Russell Doolittle Biochemistry Laboratory Records, 1964-2016 (MSS 77)

Extent: 99.0 Linear feet (83 records cartons, 37 archives boxes, 16 oversize folders and 1 art bin item)

The records of Dr. Russell F. Doolittle's biochemistry laboratory at the University of California, San Diego include notebooks related to the first determination of the complete sequence of amino acids in the human fibrinogen molecule, paper files for the amino acid sequences contained in the protein sequence data bank called NEWAT, as well as other research, correspondence and Protein Society files.

Dr. Russell F. Doolittle, professor of biochemistry at the University of California, San Diego, headed a campus science laboratory that conducted research in the evolutionary and structural aspects of proteins. In 1979, Doolittle's laboratory successfully analyzed the structure of the amino acid sequence for the human fibrinogen molecule. During that study, ten to twenty postdoctoral, graduate and undergraduate researchers worked to pull apart and analyze the amino acid sequences in the alpha, beta and gamma chains of fibrinogen. Doolittle adapted a peptide synthesizing machine to break apart peptides and employed an amino acid analyzer to identify the sequences. The peptide synthesizer, which was the second peptide synthesizer ever constructed, was modeled on the prototype designed by Bruce Merrifield, then of Rockefeller University. Merrifield was later awarded the Nobel Prize for the design of the machine.

The UC San Diego machine was constructed in 1964 at the instigation of Martin Kamen, a member of the Chemistry faculty. Professor Kamen had seen Merrifield's machine and, on his return to San Diego, asked Arthur Robinson, a graduate student in the Chemistry Department, to oversee construction of the machine. Robinson journeyed back to New York to examine Merrifield's machine more closely and then, after returning to San Diego, began constructing the Doolittle Laboratory's machine. After a period of time, the machine was converted into a peptide sequencer. Instead of building up peptides one amino acid at a time, it would take them apart one amino acid at a time. In 1979, the machine was used to make the first determination of the complete amino acid sequence for the human fibrinogen molecule, which is composed of 2,934 amino acids.

Doolittle also constructed a protein sequence data bank called NEWAT. Sequences identified in the published literature were entered into an electronic database and new sequences were searched against known sequences. In 1983, Doolittle used the data bank to link separate research efforts at the Center for Blood Research in Boston and the National Cancer Institute in Washington, D.C. He related a known cancer gene to a gene with a known function in human cells.

Doolittle, who was born in 1931 in New Haven, Connecticut, received his doctorate in biochemistry from Harvard Medical School in 1961. He joined the UC San Diego Department of Biology as a researcher in 1964, and then the Department of Chemistry and Biochemistry as assistant professor in 1965. Throughout his tenure at UC San Diego he also held positions as professor for the Division of Biological Sciences, Section of Molecular Biology, and the Center for Molecular Genetics. He served as chair of the Chemistry Department from 1981 to 1984, as chair of the Academic Senate, and on the editorial board for Protein Science. He was a member of the National Academy of Sciences and the American Academy of Arts and Sciences, a Guggenheim Fellow, and a recipient of the Paul Ehrlich Prize and the John J. Carty Award for the Advancement of Science. Doolittle died in 2019 in La Jolla, California.

The Russell Doolittle Biochemistry Laboratory Records document the activities of a UC San Diego science laboratory engaged in research on the structure and evolution of proteins.

Accession Processed in 1997

Arranged in three series: 1) NEWAT, 2) LABORATORY NOTEBOOKS and 3) AMINO ACID SEQUENCER.

Accession Processed in 2006

Arranged in eight series: 4) CORRESPONDENCE, 5) LAB NOTEBOOKS, 6) RESEARCH, 7) NEWAT, 8) PROTEIN SOCIETY, 9) PUBLICATIONS, 10) GRANTS/BUDGETS and 11) TEACHING FILES.

Accession Processed in 2021

Arranged in two series: 12) CORRESPONDENCE, and 13) RESEARCH AND WRITINGS.

Container List

Accession Processed in 1997

NEWAT

Scope and Content of Series

Series 1) NEWAT: Journal articles, printouts and summary data reports for individual amino acid sequences that were entered into the protein sequence data bank. The series begins with a list that relates the folder title acronym to the name and the journal citation for each amino acid sequence. The materials are arranged alphabetically by acronym.

Box 1 Folder 1
Index to acronyms
Box 1 Folder 2
2GPH to ATHT
Box 2
ATPC1, -2, -3, -4, -5 to CHEY
Box 3
CHEZ to DEGC
Box 4
DGI7 to FBCH1
Box 5
F7BO to GYPD 1 and 2
Box 6
HICT to IF2B
Box 7
IF3E to LYMH
Box 8
M3RD to ORDN
Box 9
OREC to PSPB
Box 10
PSI1 to PYRP
Box 11
SIRV to TFWS
Box 12
TFT4 to VP2S
Box 13
VPIM to ZUKE

LABORATORY NOTEBOOKS

Scope and Content of Series

Series 2) LABORATORY NOTEBOOKS: Notebooks by individual postdoctoral, graduate and undergraduate researchers who worked on the project. Also included are notebooks that contain amino acid analysis charts and high performance liquid chromatography charts. The notebooks are arranged by name of researcher, subproject and type of chart as follows: 2A) Watt, Ken; 2B) Bouma, H.; 2C) Takagi, T.; 2D) Miscellaneous Researchers; 2E) Electric Birefringence; 2F) Peptide Synthesis; 2G) Analysis Charts; and 2H) High Performance Liquid Chromatography Charts.

