellin, Colombia.

Box: 20 Folder: 33
Prophylaxis of Allergy in Infants Debate - Handwritten outline and list of slides, 1976

Presented at an immunology conference.

Box: 20 Folder: 34
Prophylaxis of Atopic Asthma in the First Two Years of Life - Typescript, 1978

Presented at the IX Interasthma Congress, New Orleans, Louisiana.

Pseudo-Autoimmune Disease
Box: 20 Folder: 35
Correspondence, 1965 - 1966
Box: 20 Folder: 36
Typescript, 1965

Presented at the XI International Congress of Pediatrics, Tokyo, Japan.

Box: 20 Folder: 37
Radio Allergosorbent Test (RAST) - List of slides, 1981

Presented at the Second Annual Course on Selected Topics in Immunology, School of Medicine, University of Guadalajara.

Box: 20 Folder: 38
Serum Assays for Antigen Specific IgE Antibody - Handwritten introduction and list of slides, 1981

Presented at an American College of Allergists meeting.

Box: 20 Folder: 39
Sickle Cell Anemia - Handwritten outline, 1969

Presented at a Charles Drew Foundation meeting.

Box: 20 Folder: 40
T-Cell Modulation of IgE Production - Handwritten introduction and list of slides, 1980

Presented at a West Coast Allergy Society meeting, Acapulco.

Box: 20 Folder: 41
Treatments of the Future - Handwritten introduction and list of slides, 1977

Presented at the VII Congreso Medico Estatal, Tijuana, Mexico.

Box: 20 Folder: 42
UCSD Allergy in Infancy Study: An Interim Report - Typescript and list of slides, 1978

Presented at a West Coast Allergy Society meeting.

Box: 20 Folder: 43
Understanding Allergy - Handwritten draft, 1976

Presented at the UCSD Medical Center Auxiliary Health Education Lecture Series.

Box: 20 Folder: 44
Values and Problems with PRIST and RAST in Children - Abstract, 1979

Presented at the American Academy of Pediatrics Annual Meeting.

Box: 20 Folder: 45
What Can Our Friends the Animals Tell Us About IgE Mediated Disease in Humans? Handwritten draft, 1975

Presented at a Journal Club meeting.

Box: 20 Folder: 46
Where Are We and Where Are We Going in Allergy? Handwritten note cards, undated
Box: 20 Folder: 47-48
Untitled lectures - Handwritten drafts and typescripts, 1973 - 1981

Book Reviews for Journals

Box: 20 Folder: 49
Annals of Allergy, 1977 - 1985
Box: 20 Folder: 50
Journal of Allergy and Clinical Immunology, 1979 - 1985
Box: 20 Folder: 51
Journal of Laboratory and Clinical Medicine, 1977
Box: 20 Folder: 52
Science, 1973

WRITINGS OF OTHERS

Box: 20 Folder: 53
List of writings of others kept on Robert Hamburger's desk, undated
Box: 20 Folder: 54-55
Annotated by Robert Hamburger, A - H
Box: 21 Folder: 1-2
Annotated by Robert Hamburger, I - V
Box: 21 Folder: 3
Unidentified authors

BIOTECHNOLOGY DEVELOPMENT FIRMS

APCo, Inc. (Allergy Peptide Company, Inc.)

Box: 21 Folder: 4
Business documents, 1978 - 1982
Box: 21 Folder: 5
Correspondence, 1981 - 1982
Box: 21 Folder: 6
Deed of gift to the UC Regents, 1982
Box: 21 Folder: 7
Income tax returns, 1981 - 1982
Box: 21 Folder: 8
Joint venture proposal from Immunoscience Corp., 1979
Box: 21 Folder: 9
Option agreement, 1979

Cytotech, Inc.

Box: 21 Folder: 10
Amended and Restated Articles of Incorporation, 1987
Box: 21 Folder: 11
Brochure, 1983
Box: 21 Folder: 12
Correspondence, 1982 - 1988
Box: 21 Folder: 13
Human complement product list, 1985
Box: 21 Folder: 14
News clippings of Cytotech, Inc., 1984 - 1985
Box: 21 Folder: 15
News clippings of other companies, 1981
Box: 21 Folder: 16-17
Private Placement Memorandum, 1982 - 1984
Box: 22 Folder: 1
Product proposals, undated
Box: 22 Folder: 2-4
Report and financial statements, 1983 - 1988
Box: 22 Folder: 5
Resolution Amending Articles of Incorporation as to Series B Convertible Preferred Stock, undated
Box: 22 Folder: 6
Series B Convertible Preferred Stock Purchase Agreement, 1984
Box: 22 Folder: 7
Series B Convertible Preferred Stock Registration Rights Agreement, 1984
Box: 22 Folder: 8
Shareholder Consent Form, 1989
Box: 22 Folder: 9
Unidentified report, undated

McKewon and Timmons Investment Bankers

Box: 22 Folder: 10
Correspondence, 1983 - 1987
Box: 22 Folder: 11
News clippings, 1984
Box: 22 Folder: 12
Private Placement Memorandum, 1983
Box: 22 Folder: 13
Quarterly reports, 1984 - 1986

Immunetech, Inc.

