Russell Doolittle Biochemistry Laboratory Records, 1971 - 1998 (MSS 0077)

Extent: 87.4 Linear feet (83 records cartons, 8 archives boxes, 16 oversize folders and 1 art bin item)

The records (1971-1998) of Dr. Russell F. Doolittle's biochemistry laboratory at the University of California, San Diego include notebooks related to the first determination of the complete sequence of amino acids in the human fibrinogen molecule, paper files for the amino acid sequences contained in the protein sequence data bank called NEWAT, as well as other research, correspondence and Protein Society files.

Dr. Russell F. Doolittle, professor of chemistry at the University of California, San Diego, headed a campus science laboratory that conducts research in the evolutionary and structural aspects of proteins. In 1979, Doolittle's laboratory successfully analyzed the structure of the amino acid sequence for the human fibrinogen molecule.

During that study, ten to twenty postdoctoral, graduate and undergraduate researchers worked to pull apart and analyze the amino acid sequences in the alpha, beta and gamma chains of fibrinogen. Doolittle adapted a peptide synthesizing machine to break apart peptides and employed an amino acid analyzer to identify the sequences.

The peptide synthesizer, which was the second peptide synthesizer ever constructed, was modeled on the prototype designed by Bruce Merrifield, then of Rockefeller University. Merrifield was later awarded the Nobel Prize for the design of the machine.

The UCSD machine was constructed in 1964 at the instigation of Martin Kamen, a member of the Chemistry faculty. Professor Kamen had seen Merrifield's machine and, on his return to UCSD, asked Arthur Robinson, a graduate student in the Chemistry Department, to oversee construction of the machine. Robinson journeyed back to New York to examine Merrifield's machine more closely and then, after returning to UCSD, began constructing the UCSD machine.

After a period of time, the machine was converted into a peptide sequencer. Instead of building up peptides one amino acid at a time, it would take them apart one amino acid at a time. In 1979, the machine was used to make the first determination of the complete amino acid sequence for the human fibrinogen molecule, which is composed of 2,934 amino acids.

Doolittle also constructed a protein sequence data bank called NEWAT. Sequences identified in the published literature were entered into an electronic database and new sequences were searched against known sequences. In 1983, Doolittle used the data bank to link separate research efforts at the Center for Blood Research in Boston and the National Cancer Institute in Washington, D. C. He related a known cancer gene to a gene with a known function in human cells.

Doolittle participated in the Protein Society as a member and as one of the editorial board that oversaw the society publication, Protein Science.

ACCESSION PROCESSED IN 1997

The Russell Doolittle Biochemistry Laboratory Records document the activities of a UCSD science laboratory engaged in research on the structure of the human fibrinogen molecule. The materials are arranged in three series: 1) NEWAT, 2) LABORATORY NOTEBOOKS and 3) AMINO ACID SEQUENCER.

SERIES 1: NEWAT

The NEWAT series contains journal articles, printouts and summary data reports for individual amino acid sequences that were entered into the electronic data bank. The series begins with a list that relates the folder title acronym to the name and the journal citation for each amino acid sequence. The materials are arranged alphabetically by acronym.

SERIES 2: LABORATORY NOTEBOOKS

The LABORATORY NOTEBOOKS series contains notebooks by individual postdoctoral, graduate and undergraduate researchers who worked on the project. Also included are notebooks that contain amino acid analysis charts and high performance liquid chromotography charts. The notebooks are arranged by name of researcher, subproject and type of chart as follows: 2A) Watt, Ken; 2B) Bouma, H.; 2C) Takagi, T.; 2D) Miscellaneous Researchers; 2E) Electric Birefringence; 2F) Peptide Synthesis; 2G) Analysis Charts; and 2H) High Performance Liquid Chromotography Charts.

SERIES 3: AMINO ACID SEQUENCER

This is the machine adapted by laboratory staff to pull apart amino acids.

ACCESSION PROCESSED IN 2006

The accession of the Russell Doolittle Biochemistry Laboratory Records processed in 2006 is arranged in eight series: 4) CORRESPONDENCE, 5) LAB NOTEBOOKS, 6) RESEARCH, 7) NEWAT, 8) PROTEIN SOCIETY, 9) PUBLICATIONS, 10) GRANTS/BUDGETS and 11) TEACHING FILES.

SERIES 4: CORRESPONDENCE

The CORRESPONDENCE series is arranged in three subseries: A) General, B) Incoming Email and C) Outgoing Email. The General Correspondence dates from 1964 to 1998 and includes correspondence from researchers and research institutions. The Incoming Email dates from 1988 to 1997. The Outgoing Email dates from 1989 to 1997.

SERIES 5: LAB NOTEBOOKS

The LAB NOTEBOOKS series is arranged in two subseries: A) By Researcher and B) By Subject. The By Researcher subseries contains research notes by Doolittle's assistants and are arranged alphabetically. The By Subject subseries is arranged alphabetically by the topic being researched, for example, Peptide Synthesis, Biochemistry and Molecular Genetics.

SERIES 6: RESEARCH

The RESEARCH series is arranged in two subseries: A) Sequencing Research Correspondence and B) Files. The Sequencing Research Correspondence contains research information shared between Doolittle and other researchers or institutions. The Files subseries include research files and is arranged alphabetically.

SERIES 7: NEWAT

The NEWAT series contains journal articles, summary data for amino acid, sequencing and supercomputer information.

SERIES 8: PROTEIN SOCIETY

The PROTEIN SOCIETY series contains quarterly financial reports of the society from 1992-1995, annual meetings of the society, and files of the editorial board, which Doolittle was a member.

SERIES 9: PUBLICATIONS

The PUBLICATIONS series includes press and article information collected by Dr. Doolittle as he served as editor or article reviewer of various publications, and is arranged in three subseries by publication: A) Methods in Enzymology, B) Protein Science and C) PNAS. Methods in Enzymology, a series of works, is arranged alphabetically and includes articles, arranged by author, other press information and article information for the work Molecular Evolution, a volume of the series. The Protein Science subseries, a publication of the Protein Society first issued in 1992, is arranged alphabetically by author of the article. PNAS, short for Proceedings of the National Academy of Science, is arranged alphabetically by author.

SERIES 10: GRANTS/BUDGETS

The GRANTS/BUDGETS series documents grant requests, grant approvals, and grant budgets for the years 1981 to 1991.

SERIES 11: TEACHING FILES

The TEACHING FILES series, 1981 to 1996, contains course syllabi and Doolittle's preparation notes for each class. Doolittle participated in a summer science teacher program, educating lower-level science teachers, and his lecture notes are included in this series.

