Microscopy product ID: 8063
Processed mosaic of a sagittal section through the brain of mouse model of glioma. To produce transformed cells, creGFAP mice were injected in the cortex with Ras/s.i.p53 virus and perfused after 5 weeks. In this system, GFP is introduced by the virus and expression is induced by an IRES site in the mRNA. Thus, the GFP gene is expressed whenever the virus infects a cell expressing GFAP (green). The section was immunolabeled for nestin (red) and counterstained with DAPI (blue). See MP:7857 for a section from the same brain labeled with GFAP.
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- Microscopy product: 2010-06-15. Project: 2007-06-01.
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Product type: MOSAIC. Microscopy type: MULTIPHOTON. Instrument: Nikon RTS 2000 multiphoton microscope
- Related Publications
Friedmann-Morvinski D, Bushong EA, Ke E, Soda Y, Marumoto T, Singer O, Ellisman MH, Verma IM (2012). Dedifferentiation of neurons and astrocytes by oncogenes can induce gliomas in mice. Science, 338(6110):1080-1084. doi: 10.1126/science.1226929 PMCID: PMC3595315
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