Box: 22 Folder: 14
Agreement for Purchase and Sale of Assets between Robert Hamburger, APCo, Inc. and Immunetech, Inc., 1981
Box: 22 Folder: 15
Agreements between Herbert S. Lightstone and Immunetech, Inc., 1982 - 1984
Box: 22 Folder: 16
Balance sheet, 1984
Box: 22 Folder: 17
Brochures, undated
Box: 22 Folder: 18
Business plan, 1983
Box: 22 Folder: 19
Business plan summary, 1989 - 1992
Box: 22 Folder: 20
Certificate of Amendment of Articles of Incorporation, 1982
Box: 22 Folder: 21
Company logo photograph, 1981
Box: 22 Folder: 22
Confidential Disclosure Agreement, undated
Box: 22 Folder: 23-25
Corporate overview, 1982 - 1983
Correspondence
Box: 23 Folder: 1
Accounts payable, 1988
Box: 23 Folder: 2
Administrative office, 1986 - 1988
Box: 23 Folder: 3
Bausch and Lomb, Inc., 1985
Box: 23 Folder: 4
Blair, James, 1985
Box: 23 Folder: 5
Brucker, Donald, 1982 - 1985
Box: 23 Folder: 6
Down, Lisa and Norman, 1983
Box: 23 Folder: 7
Dura Pharmaceuticals, 1990
Box: 23 Folder: 8
Hahn, Gary S, 1981 - 1985
Box: 23 Folder: 9
Himel, G, 1982
Box: 23 Folder: 10
Kornberg Associates, 1983
Box: 23 Folder: 11
Lightstone, Herbert S, 1983 - 1986
Box: 23 Folder: 12
Lyon and Lyon Law Offices, 1983
Box: 23 Folder: 13
McKewon, Ray, 1981 - 1986
Box: 23 Folder: 14
Merck, E., undated
Box: 23 Folder: 15
Nelson, Norman, 1982
Box: 23 Folder: 16
O'Connor, Richard, 1982
Box: 23 Folder: 17
Pallai, Peter, 1981
Box: 23 Folder: 18
Phillips and Phillips, Attorneys at Law, 1981 - 1982
Box: 23 Folder: 19
Plummer, James, 1985
Box: 23 Folder: 20
Ramseier, Gordon, 1988
Box: 23 Folder: 21-22
Rangus, Kathryn, 1983 - 1987
Box: 23 Folder: 23
Richieri, Steven P, 1989
Box: 23 Folder: 24
Schmidt, Todd W, 1986 - 1989
Box: 23 Folder: 25
Shareholder materials, 1984 - 1991
Box: 23 Folder: 26
UCSD Office of Contract and Grant Administration, 1982
Box: 23 Folder: 27
Yakatan, Gerald J, 1989
Box: 23 Folder: 28
Development and License Agreement between Bausch and Lomb, Inc. and Immunetech, Inc., 1985
Box: 23 Folder: 29
Employment agreement, undated
Box: 23 Folder: 30
Expenses and financing, 1981 - 1986
Box: 24 Folder: 1-2
Financial statements, 1981 - 1986
Box: 24 Folder: 3
Human Complement System Proposal, 1982
Box: 24 Folder: 4
Investigator brochure, 1988
Box: 24 Folder: 5
Loan and Equity Investment Agreement, 1986
Box: 24 Folder: 6
Meetings 1981: Board of Directors (first) meeting - Minutes
Box: 24 Folder: 7
Meetings 1981: Research meeting - Agenda
Box: 24 Folder: 8
Meetings 1982: Building planning meeting - Minutes
Box: 24 Folder: 9
Meetings 1982: Meeting agendas
Box: 24 Folder: 10-12
Meetings 1983-1985: Board of Directors meetings - Agendas and minutes
Box: 24 Folder: 13
Meetings 1985: FDA meeting - Agenda and minutes
Box: 24 Folder: 14
Meetings 1985: Research presentation schedules
Box: 24 Folder: 15
Meetings 1985: Scientific Advisory Board meetings - Agendas and minutes
Box: 24 Folder: 16
Meetings 1986: Board of Directors meetings - Agendas and minutes
Box: 24 Folder: 17
Meetings 1986: Scientific Advisory meetings - Agendas
Box: 24 Folder: 18
Meetings 1987: Scientific Advisory meeting - Agenda
Box: 24 Folder: 19
Meetings 1987-1990: Shareholder meetings - Announcements
Box: 24 Folder: 20
News clippings, 1976 - 1990
Box: 24 Folder: 21
Notes on business and research, 1982 - 1986
Box: 24 Folder: 22
Private Placement Memorandum, 1984
Box: 25 Folder: 1-2
Private Placement Memorandum, 1985 - 1986
Box: 25 Folder: 3
Product Agreement with Merck, 1986
Box: 25 Folder: 4
Promissary Notes, 1985
Box: 25 Folder: 5
Proposal for the Acquisition of ABC Pharmaceuticals by Immunetech Pharmaceuticals, 1989
Box: 25 Folder: 6
Proposal to Endow a Chair in the Pediatric Immunology and Allergy Division, UCSD School of Medicine, 1982
Box: 25 Folder: 7
Report and financial statements, 1982 - 1983
Box: 25 Folder: 8
Restated Articles of Incorporation, 1986 - 1989
Box: 25 Folder: 9
Retainer Agreement with Enterprise Management Company, 1981
Box: 25 Folder: 10
Securities and Exchange Commission Registration Statement, 1984
Box: 25 Folder: 11
Securities Purchase Agreement, 1986
Box: 25 Folder: 12-13
Stockholder documents, 1981 - 1991
Box: 25 Folder: 13
Stockholder documents, 1986 - 1991
Box: 25 Folder: 14
Technology Sharing Agreement between Immunetech, Inc. and Cytotech, Inc., 1982
Box: 25 Folder: 15
Unanimous Written Consent of Directors, 1986
Box: 25 Folder: 16
Weingart Protein Sequencer Laboratory results, 1983