Container List

Accession Processed in 1997

NEWAT

Box: 1 Folder: 1
Index to acronyms
Box: 1 Folder: 2
2GPH to ATHT
Box: 2
ATPC1, -2, -3, -4, -5 to CHEY
Box: 3
CHEZ to DEGC
Box: 4
DGI7 to FBCH1
Box: 5
F7BO to GYPD 1 and 2
Box: 6
HICT to IF2B
Box: 7
IF3E to LYMH
Box: 8
M3RD to ORDN
Box: 9
OREC to PSPB
Box: 10
PSI1 to PYRP
Box: 11
SIRV to TFWS
Box: 12
TFT4 to VP2S
Box: 13
VPIM to ZUKE

LABORATORY NOTEBOOKS

Watt, Ken

Box: 14 Folder: 1-2
Book 1 - Beta Chain CNBr / Lysozyme HSer Coupling, 10/1/76 - 9/30/78
Box: 14 Folder: 3-5
Book 2 - H Beta 0 CN I, 11/1/76 - 8/31/78
Box: 14 Folder: 6
Book 3 - H Beta 0 CN V, 11/1/76 - 6/30/77
Box: 14 Folder: 7
Book 4 - H Beta 0 CN VII, 11/1/76 - 7/31/77
Box: 14 Folder: 8-9
Book 5 - H Beta 0 CN II, 11/1/76 - 9/30/78
Box: 14 Folder: 10-11
Book 6 - H Beta 0 CN VI, 11/1/76 - 12/31/77
Box: 14 Folder: 12
Book 7 - Sequence H Beta CN VId, 12/2/76 - 3/31/78
Box: 14 Folder: 13
Book 8 - H Beta CN II, Glu Cleavage, 1/1/77 - 11/30/77
Box: 14 Folder: 14
Book 9 - H Beta CN IV, 1/1/77 - 12/31/77
Box: 15 Folder: 1
Book 10 - H Beta CN III, 1/1/77 - 8/31/77
Box: 15 Folder: 2-3
Book 11 - Citraconylation, Triptic Digestion of Human 0 Beta Chain, 3/1/77 - 6/1/77
Box: 15 Folder: 4
Book 12 - H Beta CN Vb, 3/1/77 - 8/31/77
Box: 15 Folder: 5
Book 13 - CN VI C-2, CN VIf, H Beta CVI VI C-3, CN VI b-1, CN VIC-4, CN VI C-1, CN VIa, 3/1/77 - 5/31/77
Box: 15 Folder: 6
Book 14 - H Beta CN IVb, 3/1/77 - 7/31/77
Box: 15 Folder: 7-8
Book 15 - H Beta CN IIIa from Re-chromatog, 05/01/77 - 10/31/77
Box: 15 Folder: 9
Book 16 - H Beta CN IIIb, CN IVa, 07/01/77 - 08/31/77
Box: 15 Folder: 10-11
Book 17 - H Beta CN V TR, 07/01/77 - 12/31/77
Box: 15 Folder: 12
Book 18 - H Beta CN IV TR, Glu, 07/01/77 - 09/31/77
Box: 15 Folder: 13-14
Book 19 - H Beta CN IVe, 07/01/77 - 10/31/77
Box: 15 Folder: 15-16
Book 20 - H Beta CN III CT and TR, 07/01/77 - 08/31/77
Box: 15 Folder: 17
Book 21 - H Alpha 6d Ch, TR, 08/01/77 - 06/30/79
Box: 15 Folder: 18
Book 22 - H Beta CN V Glu-, 10/01/77 - 01/31/78
Box: 16 Folder: 1
Book 23 - H Beta CN III TR, 10/1/77 - 10/31/77
Box: 16 Folder: 2-3
Book 24 - H Beta CT, 11/01/77 - 01/31/78
Box: 16 Folder: 4
Book 25 - H Beta CN Ne CT, and Sequence, 12/01/77 - 12/31/77
Box: 16 Folder: 5-7
Book 26 - H Beta Glu, 12/01/77 - 2/28/78
Box: 16 Folder: 8-9
Book 27 - H Beta CN II Glu EDC Sequence, 01/01/78 - 01/31/78
Box: 16 Folder: 10-11
Book 28 - Alpha Chain CNI Sequence Summary, H Beta Glu Sequence, 02/01/78 - 05/31/78
Box: 16 Folder: 12
Book 29 - H Beta CNI GEE DITC Bends, 09/01/78 - 09/31/78
Box: 16 Folder: 13-14
Book 30 - H Alpha CN1 PL1 SP1 Ch, 10/01/78 - 03/31/79
Box: 16 Folder: 15-16
Book 31 - H Alpha CNI SPI Ch 2nd, 11/01/78 - 02/28/79
Box: 16 Folder: 17
Book 32 - PLI SP2 Ch to SGSFRP...E, ENI SP Pool 2, 01/01/79 - 02/28/79
Box: 16 Folder: 18
Book 33 - H Alpha CN1 SP2 Ch SP2dnp to Ng, 02/01/79 - 03/31/79
Box: 16 Folder: 19
Book 34 - H Alpha CN1 SP1 Ch, 02/01/79 - 03/31/79
Box: 16 Folder: 20
Book 35 - H Alpha Chain, 04/01/79 - 06/30/79
Box: 17 Folder: 1-2
Book 35, cont. - H Alpha Chain, 04/01/79 - 06/30/79
Box: 17 Folder: 3-4
Book 36 - H Alpha, Glu Digest Continuation of 1/78 Prep (70mg), 05/01/79 - 05/31/79
Box: 17 Folder: 5-6
Book 37 - H Alpha Glu (sequence) 71mg prep, 05/01/79 - 06/30/79
Box: 17 Folder: 7-10
Book 38 - H Alpha - Subscript 2 - SP 72 6 mg G50, 06/01/79 - 06/30/79
Box: 17 Folder: 11
Book 39 - Ch H Alpha CNI PLII, 03/01/78 - 07/31/78
Box: 17 Folder: 12-14
Book 40 - H Alpha - Subscript 2 - CNI Ch-, 03/01/78 - 03/31/78
Box: 17 Folder: 15-17
Book 41 - H Alpha CNI Ch Sequence, 04/01/78 - 08/31/78
Box: 17 Folder: 18
Book 42 - H Alpha, CNI Tryptophan, 04/01/78 - 06/30/78
Box: 17 Folder: 19-20
Book 43 - H Beta Chain Trypson, 04/01/78 - 05/31/78
Box: 17 Folder: 21
Book 44 - Frag. D, CN III C, TR, 05/01/78 - 07/31/78
Box: 18 Folder: 1-3
Book 45 - H Beta (CN Br), HD Beta Tryptic, 05/01/78 - 09/30/78
Box: 18 Folder: 4
Book 46 - H Alpha CNI PLI Ch, 06/01/78 - 06/30/78
Box: 18 Folder: 5
Book 47 - H Alpha CNI PLI Ch (EDC), 04/01/78 - 08/31/78
Box: 18 Folder: 6
Book 48 - H Alpha CNI PL2, Ch2, Ch1, 07/01/78 - 07/31/78
Box: 18 Folder: 7
Book 49 - II H Alpha CNI Trytophan, 08/01/78 - 03/31/78
Box: 18 Folder: 8-10
Book 50 - H Alpha CN1 PL1 Ch 2hrs, 37 degrees 1/50 ration, partially GEE, 08/01/78 - 01/31/79