Watt, Ken

Box 14 Folder 1-2
Book 1 - Beta Chain CNBr / Lysozyme HSer Coupling, 1976 October 1 - 1978 November 30
Box 14 Folder 3-11
Books 2-6 - H Beta 0 CN I-II, CN V-VII, 1976 October 1 - 1978 September 30
Box 14 Folder 12
Book 7 - Sequence H Beta CN VId, 1976 December 2 - 1978 March 31
Box 14 Folder 13
Book 8 - H Beta CN II, Glu Cleavage, 1977 January 1 - 1977 November 30
Box 14 Folder 14
Book 9 - H Beta CN IV, 1977 January 1 - December 31
Box 15 Folder 1
Book 10 - H Beta CN III, 1977 January 1 - August 31
Box 15 Folder 2-3
Book 11 - Citraconylation, Tryptic Digestion of Human 0 Beta Chain, 1977 March 1 - 1977 June 1
Box 15 Folder 4
Book 12 - H Beta CN Vb, 1977 March 1 - August 31
Box 15 Folder 5
Book 13 - CN VI C-2, CN VIf, H Beta CVI VI C-3, CN VI b-1, CN VIC-4, CN VI C-1, CN VIa, 1977 March 1 - May 31
Box 15 Folder 6
Book 14 - H Beta CN IVb, 1977 March 1 - July 31
Box 15 Folder 7-8
Book 15 - H Beta CN IIIa from Re-chromatog, 1977 May 1 - October 31
Box 15 Folder 9
Book 16 - H Beta CN IIIb, CN IVa, 1977 July 1 - August 31
Box 15 Folder 10-11
Book 17 - H Beta CN V TR, 1977 July 1 - December 31
Box 15 Folder 12
Book 18 - H Beta CN IV TR, Glu, 1977 July 1 - September 30
Box 15 Folder 13-14
Book 19 - H Beta CN IVe, 1977 July 1 - October 31
Box 15 Folder 15-16
Book 20 - H Beta CN III CT and TR, 1977 July 1 - August 31
Box 15 Folder 17
Book 21 - H Alpha 6d Ch, TR, 1977 August 1 - 1979 June 30
Box 15 Folder 18
Book 22 - H Beta CN V Glu-, 1977 October 1 - 1978 January 31
Box 16 Folder 1
Book 23 - H Beta CN III TR, 1977 October 1-31
Box 16 Folder 2-3
Book 24 - H Beta CT, 1977 November 1 - 1978 January 31
Box 16 Folder 4
Book 25 - H Beta CN Ne CT, and Sequence, 1977 December 1-31
Box 16 Folder 5-7
Book 26 - H Beta Glu, 1977 December 1 - 1978 February 28
Box 16 Folder 8-9
Book 27 - H Beta CN II Glu EDC Sequence, 1978 January 1-31
Box 16 Folder 10-11
Book 28 - Alpha Chain CNI Sequence Summary, H Beta Glu Sequence, 1978 February 1 - May 31
Box 16 Folder 12
Book 29 - H Beta CNI GEE DITC Bends, 1978 September 1-30
Box 16 Folder 13-14
Book 30 - H Alpha CN1 PL1 SP1 Ch, 1978 October 1 - 1979 March 31
Box 16 Folder 15-16
Book 31 - H Alpha CNI SPI Ch 2nd, 1978 November 1 - 1979 February 28
Box 16 Folder 17
Book 32 - PLI SP2 Ch to SGSFRP...E, ENI SP Pool 2, 1979 January 1 - February 28
Box 16 Folder 18
Book 33 - H Alpha CN1 SP2 Ch SP2dnp to Ng, 1979 February 1 - March 31
Box 16 Folder 19
Book 34 - H Alpha CN1 SP1 Ch, 1979 February 1 - 1979 March 31
Box 16 Folder 20
Book 35 - H Alpha Chain, 1979 April 1 - June 30
Box 17 Folder 1-2
Book 35, cont. - H Alpha Chain, 1979 April 1 - June 30
Box 17 Folder 3-4
Book 36 - H Alpha, Glu Digest Continuation of 1/78 Prep (70mg), 1979 May 1-31
Box 17 Folder 5-6
Book 37 - H Alpha Glu (sequence) 71mg prep, 1979 May 1 - June 30
Box 17 Folder 7-10
Book 38 - H Alpha - Subscript 2 - SP 72 6 mg G50, 1979 June 1-30
Box 17 Folder 11
Book 39 - Ch H Alpha CNI PLII, 1978 March 1 - July 31
Box 17 Folder 12-14
Book 40 - H Alpha - Subscript 2 - CNI Ch-, 1978 March 1-31
Box 17 Folder 15-17
Book 41 - H Alpha CNI Ch Sequence, 1978 April 1 - August 31
Box 17 Folder 18
Book 42 - H Alpha, CNI Tryptophan, 1978 April 1 - June 30
Box 17 Folder 19-20
Book 43 - H Beta Chain Trypson, 1978 April 1 - May 31
Box 17 Folder 21
Book 44 - Frag. D, CN III C, TR, 1978 May 1 - July 31
Box 18 Folder 1-3
Book 45 - H Beta (CN Br), HD Beta Tryptic, 1978 May 1 - September 30
Box 18 Folder 4
Book 46 - H Alpha CNI PLI Ch, 1978 June 1-30
Box 18 Folder 5
Book 47 - H Alpha CNI PLI Ch (EDC), 1978 April 1 - August 31
Box 18 Folder 6
Book 48 - H Alpha CNI PL2, Ch2, Ch1, 1978 July 1-31
Box 18 Folder 7
Book 49 - II H Alpha CNI Tryptophan, 1978 August 1-31
Box 18 Folder 8-10
Book 50 - H Alpha CN1 PL1 Ch 2hrs, 37 degrees 1/50 ration, partially GEE, 1978 August 1 - 1979 January 31

Bouma, H

Box 18 Folder 11-16
Books 1-2. Human Fibrinogen; Gamma Chain; Citraconyl - Trypsin, G-50; Peaks II-VIII, 1975 September 1 - 1976 July 31
Box 18 Folder 17
Book 3 - Miscellaneous: Anti-human Fibrinogen; 4, 4'-diaminobenzil; TATG synthesis, 1975 September 1 - 1976 September 30
Box 18 Folder 18
Book 4 - Human Fibrinogen; Gamma Chain; Citraconyl - Trypsin, G-50; Peaks II, III, VIII, 1976 January 1 - June 30
Box 19 Folder 1-2
Book 4, cont. - Human Fibrinogen; Gamma Chain; Citraconyl - Trypsin, G-50; Peaks II, III, VIII, 1976 January 1 - June 30
Box 19 Folder 3
Book 5 - Human Fibrinogen; Gamma Chain; Citraconyl-Trypsin, G-50; Peaks V and VI, 1976 January 1 - August 31
Box 19 Folder 4-5
Book 6 - Human Fibrinogen; Gamma Chain; Citraconyl-Trypsin; G-50; Peak II; Deblocked, Trypsin, G-25, 1976 January 1 - March 31
Box 19 Folder 6-7
Book 7 - Human Fibrinogen; Gamma Chain; Succinylated, Aminoethylated; Trypsin, G-25; Peaks 1, 4, 5, and 6, 1976 October 1 - 1977 January 31
Box 19 Folder 8-9
Book 8 - Human Fibrinogen; Gamma Chain; Succinylated, 14 C-aminoethylated; Trypsin, G-25; Peaks 1, 4, 5, and 6 (synthesis: 14 C-bromoethylamine), 1976 December 1 - 1977 August 31
Box 19 Folder 10-11
Book 9 - Fibrinogen Sulfitolysis; S-sulfo Human Fibrinogen Separations; Gamma Chain Modifications (aminoethylation, cyclohexanedione, tryptic cleavages), 1976 August 1 - November 30
Box 19 Folder 12-13
Book 10 - HG, CT2 (HG, CT2, AT3) (HG, CT2, AT4 and AT5); HG CT5; HG CT6; HG CT7, 1977 March 1 - April 30
Box 19 Folder 14-15
Book 11 - HG, CT 3B; TRa-2; TRb-2, 1977 April 1 - June 30
Box 19 Folder 16-17
Book 12 - Plasmin - 0ib DE-52; CNBr-G-100 Columns; TR-G-25 Columns, 1977 August 1 - 1978 January 31
Box 19 Folder 18
Book 13 - HF, PLD, CN III B; HF, PLD, CN III C, 1977 December 1-31
Box 20 Folder 1
Book 13, cont. - HF, PLD, CN III B; HF, PLD, CN III C, 1977 December 1-31
Box 20 Folder 2
Book 14 - HF, PLD, CN II; HF, PLD, CN III, 1978 February 1 - May 31
Box 20 Folder 3-4
Book 15 - G - 37 1/2; HF, PLD, CN I, TRA-2; ... A-3; ... A-4, 1977 December 1 - 1978 January 31
Box 20 Folder 5-8
Book 16 - HF, PLD, CN I, TRA; HF, PLD, CN I, TRB, 1977 December 1 - 1978 March 31
Box 20 Folder 9-10
Book 17 - Frag D; CN I, TR pH 7.0; Peak B-D, 1978 March 1 - June 30
Box 20 Folder 11
Book 18 - Tryptic-digest; Human Fibrinogen; Gamma Chain, 1978 June 1 - July 31
Box 20 Folder 12
Book 19 - Fragment D; CN I, TRA; pH 7.0 Trypsin; G-25, 1978 April 1 - July 31

