Harvey Itano Papers, 1946 - 2000 (MSS 0226)

Extent: 3.8 Linear feet (10 archive boxes)

Papers of Harvey Itano, American biochemist and pioneer in the study of sickle cell anemia hematology. The collection documents Itano's research on sickle cell anemia disease and his work in the field of molecular medicine focusing on understanding of genetic and molecular basis of blood pathologies and hereditary diseases.

Harvey Akio Itano was born on November 3, 1920, in Sacramento, California, the eldest son of Masao and Sumako (Nakahara) Itano. Itano attended University of California, Berkeley, and graduated in 1942 with highest honors in chemistry. Due to President Roosevelt's anti-Japanese campaign following Pearl Harbor, Itano with his family was sent to the desolate Tule Lake camp. While in the camp, Itano kept applying to medical schools throughout the country. With assistance from the National Japanese American Student Relocation Council, Itano was released from the camp to attend St. Louis School of Medicine. In 1945, Itano received his M.D. and continued Ph.D. studies at the California Institute of Technology in biochemistry where he studied and worked with Linus Pauling.

Itano is known for his pioneering work with sickle cell anemia disease, the topic assigned to him as a Ph.D. thesis topic by Linus Pauling. Sickle cell anemia disease is a hereditary disease commonly found among people of African descent. Itano tried several different physical and chemical methods to distinguish normal hemoglobin from sickle cell hemoglobin and finally he was able to demonstrate the difference by using electrophoresis. At that time, electrophoresis was a new technique that allowed researchers to separate molecules according to their electrical charge and Itano found a slight difference in electrophoretic mobility between normal and sickle cell hemoglobins. That led to understanding that patients with sickle cell anemia have a different type of hemoglobin than healthy individuals and thus a cause of a disease was traced to a molecule. Later, this inspired Vernon Ingram's seminal discovery of a single amino acid difference between normal and sickle cell hemoglobin and allowed him to explain a hemoglobin abnormality by an alteration in genes. After completing the project, Itano continued to work in the field of molecular medicine and published extensively about genetic and molecular basis of other blood pathologies and hereditary diseases.

Itano was awarded Eli Lilly Award in Biological Chemistry (1954) and Martin Luther King Jr. Medical Achievement Award (1972) for his pioneering work on sickle cell anemia disease. He is a member of the National Academy of Sciences (1979), American Academy of Arts and Sciences (1998), American Society of Biochemistry and Molecular Biology, Biochemistry Society (London), Phi Beta Kappa, Sigma Xi, and Alpha Omega Alpha.

Itano is professor emeritus in the Department of Pathology at UCSD and resides in La Jolla, California.

The papers of Harvey Itano, an American biochemist, document his pioneering research on sickle cell anemia and his work in the field of molecular medicine focusing on understanding of genetic and molecular basis of blood pathologies and hereditary diseases. Well represented in the papers are his laboratory notebooks and reprints of his journal publications. Of special interest are notebooks documenting his electrophoresis experiments that led to the discovery of a slight difference in electrophoretic mobility between normal and sickle cell hemoglobins and allowed him to explain the cause of the disease on a molecular basis. Also included are correspondence files with his colleagues in the field of molecular medicine, especially letters from Linus Pauling dating from 1946 to 1986.

The papers are arranged in five series: 1) MISCELLANEOUS MATERIALS, 2) CORRESPONDENCE, 3) NOTEBOOKS, 4) WRITINGS BY ITANO, and 5) MATERIALS RE: LINUS PAULING.

SERIES 1) MISCELLANEOUS MATERIALS

The MISCELLANEOUS MATERIALS series comprises materials providing biographical information and contains curriculum vitae with a list of publications, biographical forms, and articles mentioning Itano's work.

SERIES 2) CORRESPONDENCE

The CORRESPONDENCE series documents Itano's communication with colleagues in the field of molecular medicine. The materials are arranged in two subseries: A) Chronological Files and B) Alphabetical Files.