Bouma, H

Box: 18 Folder: 11-13
Book 1 - I. Human Fibrinogen; Gamma Chain; Citraconyl - Trypsin, G-50; Peaks V, VI, VII, VIII, 9/1/75 - 3/31/76
Box: 18 Folder: 14-16
Book 2 - Human Fibrinogen; Gamma Chain; Citraconyl - Trypsin, G-50; Peaks II, III, IV, 9/1/75 - 12/31/76
Box: 18 Folder: 17
Book 3 - Miscellaneous: Anti-human Fibrinogen; 4, 4'-diaminobenzil; TATG synthesis, 9/1/75- 9/30/76
Box: 18 Folder: 18
Book 4 - Human Fibrinogen; Gamma Chain; Citraconyl - Trypsin, G-50; Peaks II, III, VIII, 1/1/76 - 6/30/76
Box: 19 Folder: 1-2
Book 4, cont. - Human Fibrinogen; Gamma Chain; Citraconyl - Trypsin, G-50; Peaks II, III, VIII, 1/1/76 - 6/30/76
Box: 19 Folder: 3
Book 5 - Human Fibrinogen; Gamma Chain; Citraconyl-Trypsin, G-50; Peaks V and VI, 1/1/76 - 8/31/76
Box: 19 Folder: 4-5
Book 6 - Human Fibrinogen; Gamma Chain; Citraconyl-Tripsin; G-50; Peak II; Deblocked, Trypsin, G-25, 1/1/76 - 3/31/76
Box: 19 Folder: 6-7
Book 7 - Human Fibrinogen; Gamma Chain; Succinylated, Aminoethylated; Trypsin, G-25; Peaks 1, 4, 5, and 6, 10/1/76 - 1/31/77
Box: 19 Folder: 8-9
Book 8 - Human Fibrinogen; Gamma Chain; Succinylated, 14 C-aminoethylated; Trypsin, G-25; Peaks 1, 4, 5, and 6 (synthesis: 14 C-bromoethylamine), 12/1/76 - 8/31/77
Box: 19 Folder: 10-11
Book 9 - Fibrinogen Sulfitolysis; S-sulfo Human Fibrinogen Separations; Gamma Chain Modifications (aminoethylation, cyclohexanedione, tryptic cleavages), 8/1/76 - 11/31/76
Box: 19 Folder: 12-13
Book 10 - HG, CT2 (HG, CT2, AT3) (HG, CT2, AT4 and AT5); HG CT5; HG CT6; HG CT7, 3/1/77 - 4/30/77
Box: 19 Folder: 14-15
Book 11 - HG, CT 3B; TRa-2; TRb-2, 4/1/77 - 6/30/77
Box: 19 Folder: 16-17
Book 12 - Plasmin - 0ib DE-52; CNBr-G-100 Columns; TR-G-25 Columns, 8/1/77 - 1/31/78
Box: 19 Folder: 18
Book 13 - HF, PLD, CN III B; HF, PLD, CN III C, 12/1/77 - 12/31/77
Box: 20 Folder: 1
Book 13, cont. - HF, PLD, CN III B; HF, PLD, CN III C, 12/1/77 - 12/31/77
Box: 20 Folder: 2
Book 14 - HF, PLD, CN II; HF, PLD, CN III, 2/1/78 - 5/31/78
Box: 20 Folder: 3-4
Book 15 - G - 37 1/2; HF, PLD, CN I, TRA-2; ... A-3; ... A-4, 12/1/77 - 1/31/78
Box: 20 Folder: 5-8
Book 16 - HF, PLD, CN I, TRA; HF, PLD, CN I, TRB, 12/1/77 - 3/31/78
Box: 20 Folder: 9-10
Book 17 - Frag D; CN I, TR pH 7.0; Peak B-D, 3/1/78 - 6/30/78
Box: 20 Folder: 11
Book 18 - Tryptic-digest; Human Fibrinogen; Gamma Chain, 6/1/78 - 7/31/78
Box: 20 Folder: 12
Book 19 - Fragment D; CN I, TRA; pH 7.0 Trypsin; G-25, 4/1/78 - 7/31/78

Takagi, T

Box: 20 Folder: 13-14
Book 1 - H Gamma CT Pools I, II, III, DNS; CT I, II, III TATG (electrophoresis, CNBr), 11/1/73 - 7/31/74
Box: 20 Folder: 15-17
Book 2 - H Gamma CT IV - VIII (gel filtration, paper el., ion exchange - Aminex A5), 11/1/73 - 7/31/74
Box: 20 Folder: 18
Book 3 - H Gamma CNB R and A; Trypsin I - IV (gel filtration, paper el.), 5/1/74 - 8/31/74
Box: 21 Folder: 1
Book 3, cont. - H Gamma CNB R and A; Trypsin I - IV (gel filtration, paper el.), 5/1/74 - 8/31/74
Box: 21 Folder: 2
Book 4 - H Gamma chain; AAA 24, 48,72 hr.; Tryptophan Det with Methane Sulfonic Acid; H Gamma CNI AAA 3/75, 07, 1/73 - 12/31/73
Box: 21 Folder: 3-4
Book 5 - H Gamma CNI Chymotrypsin Gel Filtration G-25 Paper El, 09/1/74 - 11/30/74
Box: 21 Folder: 5
Book 6 - H Gamma CNI Pepsin Gel Filtration G-25 Paper El, 10/1/74 - 11/30/74
Box: 21 Folder: 6-8
Book 7 - H Gamma CNI Pepsin Gel Filtration G-25 Paper El, 10/1/74 - 11/30/74
Box: 21 Folder: 9
Book 8 - Gamma CN III, IV, V, 9/1/73 - 10/31/74
Box: 21 Folder: 10-13
Book 9 - 11/73
Box: 21 Folder: 14
Book 10 - Collagenase Digestion of H0, 3/74 - 4/74
Box: 21 Folder: 15-18
Book 11 - Plasmin Digestion, 4/74 - 5/74
Box: 21 Folder: 19
Book 12 - HD, CNBr G-100 Purification, Enzyme Digestions, 1/75 - 3/75
Box: 22 Folder: 1
Book 12, cont. - HD, CNBr G-100 Purification, Enzyme Digestions, 1/75 - 3/75
Box: 22 Folder: 2
Book 13 - Separation of D and E on Biogel A 1.5 M, 4 m Guanidine, 2/74 - 7/74
Box: 22 Folder: 3
Book 14 - HDII: Separation, R and A, Purification, Enzyme Digestion, 8/74 - 12/74
Box: 22 Folder: 4-5
Book 15 - HE R and A -- G-25, Paper El, 7/74
Box: 22 Folder: 6-7
Book 16 - Gel Filtration of D and E, HE CNBr -- G-50, Paper El of Peptides, 5/74- 7/74
Box: 22 Folder: 8-9
Book 17 - HE CNBr (S-S) in E, Purification of CNBr Peptides, 8/74 - 1/75
Box: 22 Folder: 10-11
Book 18 - FIIB-2, FIIB-3, FIIB-4, FIIB-5, D-D3, 2/74 - 2/75
Box: 22 Folder: 12-13
Book 19 - CNBr Digestion of H Fibrin, 10/74 - 2/75
Box: 22 Folder: 14-15
Book 20 - TATG of H Fragments D, E, 2/74
Box: 22 Folder: 16
Book 21 - H0 CNBR, H Gamma CNBr, 2/74 - 5/74
Box: 22 Folder: 17
Book 22 - H 14C GEE Labelled Gamma Chain, Fragments from Plasmin Digestion of H GEE Fibrins, 2/74 - 5/74
Box: 22 Folder: 18
Book 23 - TATG of H Fragment D, E (see envelope), 5/74 - 8/74
Box: 22 Folder: 19
Book 24 - Human Gamma G-50, Purfication of Pools 4.5 and 6, Enzyme Digestion of Cyanogen Bromide Pools, 12/74 - 02/75
Box: 23 Folder: 1-2
Book 25 - Beta chain CNBr, G-100 10% HAc Purfication, 08/74 - 12/75
Box: 23 Folder: 3-4
Book 26 - Separation of H Gamma, Beta Chains CM52, Beta Chain CNBr Peptides AAA, 03/74
Box: 23 Folder: 5
Book 27 - Bov Gamma CNBr A,B,C, AAA (Bovine)
Box: 23 Folder: 6
Book 28 - Oxidized Bov Gamma Chain and Its CNBr Fragments, Separation Biogel 1.5 Purification by Paper El, 01/74 - 02/74
Box: 23 Folder: 7
Book 29 - H Fragment A from Plasmin, digest 10', 90', 15 hrs, Enzyme Digestion, 05/72
Box: 23 Folder: 8-11
Book A - HF XIII: H "X" Trypsin ( Thermolysin, Chymotrypsin ); PCAase, Pronase, CPase; HX for TATG; P - Ser; Pepsin; Platelet "X", 12/01/72 - 10/31/73
Box: 23 Folder: 12-13
Book B - Preparation of BF XIII, HF XIII (Biogel A1.5, Platelet F XIII, DE-52 SOS gels); Activation of F XIII; Trypsin Dig. of 14C GEE F XIII; Sulfitolysis of F XIII *; Separation of A and B Chains of F XIII *, 09/01/72 - 09/30/73
Box: 23 Folder: 14-16
Book C - TATG: H, B FXIII, FXIII *; ClG; Platelet F XIII *; Seattle F XIII *, 11/01/72 - 11/31/73
Box: 23 Folder: 17-18
Book D - Bov P "X" F XIII; Preparation; Trypsin Digestion; Chymotrypsin; PCA to Th; Trypsin to Th, 10/01/72 - 10/31/73
Box: 23 Folder: 19
Book E - Bov Gamma ( plasmin, trypsin SDS gels ); GEE B Gamma - Plasmin; B 0 plasmin, 08/01/72 - 03/31/73

