Robert N. Hamburger Papers, 1950-1992 (MSS 232)

Restrictions: Laboratory notebooks and research files containing medical records are restricted until the year 2067. Files containing administrative files are restricted until 2084.

Extent: 16 Linear feet (41 archives boxes)

Papers of Robert N. Hamburger, UCSD professor of pediatrics and researcher in allergy and immunology. Hamburger investigated the relationship between peptides and immunoglobulin E (IgE) antibodies and synthesized human IgE pentapeptide (HEPP), a substance shown to inhibit allergic response. Included in the collection are laboratory notebooks (1960-1984), extensive research files on Hamburger's allergy studies, correspondence, and Food and Drug Administration documents related to animal and human testing. Also included are business files related to Allergy Peptide Company, Inc. (APCo, Inc.); Cytotech, Inc.; Immunetech, Inc.; Immunetech Research Partners; and Syntex Corporation, biotechnology firms that attempted to develop HEPP as a commercial product. The collection also contains biographical materials, writings, lectures, correspondence, and materials related to Hamburger's involvement in professional organizations. The later accessions include UCSD administrative documents including committtee materials and documents related to the history of the School of Medicine.

Robert N. Hamburger was born in New York on January 26, 1923. He received his B.A. in zoology and chemistry in 1947 from the University of North Carolina and attended Yale University School of Medicine (1947-1951), where he conducted research on LE cells. Hamburger carried out his medical residency at Strong Memorial Hospital in Rochester, N.Y., and Yale University School of Medicine. Between 1960 and 1963, as a Special Fellow of the National Institutes of Health, he studied molecular genetics and immunology in the UCSD Department of Biology. In 1964, he was appointed associate professor of pediatrics at the UCSD School of Medicine and served as its Assistant Dean for Faculty and Curriculum Affairs (1964-1969). In 1967, during a six-month semi-sabbatical at Guy's Hospital Medical School, London, he studied the development of immunologic systems in the human newborn. Hamburger was appointed head of the Pediatric Immunology and Allergy Division of the UCSD School of Medicine in 1969.

Hamburger's laboratory research with immunoglobin E (IgE) during the early 1970s led to the synthesis of a peptide, human immunoglobin E pentapeptide (HEPP), that inhibited allergic reaction in a limited "in vivo" test. He published his findings in an article in Science (August 1, 1975) entitled "Peptide Inhibition of the Prausnitz-Kustner Reaction." The University of California obtained two patents for HEPP: "Polypeptide Agents for Blocking the Human Allergic Response" (1976) for the peptide, and "Method for Blocking Allergic Response" (1979) for a method of delivery. In March of 1977, amid optimism over HEPP's potential as a cure for allergy sufferers, Syntex Corporation, a Palo Alto biotechnology firm, bought the rights and a two year research option to develop HEPP as a product. Syntex dropped the project after a year and a half when no suitable test animal could be found to replicate human response. In 1978, Hamburger entered into an option agreement with the University of California and formed APCo, Inc. (Allergy Peptide Company, Inc.), with the purpose of advancing his research through the first stages of FDA approval.

In 1981, Hamburger and UCSD doctors Richard O'Connor and Gary Hahn formed Immunetech Research Partners to finance further stages of the peptide research. This partnership purchased the assets of APCo, Inc., including all of its research materials and, signed a research and development agreement with Immunetech, Inc., a separate company formed with venture capitalist Ray McKewon of the Enterprise Management Company. Immunetech, Inc., then purchased both UC-owned patents and attempted to develop HEPP as a product but eventually dropped the project. Hamburger was the first executive vice president of Immunetech, Inc., and was involved in research and development until 1985.

Robert Hamburger retired from UCSD in 1990 as emeritus professor and continues to conduct private research and development activities.

The Robert Hamburger Papers document allergy and immunology research in Hamburger's laboratory at UCSD and the development of human IgE pentapeptide (HEPP). The collection contains laboratory notebooks (1960-1984), research materials on Hamburger's peptide studies, FDA documents, patent and grant material, and writings by Hamburger and others. Also included are business records and agreements with: APCo, Inc.; Cytotech, Inc.; Immunetech, Inc.; Immunetech Research Partners; Enterprise Management Company; and Syntex Corporation, biotechnology firms associated with the development of HEPP. Other materials include UCSD administrative files and development documents for the School of Medicine.

SERIES 1: BIOGRAPHICAL MATERIAL

The BIOGRAPHICAL MATERIAL series contains directory entries, Hamburger's curriculum vitae, news clippings, photographs, correspondence from his sabbatical leave at Guys Hospital, London, a journal of medical notes from Strong Memorial Hospital, and material from Yale University's 25th Class Reunion Symposium .

SERIES 2: RESEARCH MATERIAL

The RESEARCH MATERIAL series constitutes the bulk of the collection and is arranged in four subseries: A) Laboratory Notebooks, B) Laboratory Subject Files, C) Patent Files, and D) Grant Files.

A) The Laboratory Notebooks subseries contains laboratory research data compiled at UCSD by Hamburger, his colleagues and graduate students from 1960-1984. The notebooks contain lupus studies, immune kill studies, immunoglobulin E (IgE) and diphtheria assays, lymphocyte transformation studies, and peptide research data. The notebooks are arranged chronologically. The majority of notebooks in this series contain medical records and are restricted.

B) The Laboratory Subject Files (1962-1989) subseries contains laboratory notes, general laboratory correspondence, FDA correspondence, and FDA documents. Research contained in this subseries was conducted primarily at UCSD; however, some clinical trials where carried out at other institutions and, in some cases, sponsored by private firms including APCo, Inc., Immunetech, Inc., and the Schering Corporation. The majority of data in this subseries consists of peptide studies and HEPP (human IgE pentapeptide) trials on animals and humans, including subcutaneous testing, toxicology tests, ophthalmic solution testing, and intranasal solution tests. Other studies include Albuterol research, diphtheria-tetanus tests and a twin study. The files are arranged chronologically.

C) The Patent Files subseries is arranged chronologically and contains patent-related correspondence (1974-1986), agreements between the University of California and APCo, Inc., and drafts of Hamburger's two patents entitled "Polypeptide Agents for Blocking the Human Allergic Response" (1976) and "Method for Blocking Allergic Response" (1979).

D) The Grant Files subseries contains documentation of research grants from the National Institutes of Health (1962-1979) and the University of California, San Diego (1965 and 1977). Also included is one unfunded grant proposal to the American Cancer Society (1969).

SERIES 3: WRITINGS BY HAMBURGER

This series, which includes a bibliography of Hamburger's writings, is arranged in three subseries: A) Abstracts and Reprints, B) Talks and Lectures and C) Book Reviews for Journals.

A) The Abstracts and Reprints subseries is arranged alphabetically by title and contains materials dated 1950-1986. Included are draft chapters 1-10 of an unpublished book entitled "Pediatric Immunology and Allergy" and writings on passive immune kill, immunoglobulin E (IgE) and other immunology and allergy-related topics.

B) The Talks and Lectures subseries is arranged alphabetically by title and contains materials dated 1965-1983. Presented at various meetings and classes, materials include manuscript drafts, typescripts, lists of slides, and some correspondence. Lecture topics include immunoglobulin E (IgE), human IgE pentapeptide (HEPP) and other research associated with allergy and immunology.

C) The Book Reviews for Journals subseries is arranged alphabetically by title of journal and contains book reviews by Hamburger for , , , and . Materials in this series, which include correspondence, are dated 1977-1985. SERIES 4: WRITINGS OF OTHERS

This series is arranged alphabetically by author and includes writings by other authors that Hamburger annotated.