A) The Chronological Files (1969-1986) subseries primarily contains outgoing correspondence sent from Itano's office to his colleagues and professional journals.

B) The Alphabetical Files (1946-2000) subseries contains correspondence documenting Itano's election to the American Academy of Arts and Sciences and American Chemical Society, nomination to Martin Luther King Jr. Medical Achievement Award, letters from Linus Pauling, and correspondence with scholars who wrote about Pauling.

SERIES 3) NOTEBOOKS

The NOTEBOOKS subseries documents Itano's laboratory experiments and is arranged in five subseries: A) Composition Notebooks (1948-1986), B) Electrophoresis Experiments (1952-1953), C) Green Notebooks (1954-1969), D) Black Notebooks (1959-1976), and E) Brown Notebooks (1961-1962).

SERIES 4) WRITINGS BY ITANO

The WRITINGS BY ITANO subseries comprises of reprints of his journal publications. Also included is a copy of his Ph.D. dissertation and a few typescripts.

SERIES 5) MATERIALS RE: LINUS PAULING

Announcements and broadsides of events dedicated to Linus Pauling and photocopies of newspaper and magazine articles discussing life and work of Pauling.

Harvey Itano Personal Correspondence & Memorabilia, MSS 755. Special Collections & Archives, UC San Diego.

Container List

MISCELLANEOUS MATERIALS

Box: 1 Folder: 1
Biographical information

Contains curriculum vitae, supplementary biographical forms, biography submitted for WHO'S WHO IN AMERICA, and photocopies of articles discussing Itano's work.

CORRESPONDENCE

Chronological Files

Box: 1 Folder: 2
1969-1971
Box: 1 Folder: 3
1972
Box: 1 Folder: 4
1973
Box: 1 Folder: 5
1974
Box: 1 Folder: 6
1975
Box: 1 Folder: 7
1976
Box: 1 Folder: 8
1977
Box: 1 Folder: 9
1978
Box: 1 Folder: 10
1979
Box: 1 Folder: 11
1980
Box: 1 Folder: 12
1981
Box: 1 Folder: 13
1982
Box: 1 Folder: 14
1983
Box: 1 Folder: 15
1984
Box: 2 Folder: 1
1985
Box: 2 Folder: 2
1986

January - April.

Box: 2 Folder: 3
1986

May - December.

Alphabetical Files

Box: 2 Folder: 4
American Academy of Arts and Sciences, 1998
Box: 2 Folder: 5
American Chemical Society, 2000
Box: 2 Folder: 6
Bengelsdorf, Irving S., 1994
Box: 2 Folder: 7
Goertzel, Victor, 1980
Box: 2 Folder: 8
Heller, Paul, 1994
Box: 2 Folder: 9
Linus Pauling Festschrift Volume, 1966 - 1968
Box: 2 Folder: 10
Owen, Ray, 1994 - 1995
Box: 2 Folder: 11
Pauling Kamb, Linda, 1995
Box: 2 Folder: 12
Pauling, Linus, 1946 - 1966
Box: 2 Folder: 13
Pauling, Linus, 1969 - 1986
Box: 2 Folder: 14
Shellan, Jeffrey B., 1996
Box: 2 Folder: 15
Southern Christian Leadership Conference - Sickle Cell Anemia - Awards Banquet, 1972

Contains correspondence and biographical notes about Itano.

Box: 2 Folder: 16
University of California, Berkeley - Berkeley Convocation - Japanese American Alumni Association, 1992
Box: 2 Folder: 17
Wills, Chris, 1997
Box: 2 Folder: 18
Zewail, Ahmed H., 1989 - 1990

NOTEBOOKS

Composition Notebooks, 1948 - 1986

Box: 2 Folder: 19
1948

Chemistry 259a.

Box: 3 Folder: 1
1950 - 1952

Enzyme Kinetics, Physical Methods of Protein Chemistry.