Miscellaneous researchers

Box: 24 Folder: 1-2
Friezner, S. - H Gamma CNI Trypsin, 06/75
Lin, Y
Box: 24 Folder: 3
H 14C GEE Alpha Electrophoresis; T-boc Reactions T-boc-EA, 02/01/71 - 05/31/71
Box: 24 Folder: 4-5
Synthesis of HFpA; A-D-S-G-E-G-D-F-A-A-0; Preparation of Bovine Insulin; A and B Chains, 02/01/71 - 05/31/74
Box: 24 Folder: 6
Maffly, B. and Goldbaum, D. - HPLC, 04/76 - 01/78

Electric Birefringence

Cottrell, B
Box: 24 Folder: 7-8
Book 1, 1973
Box: 24 Folder: 9-11
Book 2 - Photographs, computer programs and basic user manual, 1973 - 1974
Box: 24 Folder: 12-13
Book 3, 1974
Box: 24 Folder: 14-15
Book 4, 1975
Box: 24 Folder: 16-17
Book 5, 1975
Box: 24 Folder: 18
Computer Graphs B/C
Box: 25 Folder: 1
Computation Book, Oct 22, 1973
Box: 25 Folder: 2-3
Computer Graphs, Upsilon, Theta
Box: 25 Folder: 4-5
Data Output. Elbra
Box: 25 Folder: 6-7
Log Book
Box: 25 Folder: 8-9
Troll, M. - System logic of the laser birefringence machine, reprints, technical information, equipment specifications

Analysis Charts

Box: 27 Folder: 4
2 VB Sequence
Box: 27 Folder: 5
AAA of Gamma Chains Trp Det
Box: 27 Folder: 6-8
Bead Data SP Digest of PLI
Box: 27 Folder: 9
Bov Gamma Chains, 1973
Box: 27 Folder: 10
Bov Gamma Chains II
Box: 27 Folder: 11
CN I, PL I, SP I, PL II, Tryptic Data, Chymo, SP Peptides, 1979
Box: 27 Folder: 12
CN - V B, C, and D - B Gamma CN from pH2, SC - pH 9.5, CN5B - pH 9.5, SD - pH 4.5
Box: 27 Folder: 13
CNBr, Cyanogen Bremide G-75 Runs
Box: 27 Folder: 14-15
Cys from PL2, SP PLI Parp #6, SP Digest CNI #3, SP Digest CNI #4
Box: 27 Folder: 16
D1 Binder D1 Non Binder 12/80 R and A Trypsin
Box: 28 Folder: 1
D2 Alpha - Trypsin
Box: 28 Folder: 2
D2 Rho Glass Beads
Box: 28 Folder: 3-4
H Alpha 2, CNI, TFA, CN IB, Trypsin
Box: 28 Folder: 5-6
H2 CN I PL I Se #2, S rho I TR - G-25
Box: 28 Folder: 7
H Alpha CNI CNBr = 70% TFA, H0CNI Pl I Glu, Pl 2 Glu
Box: 28 Folder: 8
H and CNI PL 3
Box: 28 Folder: 9-10
H Alpha 2, 1977
Box: 28 Folder: 11
H Alpha CN, 1976
Box: 28 Folder: 12-14
H Alpha CN III, 1976 - 1978
Box: 28 Folder: 15-16
H Alpha CN IV, 1975
Box: 28 Folder: 17
H Alpha CN4A
Box: 28 Folder: 18
H Alpha CN IV B
Box: 29 Folder: 1
H Alpha CN31
Box: 29 Folder: 2
H Alpha CN5B
Box: 29 Folder: 3
H Gamma Chain CN IV, 1975
Box: 29 Folder: 4
H Alpha CN CN -VII, 1977 (1 of 2)
Box: 29 Folder: 5
H Gamma Chain CN V-VII, 1977 (2 of 2)
Box: 29 Folder: 6
HD R and A BC 1980 D1 Gamma D3 Gamma Trypsin
Box: 29 Folder: 7-9
H Gamma chain, 1971-1972
Box: 29 Folder: 10
Gamma Chains Preps CN III, CNIV
Box: 29 Folder: 11
HXLF CEE 7177 CN I Tal 23
Box: 29 Folder: 12
Machine H Alpha CN III "G7B", 1976
Box: 29 Folder: 13
Mellitin Sequence Run, 07/18/80
Box: 29 Folder: 14
Sequence Guide 1969-70
Box: 29 Folder: 15
Sequenator log sheet
Box: 30 Folder: 1-2
SP Digest #4 PLI, TR Digest Over G.50
Box: 30 Folder: 3
SP Digest CNI #6, SP Digest CNI #9 (8/79), SP Digest CNI #11 (4/79)
Box: 30 Folder: 4
SP of PLI #3, SP of PLI #5, 11/15/78
Box: 30 Folder: 5
Trypsin Digest
Box: 30 Folder: 6-15
Untitled