Takagi, T

Box 20 Folder 13-14
Book 1 - H Gamma CT Pools I, II, III, DNS; CT I, II, III TATG (electrophoresis, CNBr), 1973 November 1 - 1974 July 31
Box 20 Folder 15-17
Book 2 - H Gamma CT IV - VIII (gel filtration, paper el., ion exchange - Aminex A5), 1973 November 1 - 1974 July 31
Box 20 Folder 18
Book 3 - H Gamma CNB R and A; Trypsin I - IV (gel filtration, paper el.), 1974 May 1 - August 31
Box 21 Folder 1
Book 3, cont. - H Gamma CNB R and A; Trypsin I - IV (gel filtration, paper el.), 1974 May 1 - August 31
Box 21 Folder 2
Book 4 - H Gamma chain; AAA 24, 48,72 hr.; Tryptophan Det with Methane Sulfonic Acid; H Gamma CNI AAA 3/75, 1973 July 1 - December 31
Box 21 Folder 3-4
Book 5 - H Gamma CNI Chymotrypsin Gel Filtration G-25 Paper El, 1974 September 1 - November 30
Box 21 Folder 5-8
Books 6-7 - H Gamma CNI Pepsin Gel Filtration G-25 Paper El, 1974 October 1 - November 30
Box 21 Folder 9
Book 8 - Gamma CN III, IV, V, 1973 September 1 - 1974 October 31
Box 21 Folder 10-13
Book 9, 1973 November
Box 21 Folder 14
Book 10 - Collagenase Digestion of H0, 1974 March - April
Box 21 Folder 15-18
Book 11 - Plasmin Digestion, 1974 April - May
Box 21 Folder 19
Book 12 - HD, CNBr G-100 Purification, Enzyme Digestions, 1975 January - March
Box 22 Folder 1
Book 12, cont. - HD, CNBr G-100 Purification, Enzyme Digestions, 1975 January - March
Box 22 Folder 2
Book 13 - Separation of D and E on Biogel A 1.5 M, 4 m Guanidine, 1974 February - July
Box 22 Folder 3
Book 14 - HDII: Separation, R and A, Purification, Enzyme Digestion, 1974 August - December
Box 22 Folder 4-5
Book 15 - HE R and A -- G-25, Paper El, 1974 July
Box 22 Folder 6-7
Book 16 - Gel Filtration of D and E, HE CNBr -- G-50, Paper El of Peptides, 1974 May - July
Box 22 Folder 8-9
Book 17 - HE CNBr (S-S) in E, Purification of CNBr Peptides, 1974 August - 1975 January
Box 22 Folder 10-11
Book 18 - FIIB-2, FIIB-3, FIIB-4, FIIB-5, D-D3, 1974 February - 1975 February
Box 22 Folder 12-13
Book 19 - CNBr Digestion of H Fibrin, 1974 October - 1975 February
Box 22 Folder 14-15
Book 20 - TATG of H Fragments D, E, 1974 February
Box 22 Folder 16
Book 21 - H0 CNBR, H Gamma CNBr, 1974 February - May
Box 22 Folder 17
Book 22 - H 14C GEE Labelled Gamma Chain, Fragments from Plasmin Digestion of H GEE Fibrins, 1974 February - May
Box 22 Folder 18
Book 23 - TATG of H Fragment D, E (see envelope), 1974 May - August
Box 22 Folder 19
Book 24 - Human Gamma G-50, Purification of Pools 4.5 and 6, Enzyme Digestion of Cyanogen Bromide Pools, 1974 December - 1975 February
Box 23 Folder 1-2
Book 25 - Beta chain CNBr, G-100 10% HAc Purfication, 1974 August - 1975 December
Box 23 Folder 3-4
Book 26 - Separation of H Gamma, Beta Chains CM52, Beta Chain CNBr Peptides AAA, 1974 March
Box 23 Folder 5
Book 27 - Bov Gamma CNBr A,B,C, AAA (Bovine)
Box 23 Folder 6
Book 28 - Oxidized Bov Gamma Chain and Its CNBr Fragments, Separation Biogel 1.5 Purification by Paper El, 1974 January - February
Box 23 Folder 7
Book 29 - H Fragment A from Plasmin, digest 10', 90', 15 hrs, Enzyme Digestion, 1972 May
Box 23 Folder 8-11
Book A - HF XIII: H "X" Trypsin ( Thermolysin, Chymotrypsin ); PCAase, Pronase, CPase; HX for TATG; P - Ser; Pepsin; Platelet "X", 1972 December 1 - 1973 October 31
Box 23 Folder 12-13
Book B - Preparation of BF XIII, HF XIII (Biogel A1.5, Platelet F XIII, DE-52 SOS gels); Activation of F XIII; Trypsin Dig. of 14C GEE F XIII; Sulfitolysis of F XIII *; Separation of A and B Chains of F XIII *, 1972 September 1 - 1973 September 30
Box 23 Folder 14-16
Book C - TATG: H, B FXIII, FXIII *; ClG; Platelet F XIII *; Seattle F XIII *, 1972 November 1 - 1973 November 31
Box 23 Folder 17-18
Book D - Bov P "X" F XIII; Preparation; Trypsin Digestion; Chymotrypsin; PCA to Th; Trypsin to Th, 1972 October 1 - 1973 October 31
Box 23 Folder 19
Book E - Bov Gamma ( plasmin, trypsin SDS gels ); GEE B Gamma - Plasmin; B 0 plasmin, 1972 August 1 - 1973 March 31