SERIES 5: BIOTECHNOLOGY DEVELOPMENT FIRMS

This series documents the participation of biotechnology and investment firms in developing HEPP as a commercial product and is arranged in six subseries: A) APCo. Inc. (Allergy Peptide Company, Inc.); B) Cytotech, Inc.; C) McKewon and Timmons Investment Bankers; D) Immunetech, Inc.; E) Immunetech Research Partners; and, F) Syntex Corporation.

A) The APCo, Inc. (Allergy Peptide Company, Inc.), subseries is arranged alphabetically and contains business documents and correspondence from its establishment in 1978 by Robert Hamburger through its dissolution in 1982. For APCo, Inc., sponsored research studies see Series 2. RESEARCH MATERIAL.

B) Cytotech, Inc., is arranged alphabetically and contains Hamburger's consulting and shareholder materials, including reports, business documents and correspondence dated 1981-1988.

C) McKewon and Timmons Investment Bankers is arranged alphabetically and contains correspondence and shareholder materials dated 1983-1987. Prior to McKewon and Timmons, Ray McKewon was affiliated with the Enterprise Mangement Company, which was involved in business agreements with Immunetech, Inc., and Immunetech Research Partners. Those materials are located in the following two subseries.

D) Immunetech, Inc., is arranged alphabetically and contains business agreements, correspondence, financial reports, meeting agendas, meeting minutes, and shareholder materials dated 1976-1992. Materials dated 1981 to 1985 reflect Hamburger's primary involvment with this company, including its establishment and initial business negotiations. For Immunetech, Inc., sponsored research studies see Series 2. RESEARCH MATERIAL.

E) Immunetech Research Partners is arranged alphabetically and contains business agreements and shareholder materials dated 1981-1982. Most of these materials document the first year of this partnership (1981) between Robert Hamburger, Richard O'Connor and Gary Hahn.

F) Syntex Corporation is arranged alphabetically and contains a consulting agreement with Hamburger, a license agreement with the University of California Regents and a press release regarding the company, all of which are dated 1976. For Syntex Corporation sponsored research studies see Series 2. RESEARCH MATERIAL.

SERIES 6: PROFESSIONAL ORGANIZATIONS

Arranged alphabetically, this series contains correspondence, committee rosters and meeting materials for professional organizations in which Hamburger participated. Among the organizations represented are: the American Academy of Allergy and Immunology; the American Academy of Pediatrics; the American College of Allergy and Immunology; the California Medical Association; the Nuffield Foundation; the San Diego County Medical Society; and, the Western Society for Pediatric Research.

SERIES 7: UCSD GENERAL CAMPUS

The UCSD GENERAL CAMPUS files are documents pertaining to subjects relating to the administration of the campus and how they relate to the School of Medicine. Subjects include building of the campus, development of academic programs, the activities of individual departments and institutes, and committees Hamburger participated in, at the campus and systemwide levels. The files are arranged alphabetically.

The series also includes Hamburger's files on the UCSD Chamber Music Series. The files, labeled "Quartet Series," detail Hamburger's involvement in beginning, planning, and supporting the series. Materials include correspondence, programs, notes, planning documents, tickets, and clippings for the series that has evolved into UCSD's ArtPower! Chamber Music Series.

SERIES 8: UCSD SCHOOL OF MEDICINE

The materials of the UCSD SCHOOL OF MEDICINE, arranged alphabetically, are administrative and developmental files documenting Hamburger's involvement with committees, curriculum, residency training, and the Basic Medical Sciences building advisement. Included are several folders pertaining to the history of the school of medicine with interviews, events, and planning.

SERIES 9: ORIGINS OF THE SCHOOL OF MEDICINE AT UCSD

Documents include the correspondence and typescripts for the UCSD School of Medicine memoir, Origins of the School of Medicine at UCSD , written by Robert Hamburger and the one day symposium (November 1, 1984) transcript drafts and correspondence. The personalized history document honored both the 25th Anniversary of the founding of UCSD and the 20th Anniversary of the School of Medicine. Participants of the symposium included Herbert York, Clark Kerr, Roger Revelle, John Galbraith, Robert Hamburger, and Joseph Stokes.

Container List

BIOGRAPHICAL MATERIAL

Box 1 Folder 1
Biographical materials published in various directories, 1965 - 1968
Box 1 Folder 2
Committee service lists, 1966 - 1968
Box 1 Folder 3
Curriculum vita, 1981
Box 1 Folder 4
News clippings, 1965 - 1985
Box 1 Folder 5
Photographs of Robert N. Hamburger, 1975
Box 1 Folder 6-7
Sabbatical correspondence, A-Z, 1967
Box 1 Folder 8
Strong Memorial Hospital journal of medical notes, 1952 - 1953
Box 1 Folder 9
Yale University 25th Reunion Class Symposium, 1976

RESEARCH MATERIAL

Laboratory Notebooks

Box 2 Folder 1
1960 October 23 - September 28: Workbook
Box 2 Folder 2-3
1961-1963: Auto Ab and Lupus Studies
Box 2 Folder 4-6
1962: Hela H and R Study, raw data
Box 2 Folder 7
1963 January 28 - June 18: Hela H and R Immune Kill Study, raw data - Book II
Box 2 Folder 8
1963 August 26 - 1964 May 30: Passive Immune Kill - Book III
Box 3 Folder 1
1966 February 8 - December 14: Book VIII - Robert Hamburger and J. Douglass

Restrictions Apply

Box 3 Folder 2
1966 December 13 - 1967 November 7: UCSD School of Medicine - R. Hamburger and J. Douglass

Restrictions Apply

Box 3 Folder 3
1967 July 1 - December 15: Book I - Robert Hamburger

Restrictions Apply

Box 3 Folder 4
1968 December 19 - 1969 July 23: Antibody Binding Extracorporeal, Book I - Michael Bazaral
Box 3 Folder 5
1970 July 10 - 1972 June: Hemagglutination Assay/Thyroglobulin Immunoabsorbtion - Michael Slaughter

Restrictions Apply

Box 3 Folder 6
1970 August 27 - 1971 March 4: Immunoglobin Assays - M. Bazaral, R. Hamburger and H. A. Orgel

Restrictions Apply

Box 4 Folder 1
1970 December 2 - 1972: Twin Study ledger book

Restrictions Apply

Box 4 Folder 2
1971 January 10 - 1973 February 2: Book 6 - Michael Bazaral

Restrictions Apply

Box 4 Folder 3
1971 February 16 - October 21: Hospital Quantitative IgE Studies and Results - C. Ashcraft

Restrictions Apply

Box 4 Folder 4
1971 June 17 - August 23: IgE

Restrictions Apply

Box 4 Folder 5
1971 September 14 - 1972 May 4: IgE Assays I - Eva Lydick

Restrictions Apply

Box 4 Folder 6
1972 January 20 - June 19: Book 3 - Eva Lydick

Restrictions Apply

Box 4 Folder 7
1972 January 20 - 1977 May 31: Immunizations and Bleedings
Box 5 Folder 1
1972 February - 1973 May 30: H. Alice Orgel

Restrictions Apply

Box 5 Folder 2
1972 March 14: Navy Babies/IgE Levels of Newborns - Michael Lenoir and H. Alice Orgel

Restrictions Apply

Box 5 Folder 3
1972 May 10 - 1973 January 10: IgE Assays II - Eva Lydick

Restrictions Apply

Box 5 Folder 4
1972 October 19 - 1973 October 30: Diphtheria Assay I

Restrictions Apply

Box 5 Folder 5
1972 December 1 - 1973 March 31: Laboratory Notes - Robert Hamburger