Box: 3 Folder: 2
1952 - 1954

51 Crellin.

Box: 3 Folder: 3
1972
Box: 3 Folder: 4
1972 - 1974
Box: 3 Folder: 5
1972 - 1974
Box: 3 Folder: 6
1973
Box: 3 Folder: 7
1973 - 1976
Box: 3 Folder: 8
1977
Box: 4 Folder: 1
1977 - 1979
Box: 4 Folder: 2
1979 - 1981
Box: 4 Folder: 3
1982 - 1986

Electrophoresis Experiments, 1952 - 1953

Box: 4 Folder: 4
August 13, 1952 - January 27, 1953
Box: 4 Folder: 5
October 16, 1952 - January 13, 1953
Box: 4 Folder: 6
January 16 - June 26, 1953
Box: 4 Folder: 7
January 28 - May 15, 1953
Box: 4 Folder: 8
April 30 - June 10, 1953
Box: 4 Folder: 9
May 18 - July 27, 1953
Box: 4 Folder: 10
August 24 - August 27, 1953
Box: 5 Folder: 1
October 6, 1953
Box: 5 Folder: 2
October 7, 1953

Green Notebooks, 1954 - 1969

Box: 5 Folder: 3
1954 - 1957
Box: 5 Folder: 4
1954 - 1967
Box: 5 Folder: 5
1955 - 1957
Box: 5 Folder: 6
1956 - 1958
Box: 5 Folder: 7
1958 - 1959
Box: 6 Folder: 1
1966
Box: 6 Folder: 2
1967
Box: 6 Folder: 3
1967 - 1968
Box: 6 Folder: 4
1969
Box: 6 Folder: 5
Undated
Box: 7 Folder: 1
Undated

Black Notebooks, 1959 - 1976

Box: 7 Folder: 2
Black Laboratory Book, 1959 - 1961
Box: 7 Folder: 3
Black Laboratory Book, 1962 - 1964
Box: 7 Folder: 4
Black Laboratory Book, 1963 - 1965
Box: 7 Folder: 5
Black Laboratory Book, 1964 - 1966
Box: 8 Folder: 1
Black Laboratory Book, 1967
Box: 8 Folder: 2
Black Laboratory Book, 1967 - 1968
Box: 8 Folder: 3
Black Laboratory Book, 1972 - 1976

Brown Notebooks, 1961 - 1962

Box: 8 Folder: 4
1961 - 1962
Box: 8 Folder: 5
1962

WRITINGS BY ITANO

Box: 8 Folder: 6
Rapid Diagnostic Test For Sickle Cell Anemia, 1949

January. With Linus Pauling. Published in THE JOURNAL OF HEMATOLOGY, Vol. 14, No. 1. Contains reprint.

Box: 8 Folder: 7
Sickle Cell Anemia, a Molecular Disease, 1949

November 25. With Linus Pauling, S.J. Singer and Ibert C. Wells. Contains a reprint and a photocopy of the republished paper in SELECTED PAPERS ON MOLECULAR GENETICS, edited by J. Herbert Taylor, 1965.

Box: 8 Folder: 8
New Inherited Abnormality Of Human Hemoglobin, 1950

November. With James V. Neel. Published in the PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES. Contains reprint.

Box: 8 Folder: 9
Contributions To the Study Of Sickle Cell Hemoglobin, 1950

Ph.D. Thesis. Contains typescript.

Box: 8 Folder: 10
Ratio Of Sickle Cell Anemia Hemoglobin To Normal Hemoglobin In Sicklemics, 1951

January. With Ibert C. Wells. Published in THE JOURNAL OF BIOLOGICAL CHEMISTRY, Vol. 188, No. 1. Contains typescript.

Box: 9 Folder: 1
Familial Differences In the Proportion Of Abnormal Hemoglobin Present In the Sickle Cell Trait, 1951

October. With James V. Neel and Ibert C. Wells. Published in THE JOURNAL OF CLINICAL INVESTIGATIONS, Vol. XXX, No. 10. Contains reprint.

Box: 9 Folder: 2
Notes On a Proposed Therapeutic Program For Sickle Cell Anemia, 1952

January, 21. Contains typescript.

