Current state and future perspectives of adjuvant and neoadjuvant targeted therapy in the management of clinically localized renal cell carcinoma : Renal cell carcinoma adjuvant and neoadjuvant

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Renal cell carcinoma (RCC) is a common malignancy with an estimated 63,990 new cases and 14,400 deaths per year, making it the sixth and tenth most common cancer in men and women, respectively 1 . Due to the widespread use of cross-sectional imaging the incidence of RCC has increased with most cases presenting as localized disease 2 . Although stage migration has driven RCC to be diagnosed at earlier stages, the risk of recurrence remains high. As an example, with the least aggressive pathologic features a pT2 tumor has an 11% 5-year recurrence rate, which can increase to 50% as the Fuhrman grade increases 3 . Using the same pT2 tumor the 5-year recurrence rate can vary among predictive nomograms from 9% to 36% 4,5 . Extirpative surgical intervention remains the best chance for cure for localized kidney cancer, but the wide variation in recurrence opens up the possibility for adjuvant therapy to identify high risk patients and attempt to mitigate risk of disease progression. Herein we reviewed adjuvant therapies, namely the recently published phase III vascular endothelial growth factor (VEGF) tyrosine kinase inhibitor (TKI) trials. We also examine currently enrolling adjuvant therapy andimmune checkpoint inhibitor trials, which have gained popularity in multiple oncologic disciplinesa

• 2018

• Berquist, Sean W.

1 online resource (17 pages) : illustrations

Description based on online resource; title PDF cover page (viewed May 23, 2019)

Forms part of the UC San Diego School of Medicine independent study projects, Class of 2018

Includes bibliographical references

Title provided by the cataloger

• Academic Dissertations

• Dissertations, Academic--School of Medicine. (Discipline)--UCSD

• text

• English

La Jolla, California: University of California, San Diego

M.D. University of California, San Diego 2018

• Berquist, Sean W.

Under copyright (US)

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2020-10-26