High Performance Liquid Chromotography Charts

Box: 31 Folder: 1-3
Untitled
Box: 31 Folder: 4
Acylase, N-Ac-Ab-C-Sar
Box: 31 Folder: 5
CMC
Box: 31 Folder: 6
Electrofocusing
Box: 31 Folder: 7
Funatsu Peptide
Box: 31 Folder: 8
HPLC Anion Exchange

Peptide Synthesis

Box: 25 Folder: 10
BM Biochemica - Vol. 2 Number 3, 1985
Box: 25 Folder: 11
Book 9
Box: 25 Folder: 12
Book 10
Computation Notebooks
Box: 25 Folder: 13-18
Notebooks 1-6
Box: 26 Folder: 1-6
Notebooks 7-12
Box: 26 Folder: 7
Deoxynucleotide Synthesis, Phosphonylations, Monomer Synthesis, Dimer Synthesis
Box: 26 Folder: 8
DNA Sequencing 3:728-3D, 1985
Box: 26 Folder: 9
D.T. Peptide Synthesis
Box: 26 Folder: 10
Evans, Barbara - Untitled notebook
Box: 26 Folder: 11
Gel Sequencing
Box: 26 Folder: 12
Helices
Box: 26 Folder: 13
Lab Reports
Lamprey Transferrin
Evans, Barbara
Box: 26 Folder: 14-15
Untitled, 1983
Box: 26 Folder: 16
DNA Sequencing 463-1B, 1985 - 1986
Box: 26 Folder: 17
Plasmid Preps, 1984
Box: 26 Folder: 18
Sequence 1 Molecular Biology, 1984 - 1985
Box: 26 Folder: 19
Sequencing 2: 613-3B, 463-1B, 1985
Box: 26 Folder: 20
Nucleotide Synthesis - Ologonucleotide Probes, 1982
Box: 26 Folder: 21
Peptide Synthesis - James Kobut/R. Doolittle
Box: 27 Folder: 1-2
Pontes, Manuel
Box: 27 Folder: 3
RD and MTNICB0

AMINO ACID SEQUENCER

Oversize: AB-00-01
Sequencer

Accession Processed in 2006

CORRESPONDENCE

General

Box: 33 Folder: 1
Canadian Institute for Advanced Research correspondence
Box: 33 Folder: 2
Correspondence (Fitch, Hampton, Laursen and Mawe), 1969 - 1970
Box: 33 Folder: 3
Correspondence with Dr. David Waxman, 1981
Box: 33 Folder: 4
Correspondence with Dr. Hawiger, 1980
Box: 33 Folder: 5
Correspondence with Dr. Walter
Box: 33 Folder: 6-19
1964 - 1977, June
Box: 34 Folder: 1-13
1977, July - 1983
Box: 35 Folder: 1-11
1984 - 1987
Box: 36 Folder: 1-13
1987 - 1991, September
Box: 37 Folder: 1-9
1991, October - 1994
Box: 38 Folder: 1-10
1995 - 1998
Box: 39 Folder: 1-8
1999 - 2003
Box: 39 Folder: 9
Ivan Rayment (collaboration)
Box: 39 Folder: 10
Letters from Russell F. Doolittle
Box: 39 Folder: 11
Old correspondence
Box: 39 Folder: 12
Patent Application, 1981
Box: 39 Folder: 13
Protein Folding Discussion Group, March-May, 1991
Box: 39 Folder: 14
Russell F. Doolittle mail and general instructions
Box: 39 Folder: 15
Sabbatical correspondence
Box: 39 Folder: 16
"Synthetic Peptide Antipolymerants of Fibrin" patent, March, 1982
Box: 39 Folder: 17
Uppsala University- Bioinformatics
Box: 39 Folder: 18
Virgil Woods' HIV Project: Detection and Characterization of Human Germline Incorporation of HIV-1
Box: 39 Folder: 19
Wei Duan's Thesis Exam

Incoming Email

Box: 40 Folder: 1-19
1988, January - 1993, April
Box: 41 Folder: 1-20
1993, May - 1995, January
Box: 42 Folder: 1-18
1995, February - 1996, May
Box: 43 Folder: 1-15
1996, June - 1997, August
Box: 44 Folder: 1-3
1997, September - 1997, November , 1997

Outgoing Email

Box: 44 Folder: 4
Human Genome Project newsletters, December, 1989-March, 1990
Box: 44 Folder: 5
1985 - 1988
Box: 44 Folder: 6-24
1988, May - 1996, March
Box: 45 Folder: 1-8
1996, April - 1997, December