Box: 9 Folder: 3
Chronic Hemolytic Anemia Associated With Thalassemia and Sickling Traits, 1952

March. With Phillip Sturgeon and William N. Valentine. Published in THE JOURNAL OF HEMATOLOGY, Vol. VII, No. 3. Contains reprint.

Box: 9 Folder: 4
Third Abnormal Hemoglobin Associated With Hereditary Hemolytic Anemia, 1951

December. Published in the PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, Vol. 37, No. 12. Contains reprint.

Box: 9 Folder: 5
Hemolytic Anemia Presumably Due To Coexistence Of the Genes For Thalassemia and Sickling, 1952

With John S. Lawrence and James V. Neel. Published in TRANSACTIONS OF THE ASSOCIATION OF AMERICAN PHYSICIANS, Vol. LXV. Contains reprint.

Box: 9 Folder: 6
Human Hemoglobin, 1953

January, 30. Published in SCIENCE. Contains reprint.

Box: 9 Folder: 7
Electrophoretic Studies Of Globins Prepared From Normal Adult and Sickel Cell Hemoglobins, 1953

February. With E. Havinga. Published in the PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES. Contains reprint.

Box: 9 Folder: 8
Qualitative and Quantitative Control Of Adult Hemoglobin Synthesis - A Multiple Allele Hypothesis, 1953

March. Published in AMERICAN JOURNAL OF HUMAN GENETICS, Vol. 5, No. 1. Contains reprint.

Box: 9 Folder: 9
Two Cases Of Sickle Cell Disease Presumably Due to the Combination of the Genes For Thalassemia..., 1953

May. With James V. Neel and John S. Lawrence. Published in BLOOD, THE JOURNAL OF HEMATOLOGY, Vol. VIII, No. 5. Contains reprint.

Box: 9 Folder: 10
Solubilities Of Naturally Occuring Mixtures Of Human Hemoglobin, 1953

November. Published in ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, Vol. 47, No. 1. Contains reprint.

Box: 9 Folder: 11
Identification Of a Fourth Abnormal Human Hemoglobin, 1954

March 22. With W.R. Bergren and Phillip Sturgeon. Published in THE JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. Contains reprint.

Box: 9 Folder: 12
Zone Electrophoresis Of Abnormal Hemoglobins, 1954

With William R. Bergren and Phillip Sturgeon. Published in ACTA HAEMATOLOGICA. Contains reprint.

Box: 9 Folder: 13
Clinical Manifestations Of Inherited Abnormal Hemoglobins, 1955

May. With Phillip Sturgeon and William R. Bergren. Published in THE JOURNAL OF HEMATOLOGY. Contains reprint.

Box: 9 Folder: 14
Genetic and Biochemical Studies Of "Intermediate" Types Of Cooley's Anemia, 1955

July. With Phillip Sturgeon and William R. Bergren. Published in BRITISH JOURNAL OF HAEMATOLOGY, Vol. 1, No. 3. Contains reprint.

Box: 9 Folder: 15
Clinical States Associated With Alterations Of the Hemoglobin Molecule, 1955

September. With Bethesda. Contains reprint.

Box: 9 Folder: 16
Abnormal Human Hemoglobins, 1956

May 2. With William R. Bergren and Phillip Sturgeon. Published in MEDICINE, Vol. 35, No. 2. Contains reprint.

Box: 9 Folder: 17
Hemoglobin J, 1956

May 18. With Oscar A. Thorup, Munsey Wheby and Byrd S. Leavell. Published in SCIENCE, Vol. 723, No. 3203. Contains reprint.

Box: 9 Folder: 18
Hyposthenuria In Sickle Cell Anemia: A Reversible Renal Defect, 1956

September. With H.G. Keitel and D. Thompson. Published in THE JOURNAL OF CLINICAL INVESTIGATION, Vol. XXXV, No. 9. Contains reprint.