Miscellaneous researchers

Box 24 Folder 1-2
Friezner, S. - H Gamma CNI Trypsin, 1975 June

Lin, Y

Box 24 Folder 3
H 14C GEE Alpha Electrophoresis; T-boc Reactions T-boc-EA, 1971 February 1 - May 31
Box 24 Folder 4-5
Synthesis of HFpA; A-D-S-G-E-G-D-F-A-A-0; Preparation of Bovine Insulin; A and B Chains, 1971 February 1 - 1974 May 31
Box 24 Folder 6
Maffly, B. and Goldbaum, D. - HPLC, 1976 April - 1978 January

Electric Birefringence

Cottrell, B

Box 24 Folder 7-8
Book 1, 1973
Box 24 Folder 9-11
Book 2 - Photographs, computer programs and basic user manual, 1973 - 1974
Box 24 Folder 12-17
Books 3-5, 1974-1975
Box 24 Folder 18
Computer Graphs B/C
Box 25 Folder 1
Computation Book, 1973 October 22
Box 25 Folder 2-3
Computer Graphs, Upsilon, Theta
Box 25 Folder 4-5
Data Output. Elbra
Box 25 Folder 6-7
Log Book
Box 25 Folder 8-9
Troll, M. - System logic of the laser birefringence machine, reprints, technical information, equipment specifications

Analysis Charts

Box 27 Folder 4
2 VB Sequence
Box 27 Folder 5
AAA of Gamma Chains Trp Det
Box 27 Folder 6-8
Bead Data SP Digest of PLI
Box 27 Folder 9
Bov Gamma Chains, 1973
Box 27 Folder 10
Bov Gamma Chains II
Box 27 Folder 11
CN I, PL I, SP I, PL II, Tryptic Data, Chymo, SP Peptides, 1979
Box 27 Folder 12
CN - V B, C, and D - B Gamma CN from pH2, SC - pH 9.5, CN5B - pH 9.5, SD - pH 4.5
Box 27 Folder 13
CNBr, Cyanogen Bremide G-75 Runs
Box 27 Folder 14-15
Cys from PL2, SP PLI Parp #6, SP Digest CNI #3, SP Digest CNI #4
Box 27 Folder 16
D1 Binder D1 Non Binder 12/80 R and A Trypsin
Box 28 Folder 1
D2 Alpha - Trypsin
Box 28 Folder 2
D2 Rho Glass Beads
Box 28 Folder 3-4
H Alpha 2, CNI, TFA, CN IB, Trypsin
Box 28 Folder 5-6
H2 CN I PL I Se #2, S rho I TR - G-25
Box 28 Folder 7
H Alpha CNI CNBr = 70% TFA, H0CNI Pl I Glu, Pl 2 Glu
Box 28 Folder 8
H and CNI PL 3
Box 28 Folder 9-10
H Alpha 2, 1977
Box 28 Folder 11
H Alpha CN, 1976
Box 28 Folder 12-14
H Alpha CN III, 1976 - 1978
Box 28 Folder 15-16
H Alpha CN IV, 1975
Box 28 Folder 17
H Alpha CN4A
Box 28 Folder 18
H Alpha CN IV B
Box 29 Folder 1
H Alpha CN31
Box 29 Folder 2
H Alpha CN5B
Box 29 Folder 3
H Gamma Chain CN IV, 1975
Box 29 Folder 4
H Alpha CN CN-VII, 1977
Box 29 Folder 5
H Gamma Chain CN V-VII, 1977
Box 29 Folder 6
HD R and A BC 1980 D1 Gamma D3 Gamma Trypsin
Box 29 Folder 7-9
H Gamma Chain, 1971-1972
Box 29 Folder 10
Gamma Chains Preps CN III, CNIV
Box 29 Folder 11
HXLF CEE 7177 CN I Tal 23
Box 29 Folder 12
Machine H Alpha CN III "G7B", 1976
Box 29 Folder 13
Mellitin Sequence Run, 1980 July 18
Box 29 Folder 14
Sequence Guide , 1969-1970
Box 29 Folder 15
Sequenator log sheet
Box 30 Folder 1-2
SP Digest #4 PLI, TR Digest Over G.50
Box 30 Folder 3
SP Digest CNI #6, SP Digest CNI #9 (8/79), SP Digest CNI #11 (4/79)
Box 30 Folder 4
SP of PLI #3, SP of PLI #5, 1978 November 15
Box 30 Folder 5
Trypsin Digest
Box 30 Folder 6-15
Untitled

High Performance Liquid Chromatography Charts

Box 31 Folder 1-3
Untitled
Box 31 Folder 4
Acylase, N-Ac-Ab-C-Sar
Box 31 Folder 5
CMC
Box 31 Folder 6
Electrofocusing
Box 31 Folder 7
Funatsu Peptide
Box 31 Folder 8
HPLC Anion Exchange
Box 32 Folder 1
HPLC DMG PTH STDS
Box 32 Folder 2
HPLC JD
Box 32 Folder 3
HPLC Reverse phase, 1976 March - April

Peptide Synthesis

Box 25 Folder 10
BM Biochemica - Vol. 2 Number 3, 1985
Box 25 Folder 11-12
Books 9-10

Computation Notebooks

Box 25 Folder 13-18
Notebooks 1-6
Box 26 Folder 1-6
Notebooks 7-12
Box 26 Folder 7
Deoxynucleotide Synthesis, Phosphonylations, Monomer Synthesis, Dimer Synthesis
Box 26 Folder 8
DNA Sequencing 3:728-3D, 1985
Box 26 Folder 9
D.T. Peptide Synthesis
Box 26 Folder 10
Evans, Barbara - Untitled notebook
Box 26 Folder 11
Gel Sequencing
Box 26 Folder 12
Helices
Box 26 Folder 13
Lab Reports

Lamprey Transferrin

Evans, Barbara

Box 26 Folder 14-15
Untitled, 1983
Box 26 Folder 16
DNA Sequencing 463-1B, 1985 - 1986
Box 26 Folder 17
Plasmid Preps, 1984
Box 26 Folder 18
Sequence 1 Molecular Biology, 1984 - 1985
Box 26 Folder 19
Sequencing 2: 613-3B, 463-1B, 1985
Box 26 Folder 20
Nucleotide Synthesis - Oligonucleotide Probes, 1982
Box 26 Folder 21
Peptide Synthesis - James Kobut/R. Doolittle
Box 27 Folder 1-2
Pontes, Manuel
Box 27 Folder 3
RD and MTNICB0

AMINO ACID SEQUENCER

Scope and Content of Series

Series 3) AMINO ACID SEQUENCER: This is the machine adapted by laboratory staff to pull apart amino acids.