Restrictions Apply

Box 5 Folder 6
1973 January 17 - 1974 March 29: IgE Assays III - Eva Lydick

Restrictions Apply

Box 5 Folder 7
1973 June 25 - 1974 March 8: Book 7 - Eva Lydick

Restrictions Apply

Box 6 Folder 1
1973 October 31 - 1976 June 10: Diphtheria Assay II - Book 2

Restrictions Apply

Box 6 Folder 2
1974 January 18 - 1975 June 24: Mad Scientist - Harvey Gorrin

Restrictions Apply

Box 6 Folder 3
1974 March 13 - October 15: IgE Assays IV - Robert Hamburger

Restrictions Apply

Box 6 Folder 4
1974 June 4 - 1975 August 14: Mason I - Donna Mason

Restrictions Apply

Box 6 Folder 5
1974 July 10 - 1976 May 18: Precipitins to Milk and Precipitins to Aspergillus - Lab Book 1

Restrictions Apply

Box 6 Folder 6
1974 October 21 - 1975 January 7: IgE Assay V
Box 6 Folder 7
1974 December 19 - 1975 September 2: IgE Double Ab Assay

Restrictions Apply

Box 7 Folder 1
1975 January 4 - 1983 January: Immunoglobulins

Restrictions Apply

Box 7 Folder 2
1975 October 7 - 1976 July 17: BSB 4033 Book II - Robert Wilcsek

Restrictions Apply

Box 7 Folder 3
1976 June 1 - 1979 September 21: Milk Precipitins and Hypersensitivity Pneumonitis - Lab Book 2

Restrictions Apply

Box 7 Folder 4
1976 August 26 - 1982 July 29: Pediatric Immunology and Allergy Division - D. Mason, D. Melvin and M. Wiley

Restrictions Apply

Box 7 Folder 5
1976 September 29 - 1978 January 4: IgE Double Ab Assay

Restrictions Apply

Box 7 Folder 6
1976 November 17 - 1977 July 14: Histamine/IgE Assays

Restrictions Apply

Box 8 Folder 1
1977 January 24 - August 23: Lymphocyte Transformation Studies I - Sylvia Johnson

Restrictions Apply

Box 8 Folder 2
1977 June 20 - August 22: Lymphocyte Transformation and Rosettes Patients I - Sylvia Johnson

Restrictions Apply

Box 8 Folder 3
1977 June 20 - August 22: Lymphocyte Transformation and Rosettes Patients II - Sylvia Johnson

Restrictions Apply

Box 8 Folder 4
1978 July 19 - 1979 March 21: Basophil Degranulation Inhibition by Pentapeptide - Bob Ziering

Restrictions Apply

Box 8 Folder 5
1979 October 25 - 1980 April 30: Etiologic Role of Allergic Rhinitis in Serous Otitis Media - D. Cook, H. Ort

Restrictions Apply

Box 8 Folder 6
1980 July 28 - 1985 August 2: Lymphocyte Transformation - Book IV

Restrictions Apply

Box 8 Folder 7
1981 February 10 - 1982 August 10: Diphtheria Assay - Book IV

Restrictions Apply

Box 9 Folder 1
1981 February 12 - 1983 March 16: Pediatric Immunology and Allergy Division - Hector Heredia

Restrictions Apply

Box 9 Folder 2
1981 April 22 - November 23: Pediatric Immunology and Allergy Division/Kaiser study - Quants, IgA, M and G

Restrictions Apply

Box 9 Folder 3
1981 September 12 - December 14: Peptide Research - John Bastian

Restrictions Apply

Box 9 Folder 4
1981 October 13 - 1982 March 23: ISP - Diana Hu

Restrictions Apply

Box 9 Folder 5
1982 July 12 - 1983 February 7: Diphtheria E.I.A

Restrictions Apply

Box 9 Folder 6
1982 December 21 - 1984 September 10: Serum Free Media, Human Dagmara Tubelis

Restrictions Apply

Box 9 Folder 7
1983 March 7 - May 4: Pediatric Immunology and Allergy Division, lab data - Hector Heredia
Box 10 Folder 1
1983 March 11 - June 22: Peptide Studies - Maryetta Hornbeck

Restrictions Apply

Box 10 Folder 2
1983 November 7 - 1984 May 29: AIDS Study

Restrictions Apply

Box 10 Folder 3
1984 January 5 - December 22: RAST Worksheets

Restrictions Apply

Laboratory Subject Files

Box 11 Folder 1
1962: Tissue culture summary data
Box 11 Folder 2-5
1964 - 1967: Correspondence
Box 11 Folder 6
1967: Lab result photos, urea/glycine gel
Box 11 Folder 7
1968: Correspondence
Box 11 Folder 8
1970: IgE mother-baby study
Box 11 Folder 9
1970-1972: Twin study

Restrictions Apply

Box 11 Folder 10
1974: Correspondence
Box 11 Folder 11
1974: Disophrol and it's components in seasonal allergic rhinitis study
Box 11 Folder 12-14
1974-1978: Albuterol studies - Schering Corporation
Box 11 Folder 15
1974-1979: Allergy in infants study

Restrictions Apply

Box 11 Folder 16
1975: Correspondence - FDA
Box 11 Folder 17
1975: Correspondence - General laboratory
Box 11 Folder 18
1975: In vitro pentapeptide tests, 1-7
Box 11 Folder 19
1975: Peptide displacement experiment
Box 11 Folder 20
1975: Peptide inhibition of allergy study
Box 11 Folder 21
1975: Peptide stability study, electrophoresis strip photos - Peninsula Laboratories, Inc
Box 11 Folder 22
1975-1977: Peptide studies - Syntex Corporation
Box 11 Folder 23
1976: Correspondence - FDA
Box 11 Folder 24
1976: Correspondence - General laboratory
Box 11 Folder 25
1976: IgE low level assay
Box 11 Folder 26
1976: Notice of claimed investigational exemption for a new drug - Pentapeptide D-S-D-P-R
Box 11 Folder 27
1976: Statement of investigator - Pentapeptide D-S-D-P-R
Box 12 Folder 1
1976: Thymosin in primary cellular immunodeficiencies protocol
Box 12 Folder 2
1976: Vaceril studies - Schering Corporation
Box 12 Folder 3
1976-1983: HEPP clinical studies summary, part I
Box 12 Folder 4
1976-1983: HEPP clinical studies summary, part II
Box 12 Folder 5
1977: Correspondence - FDA
Box 12 Folder 6
1977: Correspondence - General laboratory
Box 12 Folder 7
1978: Correspondence - FDA
Box 12 Folder 8
1978: FDA inspection
Box 12 Folder 9
1978: Peptides quality control records - Peninsula Laboratories, Inc
Box 12 Folder 10
1978-1979: Cyclic amp/gmp notes
Box 12 Folder 11
1978-1979: Passive immunity notes
Box 12 Folder 12
1978-1980: IgE low level studies
Box 12 Folder 13
1978-1980: Skin tests/radio allergosorbent test (RAST) results

Restrictions Apply

Box 12 Folder 14
1978-1983: Human IgE pentapeptide toxicology summary
Box 12 Folder 15
1979: Correspondence - FDA
Box 12 Folder 16
1979: Correspondence - General laboratory
Box 12 Folder 17
1979: HEPP inhibition of allergy study - APCo, Inc
Box 12 Folder 18
1979: IgE PRIST studies
Box 12 Folder 19
1979: Lab notes
Box 12 Folder 20
1979: Notice of claimed investigational exemption for a new drug - Pentapeptide D-S-D-P-R
Box 12 Folder 21
1979-1980: HEPP studies