Box: 9 Folder: 19
Demonstration Of Intermediate Forms Of Carbonmonoxy and Ferrihemoglobin..., 1956

November. With Elizabeth Robinson. Published in THE JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. Contains reprint.

Box: 9 Folder: 20
Hemoglobins, 1956

Published in ANNUAL REVIEW OF BIOCHEMISTRY, Vol. 25. Contains reprint.

Box: 9 Folder: 21
Hemoglobin Intermediates, 1957

March. With Elizabeth Robinson. Published in FEDERATION PROCEEDINGS, Vol. 16, No.1. Contains reprint.

Box: 9 Folder: 22
Electrophoretic Analyses Of the Abnormal Human Hemoglobins, 1957

May 2 - 3. Published in the PROCEEDINGS OF THE CONFERENCE ON HEMOGLOBIN. Contains reprint.

Box: 9 Folder: 23
Interpretation Of Electrophoretic, Solubility and Denaturation Data In the Study Of Hemoglobin Differences, 1957

September. Published in FEDERATION PROCEEDINGS, Vol. 16, No. 3. Contains reprint.

Box: 9 Folder: 24
Abnormal Hemoglobin Molecules In Relation To Disease, 1957

With Linus Pauling. Published in SATRYK URSVENSK KEMISK TIDSKRIFT. No. 69. Contains reprint.

Box: 9 Folder: 25
Human Hemoglobins: Their Properties and Genetic Control, 1957

Published in ADVANCES IN PROTEIN CHEMISTRY, Vol. XII. Contains reprint.

Box: 9 Folder: 26
Specificity In the Interaction Of Sickle Cell Hemoglobin Molecules, 1957

Published in MOLECULAR STRUCTURE AND BIOLOGICAL SPECIFICITY; Pub. No. 2. Contains reprint.

Box: 9 Folder: 27
On Dissociation and Recombination Of Human Adult Hemoglobins A, S and C, 1958

June. With S. J. Singer. Published in the PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES. Contains reprint.

Box: 9 Folder: 28
On the Asymmetrical Dissociation Of Human Hemoglobin, 1958

December 16. With S. J. Singer. Published in the PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, Vol. 45, No. 2. Contains reprint.

Box: 9 Folder: 29
Electrophoretic Separation Of Intermediate Compounds In Two Reactions Of Ferrihemoglobin, 1958

With E. Robinson. Published in BIOCHIMICA ET BIOPHYSICA ACTA, Vol. 29. Contains reprint.

Box: 9 Folder: 30
Constituents Of Human Hemoglobin, 1959

June 27. With E. Robinson. Published in NATURE, Vol. 183. Contains reprint.

Box: 9 Folder: 31
Formation Of Normal and Doubly Abnormal Hemoglobins By Recombination Of Hemoglobin I With S and Cb, 1959

June 27. Published in NATURE, Vol. 183. Contains reprint.

Box: 9 Folder: 32
Properties and Inheritance Of Hemoglobin By Asymmetrical Recombination, 1959

November 7. With E. Robinson. Published in NATURE, Vol. 184. Contains reprint.

Box: 9 Folder: 33
Chemical and Genetical Units Of the Hemoglobin Molecule, 1959

With S. J. Singer and E. Robinson. Published in the Proceedings of Ciba Foundation Symposium on Biochemistry of Human Genetics. Contains typescript.

Box: 9 Folder: 34
Asymmetrical Recombination Of Alkali - Dissociated Hemoglobin Mixtures, 1959

February 20. With E. Robinson. Published in NATURE, Vol. 185, No. 4712. Contains reprint.

Box: 9 Folder: 35
Specific Recombination Of the Subunits Of Hemoglobin, 1960

August 31. With E. Robinson. Published in ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, Vol. 88. Contains reprint.

Box: 9 Folder: 36
Genetic Control Of the Polypeptide Chains Of Hemoglobin, 1960

September 4 - 10. With E. A. Robinson. Published in the Proceedings of the VIIth International Congress of Hematology, held in Tokyo, Japan. Contains reprint.