Oversize AB-00-01
Sequencer

Accession Processed in 2006

CORRESPONDENCE

Scope and Content of Series

Series 4) CORRESPONDENCE: Arranged in three subseries: A) General, B) Incoming Email and C) Outgoing Email. The General Correspondence dates from 1964 to 1998 and includes correspondence from researchers and research institutions. The Incoming Email dates from 1988 to 1997. The Outgoing Email dates from 1989 to 1997.

General

Box 33 Folder 1
Canadian Institute for Advanced Research correspondence
Box 33 Folder 2
Correspondence (Fitch, Hampton, Laursen and Mawe), 1969 - 1970
Box 33 Folder 3
Correspondence with Dr. David Waxman, 1981
Box 33 Folder 4
Correspondence with Dr. Hawiger, 1980
Box 33 Folder 5
Correspondence with Dr. Walter
Box 33 Folder 6-19
1964-1977
Box 34 Folder 1-13
1977-1983
Box 35 Folder 1-11
1984-1987
Box 36 Folder 1-13
1987-1991
Box 37 Folder 1-9
1991-1994
Box 38 Folder 1-10
1995-1998
Box 39 Folder 1-8
1999-2003
Box 39 Folder 9
Ivan Rayment (collaboration)
Box 39 Folder 10
Letters from Russell F. Doolittle
Box 39 Folder 11
Old correspondence
Box 39 Folder 12
Patent Application, 1981
Box 39 Folder 13
Protein Folding Discussion Group, 1991
Box 39 Folder 14
Russell F. Doolittle mail and general instructions
Box 39 Folder 15
Sabbatical correspondence
Box 39 Folder 16
"Synthetic Peptide Antipolymerants of Fibrin" patent, March, 1982
Box 39 Folder 17
Uppsala University - Bioinformatics
Box 39 Folder 18
Virgil Woods' HIV Project: Detection and Characterization of Human Germline Incorporation of HIV-1
Box 39 Folder 19
Wei Duan's Thesis Exam

Incoming Email

Box 40 Folder 1-19
1988 January - 1993 April
Box 41 Folder 1-20
1993 May - 1995 January
Box 42 Folder 1-18
1995 February - 1996 May
Box 43 Folder 1-15
1996 June - 1997 August
Box 44 Folder 1-3
1997 September - November

Outgoing Email

Box 44 Folder 4
Human Genome Project newsletters, December, 1989-1990
Box 44 Folder 5-24
1985-1996
Box 45 Folder 1-8
1996 April - 1997 December

LABORATORY NOTEBOOKS

Scope and Content of Series

Series 5) LABORATORY NOTEBOOKS: Arranged in two subseries: A) By Researcher and B) By Subject. The By Researcher subseries contains research notes by Doolittle's assistants and are arranged alphabetically. The By Subject subseries is arranged alphabetically by the topic being researched, for example, Peptide Synthesis, Biochemistry and Molecular Genetics.

By Researcher

Box 46 Folder 1
Abanes, De Mello, Angelica - Bio Rotation - FReP, 1996 September 23 - November 1
Box 46 Folder 2
Aldaz, Hector, 1992 July 1 - September 1
Box 46 Folder 3
Bouma, Bud - Daily Log, 1975 September 15 - December
Box 46 Folder 4
Bystroff, Chris - Doolittle Lab summer rotations, 1983 July - September

Cairns, Jim

Box 46 Folder 5
Book 1. Clotting Experiments - Peptide Purification, 1993 August 3 - November 30
Box 46 Folder 6
Book 2. Project PGPRV-Reagent Preparation, 1993 - 1994
Box 47 Folder 1
Book 3.The Continuing Saga of the Disulfide Ring Peptide (796), 1993 December 2 - 1994 June 22
Box 47 Folder 2
Book 4. Fragment E. Digestion/Disulfides, 1994 May 18 - 1995 January 11
Box 47 Folder 3
Book 5. Disulfide Ring Peptide, 1994 June 22 - September 27

Chen, R

Box 47 Folder 4-5
Book 1: Chromatography of S-SO3 chains of BOV Phi F.XLF G-200 (6M urea) CM52, 1968 December - 1970 February
Box 47 Folder 6
Book 2: Rabbit Light Chain Enzyme digestions and chromatography S-Sulfo Phi Chromatography and AAA, 1968
Box 47 Folder 7
Book 3: C14-Gee-gamma Bovine AAA, 1969 June - 1971 August
Box 47 Folder 8
Book 4: B gamma C-14 GEE gamma Enzyme digestions Chromatograms Electrophoresis, 1969 June - 1970 December
Box 47 Folder 9
Book 5: Bov crosslinking expts. Amino Acids Analysis, 1969 January - 1970 February
Box 47 Folder 10
Book 6: Bov gamma-gamma TypeI trypsin Chromatography CM 52 G-100, 1969 July - 1970 July
Box 47 Folder 11
Book 7: AAA of 14C HgammaGee peptides from chromatography & el. 14C Halpha peptides from chromatography & el., 1970
Box 47 Folder 12
Book 8: Human 14C GEE fibrin CM52 Trypsin digestion of H "gamma" G-25 electrophoresis, 1969 December - 1970 July
Box 47 Folder 13
Book 9: HXLF GEE CM52 H&B XLphi Oklahoma F on CM52, 1970
Box 47 Folder 14
Book 10: Paper el. of: 14C Hgamma Th exp. mix control mis tryptic bovine gamma Oklahoma Pool 5 and bt glu-ala, 1970
Box 47 Folder 15
Book 11: Crosslinking experiments EDMANS, 1969 December - 1970 December
Box 47 Folder 16
Book 12: Uvicon Scans of various Sephadex Columns Data from scintillation counters, 1970
Box 48 Folder 1-3
Cho, Glen - Preparation of phi and metal derivatives, 1995 - 1996
Box 48 Folder 4
Clason, G.W., and M.E. Riley - Enzymology, 1969 - 1970
Box 48 Folder 5
Clinton, Gail - Rotator, Phosphorylated Serine in Fibrinogen, 1969

Cottrell, B.

