Ellisman, Mark; Ranganathan, Rama; Deerinck, Thomas J.; Young, Stephen; Hessler, David; Terry, Robert (2021). CIL:50515, ultrastructural features in AD neurons. In Cell Image Library. UC San Diego Library Digital Collections. Dataset. https://doi.org/10.6075/J0TM78RX

We examined the structural organization of cytoskeletal components and membrane systems in neurons of well preserved biopsy material from Alzheimer’s disease (AD). Information was obtained from thin sectioned material using conventional electron microscopy and from thick sections with the high voltage electron microscope. Stereo viewing and computer assisted serial reconstruction techniques were employed to visualize three-dimensional relationships among cytoplasmic components of cortical neurons.

• 2021

• Deerinck, Thomas J.
• Ellisman, Mark
• Hessler, David
• Ranganathan, Rama
• Terry, Robert
• Young, Stephen

We observed several interesting ultrastructural features in AD neurons. These include associations of paired helical filaments (PHF) with the membranes of the nuclear envelope and with ribosomes, differences between the distribution of the Golgi apparatus in neurons containing paired helical filament bundles as compared to neurons without these filaments, and abnormalities in the microtubules of neuronal processes in the vicinity of neuritic plaques.

Item type: recorded image
Imaging mode: serial section TEM

• Homo sapiens

• Golgi apparatus part
• Nucleolus
• Nucleus
• Paired helical filaments
• Plasma membrane

• Alzheimer's disease

• data
• image
• video

• No linguistic content; Not applicable

Samplenumber: 50515

Doi: https://doi.org/10.6075/J0TM78RX

Source data

• Source Record in the Cell Image Library: https://doi.org/10.7295/W9CIL50515

Reference

• Ellisman, M., Ranganathan, R., Deerinck, T., Young, S., Terry, R., Mirra, S. (1987). Neuronal Fibrillar Cytoskeleton and Endomembrane System Organization in Alzheimer’s Disease. In: Perry, G. (eds) Alterations in the Neuronal Cytoskeleton in Alzheimer Disease. Advances in Behavioral Biology, vol 34. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1657-2_6

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2022-08-12