Bone mineral density in overweight children with and without nonalcoholic fatty liver disease
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- Restricted to UC San Diego use only
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- Creation Date
- 2011
- Creator
- Physical Description
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1 online resource ([16] p.)
- Note
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Forms part of the UCSD School of Medicine independent study projects, Class of 2011
Includes bibliographical references (p. [14]-[16])
OBJECTIVE : To evaluate bone mineral density (BMD) in obese children with and without nonalcoholic fatty liver disease (NAFLD) compared to matched controls without NAFLD, and in relation to the severity of NAFLD based upon histology. We hypothesize that children with NAFLD have lower BMD than children without NAFLD, independent of obesity. PATIENTS AND METHODS : Thirty-eight children with biopsy-proven NAFLD were matched for age, sex, race, ethnicity, height, and weight to children without evidence of NAFLD from the National Health and Nutrition Examination Survey from 1999-2004. BMD was measured by dual energy x-ray absorptiometry. Age and sex-specific BMD Z-scores were calculated and compared between children with and without NAFLD. After controlling for age, sex, race, ethnicity, and total percent body fat, the relationship between BMD and the severity of histology was analyzed in those children with NAFLD. RESULTS : Children with NAFLD had significantly (p<0.0001) lower BMD Z-scores (-1.98) than children without NAFLD (0.48). Forty-five percent of children with NAFLD had low BMD for age, compared to none of the children without NAFLD (p < 0.0001). Children with NASH had a significantly (p =0.02) lower BMD Z-score (-2.3) than children with NAFLD but not NASH (-1.1). CONCLUSIONS : NAFLD is associated with poor bone health in obese children. More severe disease is associated with lower bone mineralization. Further studies are needed to evaluate the underlying mechanisms and consequences of poor bone mineralization in children with NAFLD
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- Identifier
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Mms: 991004971879706535
- Thesis
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Thesis (M.D.)--University of California, San Diego, 2011
- Rights Holder
- Perrie Pardee
- Copyright
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Under copyright (US)
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Academic Liaison Program, University of California, San Diego, La Jolla, 92093-0175 (http://ucsd.libguides.com/c.php?g=91092&p=584168)
- Last Modified
2024-07-20