Box 48 Folder 6
1973 February - 1974 December
Box 48 Folder 7
Hgamma CN3, Hgamma CNBC, Hgamma SC digest, 1980 December
Box 48 Folder 8
1980 February - 1983 January
Box 48 Folder 9
Book 1. Project DNA Sequencing, 1984 October 29 - November 29
Box 48 Folder 10
Evans, Barbara R. - Lamprey Molecular Biology: Northerns and Southerns, 1986 September - October

Everse, Stephen

Crystal Book

Box 48 Folder 11-14
Books 1-4, 1990 - 1994
Box 49 Folder 1-3
Books 5-7, 1994 - 1997
Box 49 Folder 4-6
Project 0 - Books 2-4, 1990 - 1991
Box 49 Folder 7-15
Project H0 - Books 5-13, 1991 - 1998
Box 49 Folder 16
Book 1. Rotation, 1990 January 5 - June 23
Box 50 Folder 1
Models, 1994 July 23 - 1998 July 11
Box 50 Folder 2
Fann, Wen-Pang

Feng, Da Fei

Box 50 Folder 3
1982 August - 1983 July
Box 50 Folder 4
1991 April - October
Box 50 Folder 5-6
CRB 233 UCSD, 1983 - 1985
Box 50 Folder 7-8
CRB 319 UCSD, 1985 - 1988
Box 50 Folder 9
Divergence, 1994 May - 1999 November
Box 50 Folder 10
Gas Project, 1988 July 7 - 1989 December
Box 50 Folder 11
Foreman/Freunal, Laura, 1999 November - 2000 May

Gray, Jeff

Box 50 Folder 12
Book 1. Project Research, 1986 April 15 - 1987 February 2
Box 50 Folder 13
Book 2. Project Research, 1987 February 5 - October 20
Box 50 Folder 14
Book 3. Project 7n/3 535-5D, 1987 October 26 - 1988 October 6
Box 50 Folder 15
Book 4. Project LMPP/LFerritin/AlphaChains, 1988 September - 1989 October 27
Box 50 Folder 16
Book 5. Project Lamprey Album, 1989 November 1 - 1990 October 5
Box 51 Folder 1
Peptide Solubility versus composition/size, 1986 August 13 - October 22
Box 51 Folder 2
Book 1. Retroviral Gag Proteins and Related Sequences, 1985 October 15 - 1986 January 14
Box 51 Folder 3
1990 October - 1991 March
Box 51 Folder 4-6
Handy, Jacob, 1997 - 1999
Box 51 Folder 7
Haschemeyer, A. Visiting Scientist - Fibrinogen, 1975 March

Healey, Carol

Box 51 Folder 8
Lipocalins/Fatty Acid Binding Proteins, 1993 April 9 - July 30
Box 51 Folder 9
Proteinase Inhibitors PSTI Basic, 1993 August 2
Box 51 Folder 10
Hiroyuki, Tom, 1992 winter
Box 51 Folder 11
Huang, Mai, 1998 - 2000
Box 51 Folder 12
Hucko, Judy, 1974 - 1975
Box 51 Folder 13
Jacque, Jean - ATA, 1980 - 1981
Box 51 Folder 14-15
Johnson, Aaron, 1989 - 1990
Box 51 Folder 16
Kamps, Mark - (Rotator), Rotation 1, 1981 October - November
Box 51 Folder 17
Keil, Andrea - DNA/RNA Extraction, 1982
Box 51 Folder 18
Kuei, Debbie and Jung Wang - Biochemistry , 1986 May 5 - September 30
Box 51 Folder 19
Lane, Ray, 1978 fall
Box 51 Folder 20
Lau, Francis - Master's lecture UC San Diego, 1970 April - September

Laudano, Andrew

Box 51 Folder 21
Book 1. Research, 1977 May 23 - September 13
Box 52 Folder 1-4
Books 2-5. Project Chemistry Research, 1977 September 14 - 1978 January 27
Box 52 Folder 5-7
Books 6-8. Biochemistry Research, 1979 January 29 - October 15
Box 52 Folder 8-9
Books 9-10. Project: Chemistry Research, 1979 May 15 - 1980 February 25
Box 52 Folder 10-12
Books 11-13. Biochemistry Research, 1980 February 25 - 1982 May 22
Box 52 Folder 13
Leong, Jane - Rotation, 1989 May 5 - June 7

Little, Elizabeth

Box 52 Folder 14
Book 1. Project Alpha-XL, 1993 October - 1994 February
Box 52 Folder 15
Book 1. Project Gels, 1993 November 29 - 1994 May 26
Box 52 Folder 16
Book 2. Project Alpha XL-2, 1994 February - June
Box 52 Folder 17
Maffly, Bob, 1977 - 1978
Box 52 Folder 18
Maher, David - Rotation, 1986 May
Box 52 Folder 19
Malden, Marx, 1991 December 26
Box 53 Folder 1
McAllister, Ryan - Percent identity/percent similarity data, 1999 summer
Box 53 Folder 2
Mross, George, 1975 - 1976
Box 53 Folder 3-4
Nagel, Glenn, #1-2, 1990 August 16 - June 4
Box 53 Folder 5
Nicewander, Penelope H., 1990 March 28 - July

Subject: Sequences

Box 53 Folder 6-12
Pan, Yang. Books 1-7, 1987 April 29 - 1992 October 16
Box 53 Folder 13
Pankratz, Dan - Rotator, 1997 - 1998
Box 53 Folder 14
Patterson, John - Sequencing Alpha Chain Fibrinogen, 1987 - 1988
Box 53 Folder 15
Picknar, Kathy - Book 1. Rotation, 1986 September 26 - December 17

Pontes, Manuel

Box 53 Folder 16
Oligonucleotide Chemistry, 1981 January 16 - 1983 February 23
Box 53 Folder 17
1981 April 16 - 1982 May 13
Box 54 Folder 1-5
Books 3-7. Molecular Biology, 1983 March 1 - 1986 May 28
Box 54 Folder 6
315 CRB, 1985 April 8 - December 2
Box 54 Folder 7
Project LMP 2, 1986 February 13 - July 19
Box 54 Folder 8
Rabbit Book - Immunology, 1974 - 1976
Box 54 Folder 9
Rhoades, Chris, 1993 June - July

Riley, Marcia

Box 54 Folder 10-11
Human Genetics Program, 1975 - 1979

Includes project cost book.

