Schuller, S. (2021). CIL:38906, Escherichia coli, intestinal epithelial cell. In Cell Image Library. UC San Diego Library Digital Collections. Dataset. https://doi.org/10.6075/J00V8BP6

This pair of confocal micrographs demonstrates how a disease-causing strain of E. coli bacteria brings about diarrhoea by breaking down the waterproof barriers between the cells. The bacteria are seen as small red dots attached to the surface of intestinal cells making tiny pedestals out of one of the cell's own proteins (bright green). Once attached, the bacteria send signals into the cells, causing the tight junctions (blue) between the cells to break down. Water is then able to seep out between the cells into the intestine, leading to diarrhoea. The image on the left shows an early stage in the process where the tight junctions are still intact and show as continuous blue lines between the cells. The image on the right is taken later in the process, once the tight junctions have broken down. Their remnants appear as blue dots.

• 2021

• Schuller, S.

B0006873 Confocal micrograph 2007 Collection: Medical Photographic Library. Copyrighted work available under Creative Commons by-nc-nd 2.0 UK: England & Wales, see http://creativecommons.org/licenses/by-nc-nd/2.0/uk/

Preparation: chemically fixed tissue
Relation to intact cell: dispersed cells in vitro
Item type: recorded image
Imaging mode: confocal microscopy
Parameter imaged: fluorescence emission
Source of contrast: distribution of epitope
Processing history: unprocessed raw data

• Escherichia coli

• Intestinal epithelial cell
• Tight junction

• Diarrhea
• Tight junction disassembly

• data
• image

• No linguistic content; Not applicable

Samplenumber: 38906

Doi: https://doi.org/10.6075/J00V8BP6

Source data

• Source Record in the Cell Image Library: https://doi.org/10.7295/W9CIL38906

Other resource

• Wellcome Collection Images: https://wellcomecollection.org/works

Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Public License

• UC Regents

Under copyright (US)

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2022-08-12