Cell Image Library (2021). CIL:38916, thalamus. In Cell Image Library. UC San Diego Library Digital Collections. Dataset. https://doi.org/10.6075/J0J38RCH

This confocal image of normal brain tissue from the thalamus is stained with antibodies to receptors for orexin (red). Orexins are peptide hormones that help keep us awake and alert, and may also stimulate the appetite. They are produced in the hypothalamus and act through their receptors located in the nuclei of cells in many different parts of the brain. The green stain highlights the neurofilaments and the blue stain, the nuclei. A drug called orexin-RA-1 that blocks the action of these receptors is currently under development as a sleeping pill. It may also have the effect of reducing the appetite.

• 2021

B0002689 Credit MRC Toxicology Unit. Wellcome Images available under the following creative commons usage http://creativecommons.org/licenses/by-nc-nd/2.0/uk/

Item type: recorded image
Imaging mode: confocal microscopy
Parameter imaged: fluorescence emission
Source of contrast: distribution of epitope
Processing history: unprocessed raw data

• Neurofilament
• Nucleus
• Orexin peptide hormone
• Thalamus

• Orexin receptor localization

• data
• image

• No linguistic content; Not applicable

Samplenumber: 38916

Doi: https://doi.org/10.6075/J0J38RCH

Source data

• Source Record in the Cell Image Library: https://doi.org/10.7295/W9CIL38916

Other resource

• Wellcome Images: http://images.wellcome.ac.uk/

Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Public License

• UC Regents

Under copyright (US)

Use: This work is available from the UC San Diego Library. This digital copy of the work is intended to support research, teaching, and private study.

Constraint(s) on Use: This work is protected by the U.S. Copyright Law (Title 17, U.S.C.). Use of this work beyond that allowed by "fair use" or any license applied to this work requires written permission of the copyright holder(s). Responsibility for obtaining permissions and any use and distribution of this work rests exclusively with the user and not the UC San Diego Library. Inquiries can be made to the UC San Diego Library program having custody of the work.

Research Data Curation Program, UC San Diego, La Jolla, 92093-0175 (https://lib.ucsd.edu/rdcp)

2022-08-12