Box 54 Folder 12
Project E-Coli, 1983 March 1 - October 11
Box 54 Folder 13
Riley, M. and R. Doolittle, 1999 - 2000
Box 54 Folder 14-16
Rojas, Ana, 2000 - 2002
Box 54 Folder 17
Ryckewhert, 1983 - 1986

Shimizu, Akira

Box 55 Folder 1-3
Books 1-3. Photo Affinity Labeling, 1987 - 1989
Box 55 Folder 4
Peptide Synthesis, 1987 - 1989

Shipwash, Ed

Box 55 Folder 5
1994 August 2 - 1995 April 19
Box 55 Folder 6-8
Books 1-3, 1993 August 2 - 1994 May 16

Includes Project Alpha 2.

Box 55 Folder 9
Project Tissue Factor, 1993 August 2 - September 8
Box 55 Folder 10
Thompson, Katie. Russell Doolittle lab, 1988 April 5 - July
Box 55 Folder 11
Wetzel, Glenn, 1978 October 4 - December 16
Box 55 Folder 12
Wilson, Carolyn Anne. Project Brad Nolen, 1992 September 24 - December 11
Box 55 Folder 13
Wooding, Gretchen, 1970 June

Xu, Xun

Box 55 Folder 14
1990 February 22 - June 12
Box 55 Folder 15
Book 2, 1989 - 1990
Box 55 Folder 16
Project Sequence, 1985 - 1986

Yamazumi, Kensuke

Box 55 Folder 17
Book 1, 1990 - 1991
Box 56 Folder 1-3
Books 2-4. Photoaffinity labeling of frag. D1 with GPRK, 1991 - 1992
Box 56 Folder 4
Book 5. Photoaffinity labeling of frag. D1 with GPRC and GPRPK, 1991 - 1992
Box 56 Folder 5
Book 6. Photoaffinity labeling of frag. D1 with GHRPK and GHRK, 1992
Box 56 Folder 6
Book 7. Project GHRPx and GPRPnh2, 1992 May 26 - August 30

By Subject

Box 56 Folder 7
Phi CNI, PL1 TR AA Analyses, Peptides, GEE, A1 I - B. Cottrell, 1978 May - September

Auto Solid Phase Peptide Synthesis

Box 56 Folder 8-12
No. 1-5, 1983-1986
Box 57 Folder 1-9
No. 6-14, 1986-1991, undated
Box 57 Folder 10
Biology, Doolittle lab rotation - Rex Kerr, 1997 February - March
Box 57 Folder 11-14
Bohanus, V. 1-4, Beta Chain 2C 610, 1983-1985
Box 58 Folder 1-2
cDNA Library - Books #5-6, Yu, Caroline, 1986-1987

Includes gel pictures and graphs

Box 58 Folder 3
Circular Dichroism Machine Log, 1980 May - 1987 February
Box 58 Folder 4
Center for Molecular Genetics - Peptide Synthesizer 990, Igor Mochalkin
Box 58 Folder 5
CMG 213, GHRP-NH2 HPLC - Colin Aston, 2000 August 2
Box 58 Folder 6
Colony Hyb with Syn. Probes - Strong, D., 1983 March

Includes X-Rays

Box 58 Folder 7
Computer Aided Protein Evolution Studies - Woodbury, Neil, 1978 June
Box 58 Folder 8-9
Computer Guide and Maintenance - Woodbury, Neil, 1978 October 28, undated
Box 58 Folder 10-13
DNA Sequence L Alpha 713-3D - Yu, Caroline, 1985 - 1986

Includes gel pictures

Box 58 Folder 14
E1 E2 E3 - Bgamma, Trypsin
Box 58 Folder 15
Electric Birefringence, E.B. Summary, EDTA EXPT - R. Doolittle & B. Cottrell, 1974 summer
Box 58 Folder 16
Fibrinogen Preparations, Human, Lamprey, Mule, Opossum, Boxine, Rabbit, Rat, Mouse, Sheep. Includes graphs - Riley, Marcia, Russell Doolittle and Barbara Cottrell, et. al., 1972 September - 1976 December
Box 58 Folder 17
Fibrinopeptides-Part 1-Doolittle, Russell, et. al., 1968 - 1969

March-September. Mandrill, Chimpanzee, Collared Peccary, Mouflon, White Fallow Deer, Golden Jackal, South American Tapir. Including C. Glasgow. Contains graphs.

Box 59 Folder 1
Fibrinopeptides-Part 2-Doolittle, Russell, et. al., 1968 - 1969

March-September. Mandrill, Chimpanzee, Collared Peccary, Mouflon, White fallow Deer, Golden Jackal, South American Tapir. Including C. Glasgow. Contains graphs.

Box 59 Folder 2
Fragment E, R and A, E1E2E3, RD/SD/BC, 1978 September

Folder 1 of 2

Box 59 Folder 3
Gel Book #2- Riley, Marcia, 1987 - 1988

November-September. Includes gel photos.

Box 59 Folder 4-5
Genomic Library L Alpha B1, Books # 7-8, Yu, Caroline, 1987
Box 59 Folder 6
Hgamma, HgammaCN3+4, Trypsin, January, 1981
Box 59 Folder 7
H alpha CNI, GLU Beads, Pools 4-7, 4-7
Box 59 Folder 8
HPLC
Box 59 Folder 9
Human Cross- Link Fibrin - Doolittle, R. F. and Barbara Cottrell., 1978 - 1979

June-January. Includes graphs.

Box 59 Folder 10-11
Human Fibrinogen, Alpha Chain CNBr, 1975 - 1979

Cottrell, Barbara and Marcia Riley, et. al. and Human Fibrinogen Alpha Chain CNBr, 1976 July- Cottrell, Barbara. Includes graphs.

Box 59 Folder 12-13
Human Fibrinogen, Alpha Chain CN-5, Parts 1-2, Cottrell, Barbara, 1975 - 1976
Box 59 Folder 14
Human Fibrinogen, Alpha Chain CNBr GEE - Strong, Donna and Cottrell, Barbara, 1978 - 1979

October-June. Includes graphs.

Box 60 Folder 1
Human Fibrinogen, Alpha Chain, CNBr, PL - Strong, Donna, 1978

May-October. Includes graphs.

Box 60 Folder 2
Human Fibrinogen, Alpha Chain CNBr, Staph Protease - Cottrell, Barbara, 1978 - 1979

November-February. Includes graphs.

Box 60 Folder 3
Insert Gel Book - Riley, Marcia, 1985 - 1987

February-October. Includes gel pictures.

Box 60 Folder 4
JJR, 1982 June

Lab Notebook

Box 60 Folder 5-9
Cooke, Tracy, 1988

September-December

Box 60 Folder 10
Graham, David, 1987

Includes gel pictures

Box 60 Folder 11
Yu, Caroline, 1985 April 1
Box 60 Folder 12-13
Yu-then, Wang

Undated. Includes gel pictures.