LABORATORY NOTEBOOKS

By Researcher

Box: 46 Folder: 1
Abanes, De Mello, Angelica - Bio Rotation - FReP, September 23 - November 1, 1996
Box: 46 Folder: 2
Aldaz, Hector, July 1 - September 1, 1992
Box: 46 Folder: 3
Bouma, Bud - Daily Log, September 15 - December, 1975
Box: 46 Folder: 4
Bystroff, Chris - "Doolittle Lab" Summer Rotations, July - September, 1983
Cairns, Jim
Box: 46 Folder: 5
Book 1. Clotting Experiments-Peptide Purification, August 3 - November 30, 1993
Box: 46 Folder: 6
Book 2. Project PGPRV-Reagent Preparation, 1993 - 1994
Box: 47 Folder: 1
Book 3.The Continuing Saga of the Disulfide Ring Peptide (796), December 2, 1993 - June 22, 1994
Box: 47 Folder: 2
Book 4. Fragment E. Digestion/Disulfides, May 18, 1994 - January 11, 1995
Box: 47 Folder: 3
Book 5. Disulfide Ring Peptide, June 22-September 27, 1994
Chen, R
Box: 47 Folder: 4-5
Book 1: Chromatography of S-SO3 chains of BOV Phi F.XLF G-200 (6M urea) CM52, December-Feb., Dec. 1968 - Feb. 1970
Box: 47 Folder: 6
Book 2: Rabbit Light Chain Enzyme digestions and chromatography S-Sulfo Phi Chromatography and AAA, 1968
Box: 47 Folder: 7
Book 3: C14-Gee-"gamma" Bovine AAA, June 1969 - August 1971
Box: 47 Folder: 8
Book 4: B gamma C-14 GEE gamma Enzyme digestions Chromatograms Electrophoresis, June 1969 - December 1970
Box: 47 Folder: 9
Book 5: Bov crosslinking expts. Amino Acids Analysis, January 1969 - February 1970
Box: 47 Folder: 10
Book 6: Bov gamma-gamma TypeI trypsin Chromatography CM 52 G-100, July 1969 - July 1970
Box: 47 Folder: 11
Book 7: AAA of 14C HgammaGee peptides from chromatography & el. 14C Halpha peptides from chromatography & el., 1970
Box: 47 Folder: 12
Book 8: Human 14C GEE fibrin CM52 Trypsin digestion of H "gamma" G-25 electrophoresis, December 1969 - July 1970
Box: 47 Folder: 13
Book 9: HXLF GEE CM52 H&B XLphi Oklahoma F on CM52, 1970
Box: 47 Folder: 14
Book 10: Paper el. of: 14C Hgamma Th exp. mix control mis tryptic bovine gamma Oklahoma Pool 5 and bt glu-ala, 1970
Box: 47 Folder: 15
Book 11: Crosslinking experiments EDMANS, December 1969 - December 1970
Box: 47 Folder: 16
Book 12: Uvicon Scans of various Sephadex Columns Data from scintillation counters, 1970
Box: 48 Folder: 1-3
Cho, Glen - Preparation of phi and metal derivatives, 1995 - 1996
Box: 48 Folder: 4
Clason, G.W., and M.E. Riley - Enzymology, 1969 - 1970
Box: 48 Folder: 5
Clinton, Gail - Rotator, Phosphorylated Serine in Fibrinogen, 1969
Cottrell, B
Box: 48 Folder: 6
February, 1973 - December, 1974
Box: 48 Folder: 7
Hgamma CN3, Hgamma CNBC, Hgamma SC digest, December 1980
Box: 48 Folder: 8
February 1980 - January 1983
Box: 48 Folder: 9
Book 1. Project DNA Sequencing, October 29 - November 29, 1984
Box: 48 Folder: 10
Evans, Barbara R. - Lamprey Molecular Biology: Northerns and Southerns, September - October 1986
Everse, Stephen
Crystal Book
Box: 48 Folder: 11-14
Books 1-4, 1990 - 1994
Box: 49 Folder: 1-3
Books 5-7, 1994 - 1997
Box: 49 Folder: 4-6
Project 0 - Books 2-4, 1990 - 1991
Box: 49 Folder: 7-15
Project H0 - Books 5-13, 1991 - 1998
Box: 49 Folder: 16
Book 1. Rotation, January 5 - June 23, 1990
Box: 50 Folder: 1
Models, July 23, 1994 - July 11, 1998
Box: 50 Folder: 2
Fann, Wen-Pang
Feng, Da Fei
Box: 50 Folder: 3
August 1982 - July 1983
Box: 50 Folder: 4
April - October 1991
Box: 50 Folder: 5-6
CRB 233 UCSD, 1983 - 1985
Box: 50 Folder: 7-8
CRB 319 UCSD, 1985 - 1988
Box: 50 Folder: 9
Divergence, May 1994 - November 1999
Box: 50 Folder: 10
Gas Project, July 7, 1988 - December 1989
Box: 50 Folder: 11
Foreman/Freunal, Laura, November 1999 - May 2000
Gray, Jeff
Box: 50 Folder: 12
Book 1. Project Research, April 15, 1986 - February 2, 1987
Box: 50 Folder: 13
Book 2. Project Research, February 5 - October 20, 1987
Box: 50 Folder: 14
Book 3. Project 7n/3 535-5D, October 26, 1987 - October 6, 1988
Box: 50 Folder: 15
Book 4. Project LMPP/LFerritin/AlphaChains, September 1988 - October 27, 1989
Box: 50 Folder: 16
Book 5. Project Zamprey Album, November 1, 1989 - October 5, 1990
Box: 51 Folder: 1
Peptide Solubility versus composition/size, August 13 - October 22, 1986
Box: 51 Folder: 2
Book 1. Retroviral Gag Proteins and Related Sequences, October 15, 1985 - January 14, 1986
Box: 51 Folder: 3
October 1990 - March 1991
Box: 51 Folder: 4-6
Handy, Jacob, 1997 - 1999
Box: 51 Folder: 7
Haschemeyer, A. Visiting Scientist - Fibrinogen, March 1975
Healey, Carol
Box: 51 Folder: 8
Lipocalins/Fatty Acid Binding Proteins, April 9 - July 30, 1993
Box: 51 Folder: 9
Protinase Inhibitors PSTI Basic, August 2, 1993
Box: 51 Folder: 10
Hiroyuki, Tom, Winter 1992
Box: 51 Folder: 11
Huang, Mai, 1998 - 2000
Box: 51 Folder: 12
Hucko, Judy, 1974 - 1975
Box: 51 Folder: 13
Jacque, Jean - ATA, 1980 - 1981
Box: 51 Folder: 14-15
Johnson, Aaron, 1989 - 1990
Box: 51 Folder: 16
Kamps, Mark - (Rotator), Rotation 1, October - November, 1981
Box: 51 Folder: 17
Keil, Andrea - DNA/RNA Extraction, 1982
Box: 51 Folder: 18
Kuei, Debbie and Jung Wang - Biochemistry , May 5 - September 30, 1986
Box: 51 Folder: 19
Lane, Ray, Fall 1978
Box: 51 Folder: 20
Lau, Francis - Master's Lecture UCSD, April - September, 1970
Laudano, Andrew
Box: 51 Folder: 21
Book 1. Research, May 23 - September 13, 1977
Box: 52 Folder: 1
Book 2. Project Chemistry Research, September 14 - November 11, 1977
Box: 52 Folder: 2
Book 3. Project Chem Research, December 11, 1977 - June 22, 1978
Box: 52 Folder: 3
Book 4. Project Chemistry Research, June 24 - November 5, 1978
Box: 52 Folder: 4
Book 5. Project Chemistry Research, January 5 - January 27, 1978
Box: 52 Folder: 5
Book 6. Biochemistry Research, January 29 - March 26, 1979
Box: 52 Folder: 6
Book 7. Biochemistry Research, March 27 - June 20, 1979
Box: 52 Folder: 7
Book 8. Project Biochemistry Research, June 20 - October 15, 1979
Box: 52 Folder: 8
Book 9. Project: Chemistry Research, May 15 - December 23, 1979
Box: 52 Folder: 9
Book 10. Project Chemistry Research, December 22, 1979 - February 25, 1980
Box: 52 Folder: 10
Book 11. Biochemistry Research, February 25 - April 23, 1980
Box: 52 Folder: 11
Book 12. Project Biochemistry Research, April 24 - July 20, 1980
Box: 52 Folder: 12
Book 13. Biochemistry Research, July 21, 1980 - May 22, 1982
Box: 52 Folder: 13
Leong, Jane - Rotation, May 5 - June 7, 1989
Little, Elizabeth
Box: 52 Folder: 14
Book 1. Project Alpha-XL, October 1993 - February, 1994
Box: 52 Folder: 15
Book 1. Project Gels, November 29, 1993 - May 26, 1994
Box: 52 Folder: 16
Book 2. Project Alpha XL-2, February - June 1994
Box: 52 Folder: 17
Maffly, Bob, 1977 - 1978
Box: 52 Folder: 18
Maher, David - Rotation, May 1986
Box: 52 Folder: 19
Malden, Marx, December 26, 1991
Box: 53 Folder: 1
McAllister, Ryan - Percent identity/percent similarity data, Summer 1999
Box: 53 Folder: 2
Mross, George, 1975 - 1976
Nagel, Glenn
Box: 53 Folder: 3
#1, August 16 - May 30, 1990
Box: 53 Folder: 4
#2, June 4, 1990
Box: 53 Folder: 5
Nicewander, Penelope H., March 28 - July 1990