Restrictions Apply

Box 12 Folder 22
1979-1984: HEPP clinical study summaries
Box 12 Folder 23
1980: Amino acid electrophoresis data
Box 13 Folder 1
1980: Correspondence - FDA
Box 13 Folder 2
1980: Correspondence - General laboratory
Box 13 Folder 3
1980: FDA inspection
Box 13 Folder 4
1980: Guidelines for the evaluation of endogenous peptides and their analogs
Box 13 Folder 5
1980: IgE/radio allergosorbent test (RAST) - Kaiser study

Restrictions Apply

Box 13 Folder 6
1980: Kallstad comparison data
Box 13 Folder 7
1980: Milestones document
Box 13 Folder 8
1980-1981: Enzyme immunoassay for immunoglobulin E study - CalBiochem
Box 13 Folder 9
1980-1981: Immunoradiometric assay for IgE - Hybritech, Inc
Box 13 Folder 10
1981: Correspondence - FDA
Box 13 Folder 11
1981: Correspondence - General laboratory
Box 13 Folder 12
1981: IgE research results - Hybritech, Inc

Restrictions Apply

Box 13 Folder 13
1981: Peptide nomenclature
Box 13 Folder 14
1981: Research results

Restrictions Apply

Box 13 Folder 15
1981-1982: Efficacy and safety comparison study of choledyl and theodur tablets - Warner Lambert/Parke Davis
Box 13 Folder 16
1981-1982: HEPP research results - UCLA Statistical/Biomathematical Consulting Center

Restrictions Apply

Box 13 Folder 17-18
1981-1983: HEPP therapeutic trial (25-day, 38 patient) double-blind, randomly selected, placebo-controlled
Box 13 Folder 19
1981-1983: Intranasal toxicity test in rabbits via nasal spray - Immunetech, Inc
Box 13 Folder 20
1982: Amino acid electrophoresis data
Box 13 Folder 21
1982: Correspondence - FDA
Box 14 Folder 1
1982: Correspondence - FDA
Box 14 Folder 2
1982: Correspondence - General laboratory
Box 14 Folder 3
1982: Efficacy of HEPP protein in the treatment of allergy
Box 14 Folder 4
1982: FDA inspection
Box 14 Folder 5
1982: HEPP acute intravenous toxicity study in mice
Box 14 Folder 6-7
1982: HEPP trial (14-day, 12 patient) double-blind, dose response, placebo-controlled

Restrictions Apply

Box 14 Folder 8-11
1982-1984: HEPP phase II, double-blind, randomized, placebo-controlled
Box 14 Folder 12
1982-1984: IgA and IgE research data
Box 14 Folder 13
1983: Clr = ClEs function
Box 14 Folder 14
1983: Correspondence - FDA
Box 14 Folder 15
1983: Correspondence - General laboratory
Box 15 Folder 1
1983: Diphtheria-tetanus test results

Restrictions Apply

Box 15 Folder 2
1983: HEPP subacute subcutaneous toxicity study in rats
Box 15 Folder 3
1983: IgE egg research data
Box 15 Folder 4
1983: SAI inspection of toxicological testing facility
Box 15 Folder 5
1983-1984: HEPP intranasal administration, double-blind study
Box 15 Folder 6-7
1983-1984: HEPP phase II study results and phase III clinical protocol - Immunetech, Inc
Box 15 Folder 8-9
1983-1984: HEPP phase III, subcutaneous, double-blind, randomized, placebo-controlled
Box 15 Folder 10-11
1983-1986: HEPP three-year plan, volumes I & II
Box 16 Folder 1
1984: Correspondence - FDA
Box 16 Folder 2
1984: Correspondence - General laboratory
Box 16 Folder 3
1984: HEPP metabolism studies
Box 16 Folder 4
1984: HEPP rabbit teratology - Science Applications, Inc
Box 16 Folder 5
1984: HEPP rat subchronic toxicology - Science Applications, Inc
Box 16 Folder 6
1984: HEPP safety and efficacy in patients with perennial allergic rhinitis
Box 16 Folder 7
1984: HEPP USAN listing request
Box 16 Folder 8
1984: Milk-specific IgA E.I.A
Box 16 Folder 9
1984: Notice of claimed investigational exemption for a new drug - Pentapeptide D-S-D-P-R, Immunetech, Inc
Box 16 Folder 10
1984-1986: HEPP ophthalmic clinical study - Immunetech, Inc
Box 16 Folder 11
1985: Correspondence - General laboratory
Box 16 Folder 12
1985: Diphtheria-tetanus test results

Restrictions Apply

Box 16 Folder 13
1985: HEPP double-blind study of the effect of 3 weeks of treatment on the nasal provocation test - Merck
Box 16 Folder 14
1985: HEPP ophthalmic solution

Includes notice of claimed investigational exemption, animal toxicology results and ophthalmic solution clinical protocol - Immunetech, Inc.

Box 16 Folder 15
1985: HEPP ophthalmic solution phase II clinical results - Immunetech, Inc
Box 16 Folder 16
1985: HEPP summary of data on the efficacy and tolerance
Box 16 Folder 17
1985: Statement of investigator - Pentapeptide D-S-D-P-R
Box 16 Folder 18
1986: Clinical advantages of HEPP over conventional antiallergy drugs - Draft report
Box 16 Folder 19
1986: Correspondence - General laboratory
Box 16 Folder 20
1986: Diphtheria-tetanus test results

Restrictions Apply

Box 16 Folder 21
1986: HEPP bioavailability study
Box 16 Folder 22
1986: HEPP for injection study
Box 16 Folder 23
1986: HEPP intranasal phase III study
Box 16 Folder 24
1986: HEPP ophthalmic solution dose range clinical trial summary
Box 16 Folder 25
1986: HEPP ophthalmic solution test results

Restrictions Apply

Box 17 Folder 1
1989: Nasal NDA summary, clinical section - Immunetech, Inc
Box 17 Folder 2
1989: Pentyde nasal solution three week safety and efficacy study - Immunetech, Inc
Box 17 Folder 3
Undated: Mitogen stim. indexes

Restrictions Apply

Box 17 Folder 4
Undated: Unidentified laboratory notes

Patent Files

Box 17 Folder 5
1963: Agreement with the University of California
Box 17 Folder 6
1974-1975: Correspondence
Box 17 Folder 7
1976: Correspondence
Box 17 Folder 8
1976: Polypeptide Agents for Blocking the Human Allergic Response - Patent
Box 17 Folder 9
1977: Application amendment
Box 17 Folder 10-12
1977-1979: Correspondence
Box 17 Folder 13
1979: Method for Blocking Allergic Response - Patent
Box 17 Folder 14
1979: Option agreement

Agreement for APCo's commercial development of Robert Hamburger's UC-owned patent entitled: Polypeptide Agents for Blocking the Human Allergic Response.