Box 60 Folder 14-15
Lamprey Albumin, cDNA - Gray, Jeff, 1988 - 1990

December-May

Box 60 Folder 16
Lamprey Liver, c-DNA Screening, 1984 - 1986

Doolittle Lab

Box 60 Folder 17
LEECH Hirudin Prep. - Doolittle, R.F., et. al., 1977 - 1978

October-May. Includes graphs.

Box 61 Folder 1
Lobster and Fibrinogen, 1972 - 1973

B. Cottrell, K. Cassman

Box 61 Folder 2
Log-Manoj-George, 1987 summer
Box 61 Folder 3
'Matt' Rotation, 1993 February
Box 61 Folder 4
Molecular Genetics HPLC THUC TO
Box 61 Folder 5
More Programs for the PDP 11/04 - Woodbury, Neil, 1979 March
Box 61 Folder 6
New Juno, 1993 February 19
Box 61 Folder 7
Nicewander, Penelope N., 1990 January 8
Box 61 Folder 8
Notes on Computer 1 - Goyal, Manoj, 1987 April 24
Box 61 Folder 9-10
Oligonucleotide Synthesis, 1982 - 1983

Lab methods and summary

Box 61 Folder 11
PDP 11/04 Notes and Programs - Woodbury, Neil, 1978 - 1979
Box 61 Folder 12
Restriction Enzyme and Plasmid Inventories - Ellis, Carmen and Lisa Phanton, 1984 - 1986

October-December

Box 61 Folder 13
Rotations, 1996 fall
Box 61 Folder 14
Setting up Mini-Unix-Sixth Addition
Box 61 Folder 15
Smith, Mike, 1991 spring
Box 61 Folder 16
Smith, M.W.

Staph Clumping Factor

Box 61 Folder 17
Strong, D., 1980

February-May. Includes graphs and pictures.

Box 61 Folder 18
Fragment D, etc. - Part 1- Strong, D., et. al., 1981

March-June. Includes graphs.

Box 62 Folder 1
Fragment D, etc. - Part 2- Strong, D., et. al., 1981

March-June. Includes graphs.

Box 62 Folder 2
TATG Lob phi, 1980
Box 62 Folder 3
TATG Synthesis - Woods, Virgil and Russell Doolittle, George Moss, and John Sharp, 1973 - 1975

July-March

Box 62 Folder 4
Variant Human Fibrinogen ("D.MARR"), Thrombin-Inhibitors-Weinstein, Mark and Russell Doolittle, 1971 - 1972

May-May. Contains graphs.

Box 62 Folder 5
Vax Log - Zeus, Johnson, M., 1985 June 17
Box 62 Folder 6
Webb, Jenn, 2002 April 1
Box 62 Folder 7
Weigh Book, Doolittle, 1965 - 1973

Xun Xu

Box 62 Folder 8
cDNA Sequencing (1) LMPI, 1985 June 3-October 1
Box 62 Folder 9
M13 Sequence (3), 1986
Box 63 Folder 1
M.D., 1989
Box 63 Folder 2
Sequence 4, 1986
Box 63 Folder 3
Zeus Backup Log, mag-Tape Cleaning Log - Doolittle and Johnson, 1985 July 23

RESEARCH

Scope and Content of Series

Series 6) RESEARCH: Arranged in two subseries: A) Sequencing Research Correspondence and B) Files. The Sequencing Research Correspondence contains research information shared between Doolittle and other researchers or institutions. The Files subseries include research files and is arranged alphabetically.

Sequencing Research Correspondence

Box 64 Folder 1
Abad-Zapatero, Celerino - Purdue, 1985-1986
Box 64 Folder 2
Abelson, John - CalTech, 1985
Box 64 Folder 3
Alexander, Nick - UC San Diego, 1987
Box 64 Folder 4
Altieri, Dario - Scripps Research Institute, 1993
Box 64 Folder 5
Ames, Giovanna - UC Berkeley, 1986
Box 64 Folder 6
Amino acid analyzer, 1968-1971
Box 64 Folder 7
Anderson, David - CalTech, 1987
Box 64 Folder 8
Arai, Ken-ichi - DNAX, Palo Alto, 1984
Box 64 Folder 9
Armentrout, Ric - Syntro Corporation, San Diego, 1983
Box 64 Folder 10
Artavanis-Tsakonas, Spyros - Yale, 1990
Box 64 Folder 11
Atkinson, Mike - West Germany, 1983
Box 64 Folder 12
Attardi, Giuseppe - CalTech, 1984-1991
Box 64 Folder 13
Axel, Richard and Pascal Madaule - Columbia University, 1983
Box 64 Folder 14
Baker, Michael - UC San Diego, 1982-1985
Box 64 Folder 15
Baltimore, David - Rockefeller University, 1990
Box 64 Folder 16
Barklis, Eric - MIT, 1985
Box 64 Folder 17
Barondes, Sam and Doug Cooper - UC San Diego, 1984
Box 64 Folder 18
Beach, David - Cold Spring Harbor, 1987
Box 64 Folder 19
Bedinger, Patricia - Stanford, 1986
Box 64 Folder 20
Berg, Paul - Stanford, 1988
Box 64 Folder 21-22
Bernfield, Merton and Jurg Spring - Stanford, 1986-1988
Box 64 Folder 23
Bishop, Mike, 1982
Box 64 Folder 24
Bertrand, Kevin - UC Irvine, 1983
Box 64 Folder 25
Blackshear, Perry - Duke University, 1991
Box 64 Folder 26
Blood correspondence, 1966-1972
Box 64 Folder 27
Blumenthal, Kenneth - Ohio, 1982
Box 64 Folder 28
Bohlen, Peter - Salk Institute, 1983
Box 64 Folder 29
Bollengier, F. - Belgium, 1986
Box 64 Folder 30
Boorstein, Will - CalTech, 1992
Box 64 Folder 31
Bostian, Keith - Brown University, 1985
Box 64 Folder 32
Bouchard, Robert - UC San Diego, 1985
Box 64 Folder 33
Bouchard, Robert - College of Wooster, Ohio, 1987
Box 64 Folder 34
Bourgeois, Suzanne - Salk Institute, 1990
Box 64 Folder 35
Boyd, Alan - University of Leicester, 1984
Box 64 Folder 36
Bradshaw, Ralph - UC Irvine, 1984
Box 64 Folder 37-38
Brenner, Dave - UC San Diego, 1986

Includes floppy disk.

Box 64 Folder 39
Britten, Roy - CalTech, 1990

Includes floppy disk.

Box 64 Folder 40
Brody, Stuart - UC San Diego, 1989