Endow, Sharyn A.; Miller, Sara E.; Thao Ly, Phuong (2022). CIL: 50729, Drosophila melanogaster. In Cell Image Library. UC San Diego Library Digital Collections. Dataset. https://doi.org/10.6075/J00K280C

We show in this study that brain and intestinal stem cells of Drosophila contain a new type of cytoplasmic protrusion which is enriched in mitochondria and that the mitochondria are probably dependent on microtubules for their distribution. The protrusions form mitochondria-enriched cytoplasmic bridges from the stem cells to their niche that we speculate are important in regulating stem cell quiescence and activation.

• 2022

• Endow, Sharyn A.
• Miller, Sara E.
• Thao Ly, Phuong

Specimen preparation: Larval brains (LBs) were prepared from starved (amino acid-restricted) first instar (L1) larvae to enrich for quiescent neural stem cells. The LBs were glutaraldehyde-fixed, tannic acid and OsO4-stained, embedded in resin, thin-sectioned (60-70 nm) and stained with uranyl acetate/lead citrate, then observed by TEM.

Item type: Digital
Imaging mode: CM12 TEM equipped with AMT digital camera

• Drosophila melanogaster

• L1 larval brain

• data
• image

• No linguistic content; Not applicable

Samplenumber: 50729

Source data

• Source Record in the Cell Image Library: https://doi.org/10.7295/W9CIL50729

Reference

• Journal article "Mitochondria-enriched protrusions are associated with brain and intestinal stem cells in Drosophila": https://doi.org/10.1038/s42003-019-0671-4

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2025-01-30