Brophy, Peter (2021). CIL:38962, neuron. In Cell Image Library. UC San Diego Library Digital Collections. Dataset. https://doi.org/10.6075/J0MS3RKT

Confocal micrograph of teased sciatic nerve fibers. The fibers are triple labelled for neurofilament (blue), S100 (red) and dystrophin-related protein (DRP2) (green). The S100 protein is expressed in the Schwann cells of the peripheral nervous system and in astroglial cells of the central nervous system. DRP2 is thought to be involved in membrane-cytoskeleton interactions at sites of membrane specialization and intercellular contact in various tissues. Disruption of these protein complexes are thought to be a cause of Charcot-Marie-Tooth disease. This is an inherited disease that leads to muscle-wasting.

• 2021

• Brophy, Peter

B0003732 Sciatic nerve fibres. Wellcome Images available under the following creative commons usage http://creativecommons.org/licenses/by-nc-nd/2.0/uk/

Preparation: chemically fixed tissue
Relation to intact cell: teased fibers
Item type: recorded image
Imaging mode: confocal microscopy
Parameter imaged: fluorescence emission
Source of contrast: distribution of epitope
Visualization methods: primary antibody plus labeled secondary antibody
Processing history: unprocessed raw data

• Dystrophin related protein
• Neurofilament
• Neuron
• S100
• Sciatic nerve

• Charcot-Marie-Tooth disease
• Sciatic nerve fiber organization

• data
• image

• No linguistic content; Not applicable

Samplenumber: 38962

Doi: https://doi.org/10.6075/J0MS3RKT

Source data

• Source Record in the Cell Image Library: https://doi.org/10.7295/W9CIL38962

Other resource

• Wellcome Collection Images: https://wellcomecollection.org/works

Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Public License

• UC Regents

Under copyright (US)

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2022-08-12