Immunetech Research Partners

Box: 25 Folder: 17
Agreement between Immunetech Research Partners and the Enterprise Management Company, 1981
Box: 25 Folder: 18
Comprehensive Option Agreement between Immunetech Research Partners and Immunetech, Inc., 1981
Box: 25 Folder: 19
Discussion of Management's Proposal for Immunetech Research Partners "Roll Up", 1983
Box: 25 Folder: 20
Escrow Instructions, 1981
Box: 25 Folder: 21
Fictitious Business Name Statement, 1981
Box: 25 Folder: 22
License Agreement, draft, 1981
Box: 25 Folder: 23
Partnership Agreements between R. Hamburger, R. O'Connor and G. Hahn to form Immunetech Research Partners, 1980 - 1981
Box: 26 Folder: 1
Private Placement Memorandum, June 1981
Box: 26 Folder: 2
Private Placement Memorandum, July 1981
Box: 26 Folder: 3
Proposed Concept for a New Business, 1980 - 1981
Box: 26 Folder: 4
Quarterly Progress Reports, 1982
Box: 26 Folder: 5
Research and Development Agreement between Immunetech Research Partners and Immunetech, Inc., 1981
Box: 26 Folder: 6
Retainer Agreement, 1981
Box: 26 Folder: 7
Special Report, 1982
Box: 26 Folder: 8
Technology License Agreement between Immunetech Research Partners and Immunetech, Inc., 1981

Syntex Corporation

Box: 26 Folder: 9
Consulting Agreement between Syntex and Robert Hamburger, 1976
Box: 26 Folder: 10
License Agreement between Syntex and University of California Regents, 1976
Box: 26 Folder: 11
Press release, 1976

PROFESSIONAL ORGANIZATIONS

American Academy of Allergy
Box: 26 Folder: 12
Correspondence, 1976 - 1980
Box: 26 Folder: 13
In Vitro Tests Committee, research data, meeting agendas and minutes, 1976
Box: 26 Folder: 14
American Academy of Allergy and Immunology - Correspondence, rosters and meeting minutes, 1980 - 1990
Box: 26 Folder: 15
American Academy of Pediatrics - Correspondence, 1978 - 1980
Box: 26 Folder: 16
American Association for Clinical Immunology and Allergy - Correspondence, 1978 - 1981
Box: 26 Folder: 17
American College of Allergists - Correspondence, 1980 - 1986
Box: 26 Folder: 18
American College of Allergy and Immunology - Correspondence and committee list, 1988 - 1990
Box: 26 Folder: 19
American Pediatric Society - Correspondence, 1972 - 1982
Box: 26 Folder: 20
California Committee on Therapeutic Abortion - Correspondence, 1966 - 1969
Box: 26 Folder: 21
California Medical Association - Correspondence, 1982 - 1983
Box: 26 Folder: 22
California Society of Allergy and Clinical Immunology - Correspondence, 1972 - 1990
Box: 26 Folder: 23
Children's Hospital Education Committee - Correspondence, 1968
Box: 26 Folder: 24
Clinica de Salubridad de Campesinos - Correspondence, 1974 - 1981
Box: 26 Folder: 25