Box 17 Folder 15
1980-1981: Correspondence
Box 17 Folder 16
1982: Agreement with the University of California
Box 17 Folder 17
1982: Correspondence
Box 17 Folder 18
1983-1986: Correspondence

Grant Files

Box 17 Folder 19
1962-1967: Genetics course - National Institutes of Health
Box 17 Folder 20
1964: Research grant - National Institutes of Health
Box 17 Folder 21
1964-1971: Immune Kill and Cells in Tissue Culture - National Institutes of Health
Box 18 Folder 1
1964-1971: Immune Kill and Cells in Tissue Culture - National Institutes of Health
Box 18 Folder 2
1965: Research grant - University of California, San Diego
Box 18 Folder 3
1969: Antigenic Enhancement by Foreign Haptens - American Cancer Society (not funded)
Box 18 Folder 4
1971: Genetics of Immunoglobulin E - National Institutes of Health
Box 18 Folder 5
1976-1977: Development and Genetics of IgE and Allergy - National Institutes of Health
Box 18 Folder 6
1977: Atopy and IgE Synthesis - National Institutes of Health
Box 18 Folder 7
1977: Safety and Toxicity of Synthetic IgE - University of California, San Diego
Box 18 Folder 8
1979: Biomedical Research Support Grant - National Institutes of Health
Box 18 Folder 9
Undated: Development of Immunoglobulin E - National Institutes of Health

WRITINGS BY ROBERT HAMBURGER

Abstracts and Reprints

Box 18 Folder 10
Robert Hamburger's bibliography, 1950 - 1978
Box 18 Folder 11
All About Allergy Shots - Abstract, 1976
Box 18 Folder 12
Allergy and the Immune System - Reprint, 1976
Box 18 Folder 13
Anaphylaxis-like Reactions to Corticosteroid Therapy - Photocopy of original article, 1974
Box 18 Folder 14
Antigenic Determinants on the Chloramphenicol Molecule - Abstract, undated
Box 18 Folder 15
Antigenic Specifications Acquired From the Growth Medium by Cells in Tissue Culture - Reprint, 1963
Box 18 Folder 16
Atmospheric Pollen and Spore Sampling in San Diego, California - Reprint, 1976
Box 18 Folder 17-18
Chloramphenicol-Specific Antibody - Abstract & reprint, 1966
Box 18 Folder 19
Clonal Growth of Primary Human Cell Cultures - Reprint, 1964
Box 18 Folder 20
Conservation of Active Sites in Molecules with Immunoglobulin Fold Domain Structure - Reprint. (Chapter 16 of Immunologic Analysis), undated
Box 18 Folder 21
Current Status of the Clinical and Immunologic Consequences of a Prototype Allergic Disease Prevention Program - Typescript, 1983
Box 18 Folder 22
Development and Inheritance of IgE and Allergy - Reprint, 1974
Box 18 Folder 23
Development and Inheritance of IgE Mediated Hypersensitivity - Typescript, 1978
Box 18 Folder 24
Development of Atopic Allergy in Children - Reprint, 1980
Box 18 Folder 25
Development of Gamma Globulins in the Human Newborn - Abstract, 1968
Box 18 Folder 26-27
Development of IgE and Allergy in Infancy - Typescript & reprint, 1974
Box 18 Folder 28
Diagnosis and Prophylaxis of Atopic Allergic Diseases in the First Three Years of Life - Reprint, 1979
Box 18 Folder 29
Evolutionary Relationship of Thymopoietin to Immunoglobulins and Cellular Recognition Molecules - Reprint, 1981
Box 18 Folder 30
Genetics of IgE and Allergy: Serum IgE Levels in Twins - Reprint, 1974
Box 18 Folder 31
IgE and Allergy - Reprint, 1976
Box 18 Folder 32
IgE Levels in Normal Infants and Mothers and an Inheritance Hypothesis - Reprint, 1971
Box 18 Folder 33
Immunoglobulin E in Leprosy - Abstract, undated
Box 18 Folder 34
Induction of the Lupus Erythematosus ("L.E.") Cell In Vitro in Peripheral Blood - Reprint, 1950
Box 18 Folder 35
Inhibition by IgE Pentapeptide of IgE Rosette Formation by Human Basophils - Abstract, 1982
Box 18 Folder 36
Inhibition of IgE Binding to Tissue Culture Cells and Leucocytes by Pentapeptide - Photocopy of original article, 1979
Box 18 Folder 37
Metabolism of IgE in Transfused Infants - Abstract, 1974
Box 18 Folder 38
New Experimental Approaches to the Therapy of Atopic Diseases - Galley proof & reprint, 1983
Box 18 Folder 40
New Means for Serum IgE Levels Result from Changes in Measurement Methodology - Abstract, 1979
Box 18 Folder 41
Newer Bronchodilators - Abstract, undated
Box 18 Folder 42
Niveles de Immunoglobulina E, Herencia a la Alergia e Inmunidad a las Helmintos - Photocopy of original article, 1973
Box 18 Folder 43
Of Many Things... And the Immune System - Reprint, 1978
Box 18 Folder 44
Office Diagnosis of Immunodeficiency Disease - Typescript, undated
Box 18 Folder 45-46
Passive Immune Kill and Pseudo-Autoimmune Disease: Proposed Model for Chloramphenicol Induced Aplastic Anemia - Correspondence, 1967-1968
Box 18 Folder 47-49
Passive Immune Kill of Cells in Tissue Culture - Correspondence, reprint & typescript, 1965

Pediatric Immunology and Allergy

Box 18 Folder 50
Chapter 1: Introduction - Draft, undated
Box 18 Folder 51
Chapter 2: Human Fetal Immune System - Draft, undated
Box 18 Folder 52
Chapter 3: Development of Antigen Responses in the Fetus - Draft, undated
Box 19 Folder 1
Chapter 3: Reference articles
Box 19 Folder 2
Chapter 5: Development in the First Year of Life - Draft, undated
Box 19 Folder 3
Chapter 5: Reference articles
Box 19 Folder 4
Chapter 6: Strategy of Immunizations - Draft, undated
Box 19 Folder 5
Chapter 6: Reference articles
Box 19 Folder 6
Chapter 7: Some Genetics of the Immune System - Draft, undated
Box 19 Folder 7
Chapter 7: Reference articles
Box 19 Folder 8
Chapter 8: Draft, undated
Box 19 Folder 9
Chapter 8: Reference articles
Box 19 Folder 10
Chapter 9: Pages 7-9 only - Draft, undated
Box 19 Folder 11
Chapter 10: Laboratory Techniques - Draft, undated
Box 19 Folder 12
Correspondence, 1979
Box 19 Folder 13
Peptide Inhibition of the Prausnitz-Kustner Reaction - Reprint, 1975
Box 19 Folder 14
Prophylaxis of Allergy - Abstract, 1976
Box 19 Folder 15
Prophylaxis of Allergy in Infants Debate - Abstract, undated
Box 19 Folder 16-17
Radio Allergosorbent Test (RAST) and Skin Tests in Low IgE Individuals - Abstract & research notes for writing, 1979 - 1980 & undated
Box 19 Folder 18
Recent Studies with Human IgE Pentapeptide (HEPP) - Reprint, 1981
Box 19 Folder 19
Regulation and Measurement of IgE in Atopy - Typescript, undated
Box 19 Folder 20-22
Results of a Double-Blind Randomly Selected Placebo-Controlled Therapeutic Trial of Human IgE Pentapeptide - Abstract, undated
Box 19 Folder 23
Safety and Efficacy of Human IgE Pentapeptide - Abstract, 1984
Box 19 Folder 24
Separation of Electophoretic Bands from a Bence-Jones Protein - Abstract, 1968
Box 19 Folder 25
Some New Studies With Human IgE Pentapeptide (HEPP) - Abstract, undated
Box 19 Folder 26
Standardization and Stability of Immunoglobulin E (IgE) - Reprint, 1972
Box 19 Folder 27
Statement from UCSD to the California Senate Fact Finding Committee of Public Health and Safety - Typescript, 1966
Box 19 Folder 28
Studies of Human IgE Pentapeptide: HEPP - Reprint, 1980
Box 19 Folder 29-30
Transfused Immunoglobulin E in Newborns, Letter to the Editor - Photocopy of original article & typescript, 1982
Box 19 Folder 31
Unidentifiable notes, figures and tables used in miscellaneous writings, undated
Box 19 Folder 32
Untitled, undated writing
Box 19 Folder 33
Use of the Laboratory in the Diagnosis of Allergic Disease - Photocopy of original article, 1986
Box 19 Folder 34
Value of PRIST, RAST and Skin Tests in Selected Individuals - Abstract, undated

Talks and Lectures

Box 19 Folder 35
List of talks and lectures by Robert Hamburger, 1965 - 1968
Box 19 Folder 36
Allergic Tissue Damage and Foreign Anitgens - Typescript, 1969

Presented at the 4th Nuffield Conference on Rheuatism, Oxfordshire, England.