Subject: Sequences

Pan, Yang
Box: 53 Folder: 6
Book 1, April 29 - December 11, 1987
Box: 53 Folder: 7
Book 2, December 14, 1987 - October 29, 1988
Box: 53 Folder: 8
Book 3, November 1, 1988 - September 12, 1989
Box: 53 Folder: 9
Book 4, September 14, 1989 - April 27, 1990
Box: 53 Folder: 10
Book 5, May 1 - December 5, 1990
Box: 53 Folder: 11
Book 6, December 17, 1990 - August 28, 1991
Box: 53 Folder: 12
Book 7, August 30, 1991 - October 16, 1992
Box: 53 Folder: 13
Pankratz, Dan - Rotator, 1997 - 1998
Box: 53 Folder: 14
Patterson, John - Sequencing Alpha Chain Fibrinogen, 1987 - 1988
Box: 53 Folder: 15
Picknar, Kathy - Book 1. Rotation, September 26 - December 17, 1986
Pontes, Manuel
Box: 53 Folder: 16
Oligonucleotide Chemistry, January 16, 1981 - February 23, 1983
Box: 53 Folder: 17
April 16, 1981 - May 13, 1982
Box: 54 Folder: 1
Book 3. Molecular Biology, March 1, 1983 - January 3, 1984
Box: 54 Folder: 2
Book 4. Molecular Biology, January 9 - July 4, 1984
Box: 54 Folder: 3
Book 5. Molecular Biology, July 4, 1984 - June 5, 1985
Box: 54 Folder: 4
Book 6. Molecular Biology, June 11, 1985 - March 19, 1986
Box: 54 Folder: 5
Book 7. Molecular Biology, March 19 - May 28, 1986
Box: 54 Folder: 6
315 CRB, April 8 - December 2, 1985
Box: 54 Folder: 7
Project LMP 2, February 13 - July 19, 1986
Box: 54 Folder: 8
Rabbit Book - Immunocogy, 1974 - 1976
Box: 54 Folder: 9
Rhoades, Chris, June - July 1993
Riley, Marcia
Box: 54 Folder: 10
Human Genetics Program Project "Cost" Book, 1975 - 1979
Box: 54 Folder: 11
Human Genetics Program, 1975 - 1979
Box: 54 Folder: 12
Project E-Coli, March 1 - October 11, 1983
Box: 54 Folder: 13
Riley, M. and R. Doolittle, 1999 - 2000
Box: 54 Folder: 14-16
Rojas, Ana, 2000 - 2002
Box: 54 Folder: 17
Ryckewhert, 1983 - 1986
Shimizu, Akira
Box: 55 Folder: 1-3
Books 1-3. Photo Affinity Labeling, 1987 - 1989
Box: 55 Folder: 4
Peptide Synthesis, 1987 - 1989
Shipwash, Ed
Box: 55 Folder: 5
August 2, 1994 - April 19, 1995
Box: 55 Folder: 6
Book 1, August 2 - December 27, 1993
Box: 55 Folder: 7
Book 2. Project Alpha 2, 1993 - 1994
Box: 55 Folder: 8
Book 3, April 15 - May 16, 1994
Box: 55 Folder: 9
Project Tissue Factor, August 2 - September 8, 1993
Box: 55 Folder: 10
Thompson, Katie. Russell Doolittle lab, April 5 - July 1988
Box: 55 Folder: 11
Wetzel, Glenn, October 4 - December 16, 1978
Box: 55 Folder: 12
Wilson, Carolyn Anne. Project Brad Nolen, September 24 - December 11, 1992
Box: 55 Folder: 13
Wooding, Gretchen, June 1970
Xu, Xun
Box: 55 Folder: 14
February 22 - June 12, 1990
Box: 55 Folder: 15
Book 2, 1989 - 1990
Box: 55 Folder: 16
Project Sequence, 1985 - 1986
Yamazumi, Kensuke
Box: 55 Folder: 17
Book 1, 1990 - 1991
Box: 56 Folder: 1-3
Books 2-4. Photoaffinity labeling of frag. D1 with GPRK, 1991 - 1992
Box: 56 Folder: 4
Book 5. Photoaffinity labeling of frag. D1 with GPRC and GPRPK, 1991 - 1992
Box: 56 Folder: 5
Book 6. Photoaffinity labeling of frag. D1 with GHRPK and GHRK, 1992
Box: 56 Folder: 6
Book 7. Project GHRPx and GPRPnh2, May 26 - August 30, 1992

By Subject

Box: 56 Folder: 7
Phi CNI, PL1 TR AA Analyses, Peptides, GEE, A1 I - B. Cottrell, May - September 1978
Auto Solid Phase Peptide Synthesis
Box: 56 Folder: 8
No. 1, November 1983
Box: 56 Folder: 9
No. 2, April 4 - September 19, 1984
Box: 56 Folder: 10
No. 3, September 19, 1984 - February 14, 1985
Box: 56 Folder: 11
No. 4, February 15, 1985
Box: 56 Folder: 12
No. 5, undated
Box: 57 Folder: 1
No. 6, May 12, 1986
Box: 57 Folder: 2-5
Nos. 7-10, undated
Box: 57 Folder: 6
No. 11, August 1990 - July 1991
Box: 57 Folder: 7
No. 12, July 1991
Box: 57 Folder: 8-9
Nos. 13-14, undated
Box: 57 Folder: 10
Biology, Doolittle lab rotation - Rex Kerr, February - March 1997
Bohanus
Box: 57 Folder: 11
V.1, December 5, 1983 - April 17, 1984
Box: 57 Folder: 12
V.2, April 23 - September 23, 1984
Box: 57 Folder: 13
V.3, September 24, 1984
Box: 57 Folder: 14
V.4 - Beta Chain 2C 610, February 25, 1985
Box: 58 Folder: 1
cDNA Library - Book #5- Yu, Caroline, September - November 1986

Includes gel pictures and graphs

Box: 58 Folder: 2
cDNA Library - Book #6- Yu, Caroline, December 1986 - February 1987

Includes gel pictures and graphs

Box: 58 Folder: 3
Circular Dichrolsm Machine Log, May 1980 - February 1987
Box: 58 Folder: 4
Center for Molecular Genetics - Peptide Synthesizer 990, Igor Mochalkin
Box: 58 Folder: 5
CMG 213, GHRP-NH2 HPLC - Colin Aston, August 2, 2000
Box: 58 Folder: 6
Colony Hyb with Syn. Probes - Strong, D., March 1983

Includes X-Rays

Box: 58 Folder: 7
Computer Aided Protein Evolution Studies - Woodbury, Neil, June 1978
Box: 58 Folder: 8
Computer Guide - Woodbury, Neil
Box: 58 Folder: 9
Computer Maintenance - Woodbury, Neil, October 28, 1978
Box: 58 Folder: 10-13
DNA Sequence L Alpha 713-3D - Yu, Caroline, 1985 - 1986

Includes gel pictures

Box: 58 Folder: 14
E1 E2 E3 - Bgamma, Trypsin

Folder 2 of 2

Box: 58 Folder: 15
Electric Birefringence, E.B. Summary, EDTA EXPT - R. Doolittle & B. Cottrell, Summer 1974
Box: 58 Folder: 16
Fibrinogen Preparations, Human, Lamprey, Mule, Opossum, Boxine, Rabbit, Rat, Mouse, Sheep. Includes graphs - Riley, Marcia, Russell Doolittle and Barbara Cottrell et. al., September 1972 - December 1976
Box: 58 Folder: 17
Fibrinopeptides-Part 1-Doolittle, Russell, et. al., 1968 - 1969

March-September. Mandrill, Chimpanzee, Collared Peccary, Mouflon, White Fallow Deer, Golden Jackal, South American Tapir. Including C. Glasgow. Contains graphs.

