Platelet rich plasma for the treatment of foot and ankle pathologies
- Access
- Restricted to UC San Diego use only
- Collection
- Description
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Platelet rich plasma (PRP) is a concentrate of platelets and their bioactive factors derived from the peripheral venous blood of patients. Platelets contain factors that improve healing and tissue regeneration. PRP may offer an excellent means of non-operatively treating foot and ankle pathology. Objectives: to determine whether PRP injections improve outcomes for foot and ankle pathologies. Methods: A retrospective cohort study of patients aged ≥ 18 years diagnosed with foot or ankle pathology at University of California San Diego between January 2011 and September 2016 was performed. Patients treated with an intra- articular injection using platelet-rich plasma were categorized into the PRP group. Age and gender matching were used to select active comparator group (triamcinolone injection), and a control group (conservative treatment). Primary outcomes were patient-reported pain and function before treatment and at 12 weeks post-treatment. Pain ranged from 1-10 with higher scores corresponding to higher perception of pain. Function was determined by patient-reported activity limitations and scored according to the Amerian Orthopedic Society Foot and Society (AOFAS) ankle hindfoot scale. High scores corresponded to better function. Results: we identified four patients that met inclusion criteria for the PRP group (n=4), with age and gender matching for tiramcinolone (n=4), and control (n=4). Patients averaged 41 years old, (range 26-61), were 75% female, and had an average BMI of 28.9 (range 19.7- 44.3). The median pain score before and after treatment did not change significantly after 12 weeks in the PRP group (95% CI-1,8; P=0.19), triamcinolone group (95% CI-7, 5; P=.88), or the control group (95% CI-1,7; P=.08). Functional scores before and after treatment did no significantly change after 12 weeks in the PRP group (95% CI-3,0; P=.058), triamcinolone group (95% CI-6,3; P=.74), or the control group (95% CI-6,6; P=1). There was no significant difference in change of pain or change of function between PRP, triamcinolone, and conservative therapy (P=.31, P=.09, respectively). Conclusion: among patients with foot ankle pathologies at UCSD, PRP did not result in greater improvement in pain or function at 12 weeks post-treatment compared to triamcinolone or conservative treatment
- Creation Date
- 2018
- Creator
- Physical Description
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1 online resource (23 unnumbered pages) : illustrations, tables
- Note
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Description based on online resource; title PDF cover page (viewed May 23, 2019)
Forms part of the UC San Diego School of Medicine independent study projects, Class of 2018
Includes bibliographical references
Title provided by the cataloger
- Genre
- Topic
Format
View formats within this collection
- Language
- English
- Identifier
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Mms: 991013650289706535
- Publication
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La Jolla, California: University of California, San Diego
- Thesis
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M.D. University of California, San Diego 2018
- Rights Holder
- Paul, S.
- Copyright
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Under copyright (US)
Use: This work is available from the UC San Diego Library. This digital copy of the work is intended to support research, teaching, and private study.
Constraint(s) on Use: This work is protected by the U.S. Copyright Law (Title 17, U.S.C.). Use of this work beyond that allowed by "fair use" or any license applied to this work requires written permission of the copyright holder(s). Responsibility for obtaining permissions and any use and distribution of this work rests exclusively with the user and not the UC San Diego Library. Inquiries can be made to the UC San Diego Library program having custody of the work.
- Digital Object Made Available By
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Academic Liaison Program, UC San Diego, La Jolla, 92093-0175 (http://ucsd.libguides.com/c.php?g=91092&p=584168)
- Last Modified
2024-07-20