Box 19 Folder 37
Allergy, Immunology and the Inheritance of IgE Levels - Typescript, 1971

Presented at a West Coast Allergy Society meeting.

Box 19 Folder 38
Allergy, Pathology Lecture - Handwritten introduction and list of slides for lecture, 1982
Box 19 Folder 39
Allergy Physician's Assistant (APA) Training Program - Abstract, 1975

Presented at an American Academy of Allergy meeting.

Box 19 Folder 40
Allergy Testing for the Primary Care Physician - Typescript outline, 1982

Presented at the 26th Annual Symposium of the San Diego Academy of Family Physicians.

Box 19 Folder 41
Atopic Asthma - List of slides, 1980

Presented at a meeting in Medellin, Columbia.

Box 19 Folder 42
Atopy, Hypersensitivity or Allergy - Handwritten draft, 1976

Presented to Core Medical Education students.

Biologic Basis For a New Therapeutic Approach to Allergic Disease

Box 19 Folder 43
Abstract, 1975

Presented at an American Academy of Allergy meeting and the Second Charles Blackley Symposium.

Box 19 Folder 44
List of slides, undated

Presented at the Second Charles Blackley Symposium.

Box 19 Folder 45
Biology of IgE - List of slides, 1977

Presented at Pomona College, California.

Box 19 Folder 46
Blockade of Mast Cell Receptors for the Treatment of Human Allergies - Handwritten draft, 1976

Presented at a Canadian Society of Allergy and Clinical Immunology meeting.

Box 19 Folder 47
Clinical Manifestations of Atopy - List of slides, 1977

Presented to a Pathology class.

Box 19 Folder 48
Development and Genetics of IgE and Allergy - Typescript, 1976

Presented at a joint meeting of the Northern California Section of the American Association of Clinical Chemists and the California Association of Bioanalysts.

Box 19 Folder 49
Development and Inheritance of IgE Mediated Hypersensitivity - List of slides, 1978

Presented at USC's Practical Allergy and Immunology Conference.

Box 19 Folder 50
Development of IgE and Allergy - Handwritten outline, 1975

Presented to biology students at Mar Vista High School, San Diego.

Development of IgE and Allergy During the First Year of Life: Preliminary Data

Box 19 Folder 51
Abstract, 1974

Presented at the 30th Annual American Academy of Allergy Meeting.

Box 19 Folder 52
Correspondence, 1973 - 1974
Box 19 Folder 53
Research notes for lecture, 1974
Box 19 Folder 54
Development of IgE in Infancy and Childhood - Handwritten draft, 1975

Presented at a West Coast Allergy Society meeting.

Box 19 Folder 55
Development of the IgE Allergy System and it's Effect on Subsequent Atopic Allergy - Typescript and slide list

Undated.

Box 19 Folder 56
Developmental Immunology and Allergy in the First Two Years of Life - Handwritten draft, 1975

Presented at a March of Dimes sponsored event at Sunrise Hospital, Las Vegas, Nevada.

Box 19 Folder 57
Diagnostic Update in Allergy - Handwritten outline and list of slides, 1977

Presented at Paradise Valley Hospital, San Diego for the Core Medical Education Program.

Box 19 Folder 58
Diagnostic Value and Problems of Skin Tests, PRIST and RAST and Food Allergy - Tables used in lecture, 1980

Presented at a meeting in Monterrey, Mexico.

Box 19 Folder 59
Dose Response to Human IgE Pentapeptide (HEPP) - Abstract, 1983

Presented at the 39th Annual Congress of the American College of Allergists, New Orleans, Louisiana.

Box 20 Folder 1
Effect of Oral Albuterol on Plasma Cyclic Adenosine Monophosphate - Abstract, 1975

Presented at an American Academy of Allergy meeting.

Box 20 Folder 2
Experience with Carnation Hypoallergenic Formula - Typescript, 1988

Presented at the Food Allergy Symposium, New York.

Box 20 Folder 3
Genetics and Allergy - Typescript, 1982

Presented at the Southwest Allergy Symposium.

Box 20 Folder 4
IgE and Allergy - List of slides, 1974

Presented at the U.S. Naval Hospital, Pediatrics Department, San Diego.

Box 20 Folder 5
IgE and HEPP on the Wil-2 WT Cell (lecture 1) and Mechanism and Inheritance of Allergy (lecture 2), 1978

Contains list of slides for both lectures. Presented at a meeting in Birmingham and to Core Medical Education students.

Box 20 Folder 6
IgE, Biology and Clinical Activity - List of slides, 1974

Presented at the U.S. Naval Hospital, Dermatology Department, San Diego.

Box 20 Folder 7
IgE Blocking Peptide - Handwritten draft, 1975

Presented at the San Diego Pulmonary Society Conference.

Box 20 Folder 8
IgE in Allergy - Handwritten draft and list of slides, 1973
Box 20 Folder 9
IgE in Food Allergy - Typescript and photocopies of slides, undated
Box 20 Folder 10
IgE, Peptides and Allergy - Handwritten draft, 1975

Presented at Grand Rounds, University Hospital, San Diego.

Box 20 Folder 11
Immune Response to Chloramphenicol - Typescripts in English and Spanish, undated
Box 20 Folder 12
Immunization - Handwritten outline, 1966

Presented at a Peace Corp meeting.

Box 20 Folder 13
Immunodeficiency and Allergic States - Handwritten outline, 1980

Presented at a meeting in Acapulco.

Box 20 Folder 14
Immunologic Deficiency Disease - Handwritten outline and list of slides, 1975

Presented at Doctor's Hospital, San Diego.

Box 20 Folder 15
Immunology of Breast Milk and Phophylaxis of Allergy - Handwritten draft, 1979

Presented at the Pediatric Grand Rounds, University Hospital, San Diego.

Box 20 Folder 16
Immunotherapy - List of slides, undated
Box 20 Folder 17
Improved Screening Method for Anti-Chloramphenicol Antibodies - Abstract, 1970

Presented at the 17th Annual Western Society for Pediatric Research meeting, Carmel, California.

Box 20 Folder 18
Indications for Hyposensitization, Desensitization, Injection Therapy, and Immunotherapy - Handwritten outline, 1974

Presented at the U.S. Naval Hospital, Pediatrics Department, San Diego.

Box 20 Folder 19
International Meeting of Asthmology lecture - Typescript in English and Spanish, 1974

Presented at the Interasma Conference, Havana, Cuba.

Box 20 Folder 20
Is it Immune Deficiency or Just a Bad Winter? Typescript outline, 1982
Box 20 Folder 21
Joseph Weiner, M.D. Memorial Lecture - Handwritten draft introduction, 1983

Presented at St. Raphael Hospital, Milford, Connecticut.

Box 20 Folder 22
Journal Club Lecture - Handwritten draft introduction, 1966

Presented at Children's Hospital of Orange County, California.