Box: 9 Folder: 37
Genetic Control Of the Alpha and Beta Chains Of Hemoglobin, 1960

November. With Elizabeth A. Robinson. Published in the PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, Vol. 46, No. 11. Contains reprint.

Box: 9 Folder: 38
Identification Of the Recombinant Products Of Canine and Human Hemoglobins, 1960

December 3. With E. A. Robinson. Published in NATURE, Vol. 188, No. 4753. Contains reprint.

Box: 9 Folder: 39
Thalassemia and the Abnormal Human Hemoglobins, 1961

July 22. With Linus Pauling. Published in NATURE, Vol. 191, No. 4786. Contains reprint.

Box: 9 Folder: 40
Evidence For Coordination Of Monophenyl With Heme Proteins, 1961

With E. A. Robinson. Published in THE JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vol. 83, No. 3339. Contains reprint.

Box: 9 Folder: 41
Blocking Of Tryptic Cleavage Of Arginyl Bonds By the Chemical Modification Of the Guanido Group With Benzil, 1963

With A. J. Gottlieb. Published in BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol. 12, No. 5. Contains reprint.

Box: 9 Folder: 42
Dissociation and Association Of Hemoglobin Subunits, 1964

With E. A. Robinson and A. J. Gottlieb. Published in SUBUNIT STRUCTURE OF PROTEINS BIOCHEMICAL AND PHYSICAL ASPECTS. Contains reprint.

Box: 9 Folder: 43
Chemical Modification Of Arginine With 1, 2 - Cyclohexanedione, 1965

August. With Koji Toi, Edward Bynum and Elaine Norris. Published in THE JOURNAL OF BIOLOGICAL CHEMISTRY, Vol. 240, No. 8. Contains reprint.

Box: 9 Folder: 44
Synthesis and Structure Of Normal and Abnormal Hemoglobins, 1965

From the National Institute of Arthritis and Metabolic Disease. Contains typescript, draft and reprint.

Box: 9 Folder: 45
Genetic Regulation Of Peptide Synthesis In Hemoglobins, 1965

June. Published in THE JOURNAL OF CELLULAR PHYSIOLOGY, Vol. 67, No. 3. Contains reprint.

Box: 9 Folder: 46
Phenanthrenequinone As an Analytical Reagent For Arginine and Other Monosubstituted Guanidines, 1966

August. With Shigeki Yamada. Published in BIOCHIMICA ET BIOPHYSICA ACTA, Vol. 130. Contains reprint.

Box: 9 Folder: 47
Studies On the Chemical Modification Of Arginine, 1967

March 10. With Koji Toi, Edward Bynum and Elaine Norris. Published in THE JOURNAL OF BIOLOGICAL CHEMISTRY, Vol. 242, No. 5. Contains reprint.

Box: 9 Folder: 48
Protein - Protein Interaction Among Hemoglobin Subunits, 1967

March. With A. J. Gottlieb and E. Robinson. Published in ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, Vol. 118, No. 3. Contains reprint.

Box: 9 Folder: 49
Primary Structure Of Hopkins - I Haemoglobin, 1967

April. WIth A. J. Gottlieb and E. A. Robinson. Published in NATURE, Vol. 214, No. 5084. Contains reprint.

Box: 9 Folder: 50
Chain Models Of 6.6 S and 3.9 S Mouse Myeloma Immunoglobulin Molecules, 1968

November. With T. Seki and E. Appella. Published in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES. Contains reprint.

Box: 9 Folder: 51
Structure - Rate Hypothesis and the Toll Bridge Analogy, 1968

Contains offprint.

Box: 9 Folder: 52
Studies On the Quantitative Control Of Polypeptide Synthesis In Human Reticulocytes, 1968

With Haig H. Kazazian. Published in THE JOURNAL OF BIOLOGICAL CHEMISTRY, Vol. 243, No. 8. Contains reprint.