Box: 59 Folder: 1
Fibrinopeptides-Part 2-Doolittle, Russell, et. al., 1968 - 1969

March-September. Mandrill, Chimpanzee, Collared Peccary, Mouflon, White fallow Deer, Golden Jackal, South American Tapir. Including C. Glasgow. Contains graphs.

Box: 59 Folder: 2
Fragment E, R and A, E1E2E3, RD/SD/BC, September, 1978

Folder 1 of 2

Box: 59 Folder: 3
Gel Book #2- Riley, Marcia, 1987 - 1988

November-September. Includes gel photos.

Genomic Library L Alpha B1
Box: 59 Folder: 4
Book #7- Yu, Caroline, 1987

March-July. Includes gel pictures.

Box: 59 Folder: 5
Book #8- Yu, Caroline, 1987

July-August. Includes gel pictures.

Box: 59 Folder: 6
Hgamma, HgammaCN3+4, Trypsin, January, 1981
Box: 59 Folder: 7
H alpha CNI, GLU Beads, Pools 4-7, 4-7
Box: 59 Folder: 8
HPLC
Box: 59 Folder: 9
Human Cross- Link Fibrin - Doolittle, R. F. and Barbara Cottrell., 1978 - 1979

June-January. Includes graphs.

Box: 59 Folder: 10
Human Fibrinogen, Alpha Chain CNBr, April-January, 1975 - 1979

Cottrell, Barbara and Marcia Riley, et. al. and Human Fibrinogen Alpha Chain CNBr, 1976 July- Cottrell, Barbara. Includes graphs.

Box: 59 Folder: 11
Human Fibrinogen Sequences, Alpha Chain CNBR-Cottrell, Barbara., 1975 - 1978

December-March. Includes graphs.

Box: 59 Folder: 12
Human Fibrinogen, Alpha Chain CN-5-Part 1- Cottrell, Barbara, 1975 - 1976

July-March. Includes graphs

Box: 59 Folder: 13
Human Fibrinogen, Alpha Chain CN-5-Part 2- Cottrell, Barbara, 1975 - 1976

July-March. Includes graphs.

Box: 59 Folder: 14
Human Fibrinogen, Alpha Chain CNBr GEE- Strong, Donna and Cottrell, Barbara, 1978 - 1979

October-June. Includes graphs.

Box: 60 Folder: 1
Human Fibrinogen, Alpha Chain, CNBr, PL - Strong, Donna., 1978

May-October. Includes graphs.

Box: 60 Folder: 2
Human Fibrinogen, Alpha Chain CNBr, Staph Protease - Cottrell, Barbara., 1978 - 1979

November-February. Includes graphs.

Box: 60 Folder: 3
Insert Gel Book- Riley, Marcia, 1985 - 1987

February-October. Includes gel pictures.

Box: 60 Folder: 4
JJR, June, 1982
Lab Notebook
Box: 60 Folder: 5-9
Cooke, Tracy, 1988

September-December

Box: 60 Folder: 10
Graham, David, 1987

Includes gel pictures

Box: 60 Folder: 11
Yu, Caroline, April 1, 1985
Box: 60 Folder: 12-13
Yu-then, Wang

Undated. Includes gel pictures.

Box: 60 Folder: 14-15
Lamprey Albumin, cDNA - Gray, Jeff, 1988 - 1990

December-May

Box: 60 Folder: 16
Lamprey Liver, c-DNA Screening, June-July, 1984 - 1986

Doolittle Lab

Box: 60 Folder: 17
LEECH Hirudin Prep. - Doolittle, R. F., et. al., 1977 - 1978

October-May. Includes graphs.

Box: 61 Folder: 1
Lobster and Fibrinogen, July-May, 1972 - 1973

B. Cottrell, K. Cassman

Box: 61 Folder: 2
Log-Manoj-George, Summer, 1987
Box: 61 Folder: 3
'Matt' Rotation, February, 1993
Box: 61 Folder: 4
Molecular Genetics HPLC THUC TO
Box: 61 Folder: 5
More Programs for the PDP 11/04- Woodbury, Neil, March, 1979
Box: 61 Folder: 6
New Juno, February 19, 1993
Box: 61 Folder: 7
Nicewander, Penelope N., January 8, 1990
Box: 61 Folder: 8
Notes on Computer 1- Goyal, Manoj, April 24, 1987
Box: 61 Folder: 9-10
Oligonucleotide Synthesis, 1982 - 1983

Lab methods and summary

Box: 61 Folder: 11
PDP 11/04 Notes and Programs- Woodbury, Neil, March-March, 1978 - 1979
Box: 61 Folder: 12
Restriction Enzyme and Plasmid Inventories- Ellis, Carmen and Lisa Phanton, 1984 - 1986

October-December

Box: 61 Folder: 13
Rotations Fall, 1996
Box: 61 Folder: 14
Setting up Mini-Unix-Sixth Addition
Box: 61 Folder: 15
Smith, Mike, Spring, 1991
Box: 61 Folder: 16
Smith, M.W.
Staph Clumping Factor
Box: 61 Folder: 17
Strong, D., 1980

February-May. Includes graphs and pictures.

Box: 61 Folder: 18
Fragment D, etc. - Part 1- Strong, D., et. al., 1981

March-June. Includes graphs.

Box: 62 Folder: 1
Fragment D, etc. - Part 2- Strong, D., et. al., 1981

March-June. Includes graphs.

Box: 62 Folder: 2
TATG Lob phi, 1980
Box: 62 Folder: 3
TATG Synthesis- Woods, Virgil and Russell Doolittle, George Moss, and John Sharp., 1973 - 1975

July-March

Box: 62 Folder: 4
Variant Human Fibrinogen ("D.MARR"), Thrombin-Inhibitors-Weinstein, Mark and Russell Doolittle., 1971 - 1972

May-May. Contains graphs.

Box: 62 Folder: 5
Vax Log-Zeus, Johnson, M., June 17, 1985
Box: 62 Folder: 6
Webb, Jenn, April 1, 2002
Box: 62 Folder: 7
Weigh Book, Doolittle, August-December, 1965 - 1973
Xun Xu
Box: 62 Folder: 8
cDNA Sequencing (1) LMPI, June 3-October 1, 1985
Box: 62 Folder: 9