Box 20 Folder 23
Los Angeles Allergy Society Lecture - Handwritten draft introductions, 1 - 3, 1975
Box 20 Folder 24
Management of Asthma - Handwritten draft, 1978

Presented as an American Academy of Pediatrics Core Medical Education Course, University Hospital, San Diego.

Box 20 Folder 25
More About IgE Than You'd Care to Know - Handwritten draft and list of slides, 1975
Box 20 Folder 26
Once Around [the World] - Handwritten draft, 1978
Box 20 Folder 27
Paramedical Aspects of Medical Treatment of Chest Diseases - Typescript, 1978

Presented at the Interasthma Congress.

Box 20 Folder 28
Pediatric Allergy - List of slides, 1980
Box 20 Folder 29
Peptide Inhibition of Allergic Reaction - List of slides, 1976
Box 20 Folder 30
Prediction, Prevention and Treatment of Allergic Asthma - Handwritten draft, 1976

Presented at John D. Spreckles Lodge, San Diego. Sponsored by the Lung Association of San Diego and Imperial Counties.

Box 20 Folder 31
Preparation for General Pediatrics and Sub-Specialty Training - Typescript, undated

Presented at the Congresos De Pediatria, Mexico.

Box 20 Folder 32
Present and Future in Treatment of Allergic Diseases - List of slides, 1980

Presented at a meeting in Medellin, Colombia.

Box 20 Folder 33
Prophylaxis of Allergy in Infants Debate - Handwritten outline and list of slides, 1976

Presented at an immunology conference.

Box 20 Folder 34
Prophylaxis of Atopic Asthma in the First Two Years of Life - Typescript, 1978

Presented at the IX Interasthma Congress, New Orleans, Louisiana.

Pseudo-Autoimmune Disease

Box 20 Folder 35
Correspondence, 1965 - 1966
Box 20 Folder 36
Typescript, 1965

Presented at the XI International Congress of Pediatrics, Tokyo, Japan.

Box 20 Folder 37
Radio Allergosorbent Test (RAST) - List of slides, 1981

Presented at the Second Annual Course on Selected Topics in Immunology, School of Medicine, University of Guadalajara.

Box 20 Folder 38
Serum Assays for Antigen Specific IgE Antibody - Handwritten introduction and list of slides, 1981

Presented at an American College of Allergists meeting.

Box 20 Folder 39
Sickle Cell Anemia - Handwritten outline, 1969

Presented at a Charles Drew Foundation meeting.

Box 20 Folder 40
T-Cell Modulation of IgE Production - Handwritten introduction and list of slides, 1980

Presented at a West Coast Allergy Society meeting, Acapulco.

Box 20 Folder 41
Treatments of the Future - Handwritten introduction and list of slides, 1977

Presented at the VII Congreso Medico Estatal, Tijuana, Mexico.

Box 20 Folder 42
UCSD Allergy in Infancy Study: An Interim Report - Typescript and list of slides, 1978

Presented at a West Coast Allergy Society meeting.

Box 20 Folder 43
Understanding Allergy - Handwritten draft, 1976

Presented at the UCSD Medical Center Auxiliary Health Education Lecture Series.

Box 20 Folder 44
Values and Problems with PRIST and RAST in Children - Abstract, 1979

Presented at the American Academy of Pediatrics Annual Meeting.

Box 20 Folder 45
What Can Our Friends the Animals Tell Us About IgE Mediated Disease in Humans? Handwritten draft, 1975

Presented at a Journal Club meeting.

Box 20 Folder 46
Where Are We and Where Are We Going in Allergy? Handwritten note cards, undated
Box 20 Folder 47-48
Untitled lectures - Handwritten drafts and typescripts, 1973 - 1981

Book Reviews for Journals

Box 20 Folder 49
, 1977 - 1985
Box 20 Folder 50
, 1979 - 1985
Box 20 Folder 51
, 1977
Box 20 Folder 52
, 1973

WRITINGS OF OTHERS

Box 20 Folder 53
List of writings of others kept on Robert Hamburger's desk, undated
Box 20 Folder 54-55
Annotated by Robert Hamburger, A - H
Box 21 Folder 1-2
Annotated by Robert Hamburger, I - V
Box 21 Folder 3
Unidentified authors

BIOTECHNOLOGY DEVELOPMENT FIRMS

APCo, Inc. (Allergy Peptide Company, Inc.)

Box 21 Folder 4
Business documents, 1978 - 1982
Box 21 Folder 5
Correspondence, 1981 - 1982
Box 21 Folder 6
Deed of gift to the UC Regents, 1982
Box 21 Folder 7
Income tax returns, 1981 - 1982
Box 21 Folder 8
Joint venture proposal from Immunoscience Corp., 1979
Box 21 Folder 9
Option agreement, 1979

Cytotech, Inc.

Box 21 Folder 10
Amended and Restated Articles of Incorporation, 1987
Box 21 Folder 11
Brochure, 1983
Box 21 Folder 12
Correspondence, 1982 - 1988
Box 21 Folder 13
Human complement product list, 1985
Box 21 Folder 14
News clippings of Cytotech, Inc., 1984 - 1985
Box 21 Folder 15
News clippings of other companies, 1981
Box 21 Folder 16-17
Private Placement Memorandum, 1982 - 1984
Box 22 Folder 1
Product proposals, undated
Box 22 Folder 2-4
Report and financial statements, 1983 - 1988
Box 22 Folder 5
Resolution Amending Articles of Incorporation as to Series B Convertible Preferred Stock, undated
Box 22 Folder 6
Series B Convertible Preferred Stock Purchase Agreement, 1984
Box 22 Folder 7
Series B Convertible Preferred Stock Registration Rights Agreement, 1984
Box 22 Folder 8
Shareholder Consent Form, 1989
Box 22 Folder 9
Unidentified report, undated

McKewon and Timmons Investment Bankers

Box 22 Folder 10
Correspondence, 1983 - 1987
Box 22 Folder 11
News clippings, 1984
Box 22 Folder 12
Private Placement Memorandum, 1983
Box 22 Folder 13
Quarterly reports, 1984 - 1986

Immunetech, Inc.

Box 22 Folder 14
Agreement for Purchase and Sale of Assets between Robert Hamburger, APCo, Inc. and Immunetech, Inc., 1981
Box 22 Folder 15
Agreements between Herbert S. Lightstone and Immunetech, Inc., 1982 - 1984
Box 22 Folder 16
Balance sheet, 1984
Box 22 Folder 17
Brochures, undated
Box 22 Folder 18
Business plan, 1983
Box 22 Folder 19
Business plan summary, 1989 - 1992
Box 22 Folder 20
Certificate of Amendment of Articles of Incorporation, 1982
Box 22 Folder 21
Company logo photograph, 1981
Box 22 Folder 22
Confidential Disclosure Agreement, undated
Box 22 Folder 23-25
Corporate overview, 1982 - 1983

