Microscopy product ID: 8166
Full resolution data file
Processed mosaic of a sagittal section through the brain of mouse model of glioma. To produce transformed cells, creGFAP mice were injected in the cortex with Ras/s.i.p53 virus and perfused after 8 weeks. In this system, GFP is introduced by the virus and expression is induced by an IRES site in the mRNA. Thus, the GFP gene is expressed whenever the virus infects a cell expressing GFAP (green). The section was immunolabeled for nestin (red) and counterstained with DAPI (blue). See MP:8011 for a section from the same brain labeled with GFAP.
- Creation Date
- Microscopy product: 2010-07-07. Project: 2007-06-01.
- Research Team Head
- Technical Details
Product type: MOSAIC. Microscopy type: MULTIPHOTON. Instrument: Nikon RTS 2000 multiphoton microscope
- Related Publications
Friedmann-Morvinski D, Bushong EA, Ke E, Soda Y, Marumoto T, Singer O, Ellisman MH, Verma IM (2012). Dedifferentiation of neurons and astrocytes by oncogenes can induce gliomas in mice. Science, 338(6110):1080-1084. doi: 10.1126/science.1226929 PMCID: PMC3595315
- Scientific Name
View formats within this collection
- Related Resource
- Rights Holder
- UC Regents
Under copyright (US)
Use: This work is available from the UC San Diego Library. This digital copy of the work is intended to support research, teaching, and private study.
Constraint(s) on Use: This work is protected by the U.S. Copyright Law (Title 17, U.S.C.). Use of this work beyond that allowed by "fair use" or any license applied to this work requires written permission of the copyright holder(s). Responsibility for obtaining permissions and any use and distribution of this work rests exclusively with the user and not the UC San Diego Library. Inquiries can be made to the UC San Diego Library program having custody of the work.
- Digital Object Made Available By
Research Data Curation Program, UC San Diego, La Jolla, 92093-0175 (https://lib.ucsd.edu/rdcp)
- Last Modified