Fawcett, Don W. (2021). CIL:13003, Cavia porcellus, polychromatophilic erythroblast. In Cell Image Library. UC San Diego Library Digital Collections. Dataset. https://doi.org/10.6075/J0639NJS

Stages of coated pit vesicle invagination during micropinocytosis. Each frame is a portion of the surface of polychromatophilic erythroblasts from guinea pig bone marrow and various stages of vesicle formation beginning with initial thickening of the membrane (1), depression (2), subsequent deepening of the pit (3), and narrowing of the neck (4). Regions of thickened membrane at sites of invagination are enhanced in this preparation by ferritin, which binds to the external region of the thickened membrane. From Fawcett (1965) J. Histochem. Cytochem. 13:75-91, reprinted with permission as Figures 54, 55, and 56 (upper, middle, lower respectively) from Chapter 2 (Specializations of the Free Surface) of 'The Cell, 2nd Ed.' by Don W. Fawcett M.D. A PDF copy of the accompanying chapter is available on the ASCB's BioEDUCATE website.

• 2021

• Fawcett, Don W.

Preparation: crosslinking-fixative fixed tissue; osmium tetroxide fixed tissue; tissue in plastic embedment
Relation to intact cell: microtome-sectioned tissue
Item type: transmission electron microscopy (TEM)
Imaging mode: illumination by electrons; detection of electrons
Parameter imaged: electron density
Source of contrast: stain with broad specificity
Visualization methods: electron-dense stain
Data qualification: Processed

• Cell Image Library Group ID: 11228

• Cavia porcellus

• Coated vesicle
• Plasma membrane
• Polychromatophilic erythroblast

• Endocytosis
• Pinocytosis

• data
• image

• No linguistic content; Not applicable

Samplenumber: 13003

Doi: https://doi.org/10.6075/J0639NJS

Source data

• Source Record in the Cell Image Library: https://doi.org/10.7295/W9CIL13003

Reference

• Fawcett DW. Surface specializations of absorbing cells. J Histochem Cytochem. 1965 Feb;13:75-91. https://doi.org/10.1177/13.2.75
• Fawcett DW. Surface specializations of absorbing cells. J Histochem Cytochem. 1965 Feb;13:75-91. https://www.ncbi.nlm.nih.gov/pubmed/?term=14293043

Other resource

• Fawcett, Don W. "The Cell." 2nd ed., W.B. Saunders, 1981, ISBN 0721635849. https://www.ascb.org/career-development/teaching/don-fawcetts-the-cell/

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2022-08-12