Box: 9 Folder: 53
Comparitive Structures Of A Immunoglobins, 1969

June 1 - 7. With E. Apella, T. Seki and E. A. Robinson. Presented at a Symposium on Developmental Aspects of Antibody Formation and Structure at the National Institute of Health in Maryland. Contains reprint.

Box: 9 Folder: 54
Introductory Speech For the Symposium On Metabolism Of Blood Pigment, 1960

September 4 - 10. Published in the Proceedings of the VIIIth International Congress of Hematology, held in Tokyo, Japan.

Box: 9 Folder: 55
Phenyldiimide, Hemoglobin, and Heinz Bodies, 1970

October. Published in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, Vol. 67, No. 2. Contains reprint.

Box: 9 Folder: 56
Moilar Extinction Coefficient Of Cyanmethemoglobin As Determined By Carbon Analysis, 1971

February. With W. M. Fogarty Jr. and W. C. Alford. Published in THE AMERICAN JOURNAL OF CLINICAL PATHOLOGY, Vol. 55, No. 2. Contains reprint.

Box: 9 Folder: 57
4 - Thialamine, a Strongly Basic Chemical Modification Of Cysteine, 1972

August 10. With Elizabeth A. Robinson. Published in THE JOURNAL OF BIOLOGICAL CHEMISTRY, Vol. 247, No. 15. Contains reprint.

Box: 9 Folder: 58
2 - Aminophenantromidazole, Flourescent Product Of the Reaction Of Phenanthrenequinone, 1972

August. With Shigeki Yamada. Published in ANALYTICAL BIOCHEMISTRY, Vol. 48, No. 2. Contains reprint.

Box: 9 Folder: 59
Methoanolysis Of the Pyrrolidone Of Amino - Terminal Pyroalutamic Acid In Model Peptides, 1972

August. Published in ANALYTICAL BIOCHEMISTRY, Vol. 48, No. 2. Contains reprint.

Box: 9 Folder: 60
Stoichiometry Of the Oxidation Of Arylhydrazines With Ferricyanide, 1973

June. With S. Mannen. Published in TETRAHEDRON, Vol. 29. Contains reprint.

Box: 9 Folder: 61
Delayed Removal Of N - Terminal Methionine From Nascent Global Chains In Sickle - Cell Anemia Reticulocytes, 1973

July. With Haruo Suzuki. Published in the PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, Vol. 70, No. 7. Contains reprint.

Box: 9 Folder: 62
Quantitative Differences Between N - Terminal Methionyl Nascent Globin Chains Of Human and Rabbit Reticulocyte, 1973

November. Published in NATURE NEW BIOLOGY, Vol. 246, No. 152. Contains reprint.

Box: 9 Folder: 63
Alkaline Condensation Of 9, 10 - Phenanthrenedione With N, N - Dialkyguandines, 1974

December. Published in THE JOURNAL OF HETEROCYCLIC CHEMISTRY, Vol. 11. Contains reprint and two requests for reprints.

Box: 9 Folder: 64
Absence Of Haemoglobin A In an Individual Simultaneously Heterozygous In the Genes For Hereditary.., 1974

With W. M. Fogarty Jr. and T. S. Vedvick. Published in THE BRITISH JOURNAL OF HAEMATOLOGY, Vol. 26. Contains reprint.

Box: 9 Folder: 65
Effect Of Ring Substitution On the Hemolytic Action Of Arylhdrazines [38904], 1974

With David W. Hollister, William M. Fogarty, Jr. and Shigeyasu Mannen. Published in PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE, Vol. 147. Contains reprint.

Box: 9 Folder: 66
Solubility Changes In Sickle Cell Hemoglobin As the Amino Groups are Carbamylated [38321], 1974

With T. S. Vedvick and H. M. Koenig. Published in the PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE, Vol. 147. Contains reprint.

Box: 9 Folder: 67
Mechanism Of Induction Of Hœmolytic Anaemia By Phenylhydrazine, 1975

August 21. Published in NATURE, Vol. 256, No. 5519. Contains reprint.

