Use of the GALAD score for serological prediction of hepatocellular carcinoma
- Access
- Restricted to UC San Diego use only
- Collection
- Description
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Hepatocellular carcinoma (HCC) continues to be one of the leading causes of death among cancer patients worldwide. HCC occurs in well-defined at-risk populations, with curative therapy possible only for small tumors, making it a potential target for creating new screening techniques. Imaging in conjunction with serum biomarker measurements have been the hallmark of HCC diagnosis, but have shown limited use as a surveillance tool. An objective, GALAD score is a serum biomarker-based statistical model that predicts the probability of having HCC in patients with chronic liver disease. Consisting of gender, age, AFP, AFP -L3, and des-gamma-carboxyprothrombin (DCP), the GALAD model improves upon prior biomarker measurements by analyzing an AFP glycoform more specific to malignant tumors and HCC inflammation, and a prothrombin precursor able to differentiate HCC from non-malignant liver disease. This retrospective study is focused on validating the use of the GALAD model as a potential HCC screening tool. Patients at risk for HCC who had AFP total & L3% and DCP measurements will be included in the study. HCC diagnosis will be made by imaging criteria and/or pathology when available. Etiologies of liver disease including hepatitis B, hepatitis C, alcohol, and non- alcoholic fatty liver disease will also be recorded. Comparison with existing GALAD model results will help demonstrate GALAD's utility as an HCC screening tool in the San Dieog and international populations
- Creation Date
- 2018
- Creator
- Physical Description
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1 online resource (7 unnumbered pages) : color illustration
- Note
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Description based on online resource; title PDF cover page (viewed May 23, 2019)
Forms part of the UC San Diego School of Medicine independent study projects, Class of 2018
Includes bibliographical references
Title provided by the cataloger
- Genre
- Topic
Format
View formats within this collection
- Language
- English
- Identifier
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Mms: 991013649519706535
- Publication
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La Jolla, California: University of California, San Diego
- Thesis
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M.D. University of California, San Diego 2018
- Rights Holder
- Nomura, Scott
- Copyright
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Under copyright (US)
Use: This work is available from the UC San Diego Library. This digital copy of the work is intended to support research, teaching, and private study.
Constraint(s) on Use: This work is protected by the U.S. Copyright Law (Title 17, U.S.C.). Use of this work beyond that allowed by "fair use" or any license applied to this work requires written permission of the copyright holder(s). Responsibility for obtaining permissions and any use and distribution of this work rests exclusively with the user and not the UC San Diego Library. Inquiries can be made to the UC San Diego Library program having custody of the work.
- Digital Object Made Available By
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Academic Liaison Program, UC San Diego, La Jolla, 92093-0175 (http://ucsd.libguides.com/c.php?g=91092&p=584168)
- Last Modified
2024-07-19