Correspondence

Box 23 Folder 1
Accounts payable, 1988
Box 23 Folder 2
Administrative office, 1986 - 1988
Box 23 Folder 3
Bausch and Lomb, Inc., 1985
Box 23 Folder 4
Blair, James, 1985
Box 23 Folder 5
Brucker, Donald, 1982 - 1985
Box 23 Folder 6
Down, Lisa and Norman, 1983
Box 23 Folder 7
Dura Pharmaceuticals, 1990
Box 23 Folder 8
Hahn, Gary S, 1981 - 1985
Box 23 Folder 9
Himel, G, 1982
Box 23 Folder 10
Kornberg Associates, 1983
Box 23 Folder 11
Lightstone, Herbert S, 1983 - 1986
Box 23 Folder 12
Lyon and Lyon Law Offices, 1983
Box 23 Folder 13
McKewon, Ray, 1981 - 1986
Box 23 Folder 14
Merck, E., undated
Box 23 Folder 15
Nelson, Norman, 1982
Box 23 Folder 16
O'Connor, Richard, 1982
Box 23 Folder 17
Pallai, Peter, 1981
Box 23 Folder 18
Phillips and Phillips, Attorneys at Law, 1981 - 1982
Box 23 Folder 19
Plummer, James, 1985
Box 23 Folder 20
Ramseier, Gordon, 1988
Box 23 Folder 21-22
Rangus, Kathryn, 1983 - 1987
Box 23 Folder 23
Richieri, Steven P, 1989
Box 23 Folder 24
Schmidt, Todd W, 1986 - 1989
Box 23 Folder 25
Shareholder materials, 1984 - 1991
Box 23 Folder 26
UCSD Office of Contract and Grant Administration, 1982
Box 23 Folder 27
Yakatan, Gerald J, 1989
Box 23 Folder 28
Development and License Agreement between Bausch and Lomb, Inc. and Immunetech, Inc., 1985
Box 23 Folder 29
Employment agreement, undated
Box 23 Folder 30
Expenses and financing, 1981 - 1986
Box 24 Folder 1-2
Financial statements, 1981 - 1986
Box 24 Folder 3
Human Complement System Proposal, 1982
Box 24 Folder 4
Investigator brochure, 1988
Box 24 Folder 5
Loan and Equity Investment Agreement, 1986
Box 24 Folder 6
Meetings 1981: Board of Directors (first) meeting - Minutes
Box 24 Folder 7
Meetings 1981: Research meeting - Agenda
Box 24 Folder 8
Meetings 1982: Building planning meeting - Minutes
Box 24 Folder 9
Meetings 1982: Meeting agendas
Box 24 Folder 10-12
Meetings 1983-1985: Board of Directors meetings - Agendas and minutes
Box 24 Folder 13
Meetings 1985: FDA meeting - Agenda and minutes
Box 24 Folder 14
Meetings 1985: Research presentation schedules
Box 24 Folder 15
Meetings 1985: Scientific Advisory Board meetings - Agendas and minutes
Box 24 Folder 16
Meetings 1986: Board of Directors meetings - Agendas and minutes
Box 24 Folder 17
Meetings 1986: Scientific Advisory meetings - Agendas
Box 24 Folder 18
Meetings 1987: Scientific Advisory meeting - Agenda
Box 24 Folder 19
Meetings 1987-1990: Shareholder meetings - Announcements
Box 24 Folder 20
News clippings, 1976 - 1990
Box 24 Folder 21
Notes on business and research, 1982 - 1986
Box 24 Folder 22
Private Placement Memorandum, 1984
Box 25 Folder 1-2
Private Placement Memorandum, 1985 - 1986
Box 25 Folder 3
Product Agreement with Merck, 1986
Box 25 Folder 4
Promissary Notes, 1985
Box 25 Folder 5
Proposal for the Acquisition of ABC Pharmaceuticals by Immunetech Pharmaceuticals, 1989
Box 25 Folder 6
Proposal to Endow a Chair in the Pediatric Immunology and Allergy Division, UCSD School of Medicine, 1982
Box 25 Folder 7
Report and financial statements, 1982 - 1983
Box 25 Folder 8
Restated Articles of Incorporation, 1986 - 1989
Box 25 Folder 9
Retainer Agreement with Enterprise Management Company, 1981
Box 25 Folder 10
Securities and Exchange Commission Registration Statement, 1984
Box 25 Folder 11
Securities Purchase Agreement, 1986
Box 25 Folder 12-13
Stockholder documents, 1981 - 1991
Box 25 Folder 13
Stockholder documents, 1986 - 1991
Box 25 Folder 14
Technology Sharing Agreement between Immunetech, Inc. and Cytotech, Inc., 1982
Box 25 Folder 15
Unanimous Written Consent of Directors, 1986
Box 25 Folder 16
Weingart Protein Sequencer Laboratory results, 1983

Immunetech Research Partners

Box 25 Folder 17
Agreement between Immunetech Research Partners and the Enterprise Management Company, 1981
Box 25 Folder 18
Comprehensive Option Agreement between Immunetech Research Partners and Immunetech, Inc., 1981
Box 25 Folder 19
Discussion of Management's Proposal for Immunetech Research Partners "Roll Up", 1983
Box 25 Folder 20
Escrow Instructions, 1981
Box 25 Folder 21
Fictitious Business Name Statement, 1981
Box 25 Folder 22
License Agreement, draft, 1981
Box 25 Folder 23
Partnership Agreements between R. Hamburger, R. O'Connor and G. Hahn to form Immunetech Research Partners, 1980 - 1981
Box 26 Folder 1
Private Placement Memorandum, June 1981
Box 26 Folder 2
Private Placement Memorandum, July 1981
Box 26 Folder 3
Proposed Concept for a New Business, 1980 - 1981
Box 26 Folder 4
Quarterly Progress Reports, 1982
Box 26 Folder 5
Research and Development Agreement between Immunetech Research Partners and Immunetech, Inc., 1981
Box 26 Folder 6
Retainer Agreement, 1981
Box 26 Folder 7
Special Report, 1982
Box 26 Folder 8
Technology License Agreement between Immunetech Research Partners and Immunetech, Inc., 1981

Syntex Corporation

Box 26 Folder 9
Consulting Agreement between Syntex and Robert Hamburger, 1976
Box 26 Folder 10
License Agreement between Syntex and University of California Regents, 1976
Box 26 Folder 11
Press release, 1976

PROFESSIONAL ORGANIZATIONS

American Academy of Allergy

Box 26 Folder 12
Correspondence, 1976 - 1980
Box 26 Folder 13
In Vitro Tests Committee, research data, meeting agendas and minutes, 1976
Box 26 Folder 14
American Academy of Allergy and Immunology - Correspondence, rosters and meeting minutes, 1980 - 1990
Box 26 Folder 15
American Academy of Pediatrics - Correspondence, 1978 - 1980
Box 26 Folder 16
American Association for Clinical Immunology and Allergy - Correspondence, 1978 - 1981
Box 26 Folder 17
American College of Allergists - Correspondence, 1980 - 1986
Box 26 Folder 18
American College of Allergy and Immunology - Correspondence and committee list, 1988 - 1990
Box 26 Folder 19
American Pediatric Society - Correspondence, 1972 - 1982
Box 26 Folder 20
California Committee on Therapeutic Abortion - Correspondence, 1966 - 1969
Box 26 Folder 21
California Medical Association - Correspondence, 1982 - 1983
Box 26 Folder 22
California Society of Allergy and Clinical Immunology - Correspondence, 1972 - 1990
Box 26 Folder 23
Children's Hospital Education Committee - Correspondence, 1968
Box 26 Folder 24
Clinica de Salubridad de Campesinos - Correspondence, 1974 - 1981
Box 26 Folder 25
First Mexican-American Congress of Clinical Immunology and Allergy - Correspondence and meeting materials, 1981
Box 27 Folder 1
Interasma - Correspondence, 1978 - 1988
Box 27 Folder 2
Los Angeles Society of Allergy and Clinical Immunology - Correspondence, 1976
Box 27 Folder 3
North County Health Services - Correspondence, 1980 - 1982
Box 27 Folder 4
Nuffield Foundation 4th Nuffield Conference on Rheumatism - Correspondence, meeting and travel materials, 1969