Box: 9 Folder: 68
Deoxhemoglobin S : Solubility Vs. Erythrocyte Sickling, 1975

With T. S. Vedvick and H. M. Koenig. Published in CLINICAL BIOCHEMISTRY, Vol. 8. Contains reprint.

Box: 9 Folder: 69
Induction Of Haemolytic Anaemia By Substituted Phenylhydrazines, 1975

With K. Hosokawa and K. Hirota. Published in THE BRITISH JOURNAL OF HAEMATOLOGY, Vol. 32, No. 99. Contains reprint.

Box: 9 Folder: 70
Reactions Of Phenyldiazene and Ring - Substituted Phenyldiazenes With Ferrihemoglobin, 1975

With Shigeyasu Mannen. Published in BIOCHIMICA ET BIOPHYSICA ACTA, Vol. 421. Contains reprint.

Box: 9 Folder: 71
Topics In Hematology, 1976

September. Published in Excerpta Medica International Congress Series, No. 415. Contains reprint.

Box: 9 Folder: 72
In Vitro Translation Of Globin: Effect Of Proteins Purified By Affinity Chromatography On Polyadenylate.., 1976

With Hiroichi Fukami. Published in BIOCHEMISTRY, Vol. 15, No. 3529. Contains reprint.

Box: 9 Folder: 73
Mechanism and Specifity Of the Phenanthrenequinone Test for Monosubstituted Guanidines, 1976

With Kazuhiro Hirota, Ichiro Kawasaki and Shigeki Yamada. Published in ANALYTICAL BIOCHEMISTRY, Vol. 76. Contains reprint.

Box: 9 Folder: 74
Partial Characterization Of the Hemoglobin From Hubb's Beaked Whale, 1976

With T. S. Vedvick. Published in COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY, Vol. 55B. Contains reprint.

Box: 9 Folder: 75
Liglands and Oxidants In Ferrihemochrome Formation and Oxidative Hemolysis, 1977

June. With Kazuhiro Hirota and Thomas Vedvick. Published in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, Vol. 74, No. 6. Contains reprint and typescript of adresses.

Box: 9 Folder: 76
Influence Of Ring Substitutes On the Binding Of Nitrosobenzene By Ferrohemoglobin, 1978

May. With Kazuhiro Hirota. Published in THE JOURNAL OF BIOCHEMISTRY, Vol. 253, No. 10. Contains reprint.

Box: 9 Folder: 77
Oxidative Degradation Of Haemoglobin By Nitrosobenzene In the Erythrocyte, 1978

With Kazuhiro Hirota and Thomas S. Vedvick. Published in THE BIOCHEMISTRY JOURNAL, Vol. 174. Contains reprint.

Box: 9 Folder: 78
Initiation Of Fetal Hemoglobin Biosynthesis, 1979

With Hitoshi Imanishi and Haruo Suzuki. Published in BIOCHIMICA ET BIOPHYSICA ACTA, Vol. 564. Contains reprint.

Box: 9 Folder: 79
Induction Of Anemia In Spelnectomized and Nonsplenectomized Rats, 1980

With Thomas S. Vedvick. Published in PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE, Vol. 163. Contains reprint.

Box: 9 Folder: 80
Further Studies On the Chemical Modification Of Arginine

Undated. Contains one page typescript.

Box: 9 Folder: 81
Genetic and Physical Factors In the Meterogeneity Of Hemoglobin

Undated. Contains reprint.

Box: 9 Folder: 82
Interpretation Of Data On Haemoglobin Heterogeneity

Undated. Contains reprint.

Box: 9 Folder: 83
Sensitive Test For Arginine and Other Guanido Compounds

Undated. Contains one page typescript.

MATERIALS RE: LINUS PAULING

Box: 10 Folder: 1
Announcements and broadsides of events with participation of Linus Pauling or dedicated to him, 1946 - 1994
Box: 10 Folder: 2
Newspaper and magazine articles about Pauling, 1946 - 1998