CIL:37261, Bos taurus
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- Collection
- Cite This Work
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Palade, George E.; Greene, L. J. (2021). CIL:37261, Bos taurus. In Cell Image Library. UC San Diego Library Digital Collections. Dataset. https://doi.org/10.6075/J0FN14V8
- Description
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Zymogen granule fraction Calf. This study demonstrated directly that the enzyme and proenzyme composition of proteins in pancreatic juice collected from an indwelling catheter in the bovine pancreatic duct correlated exactly with the protein composition obtained from lysed purified bovine zymogen granules. Subsequent studies showed that pancreatic digestive enzymes and proenzymes were secreted from the pancreas in parallel. In other words, each granule must contain, on average, the same composition of secretory proteins. This hypothesis was later directly tested by immuno-EM localization of trypsinogen and other secretory proteins in all zymogen granules in the bovine pancreas.
Image made available by James D. Jamieson and the Department of Cell Biology, Yale University School of Medicine. - Creation Date
- 1962-11-22
- Date Issued
- 2021
- Researchers
- Methods
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Original 3.25 in. x 4 in. lantern slides were scanned at 600dpi. Original magnification x2,000.
- Technical Details
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Preparation: osmium tetroxide fixed tissue; n-butyl methacrylate embedded tissue
Relation to intact cell: microtome-sectioned tissue
Item type: recorded image
Imaging mode: transmission electron microscopy (TEM)
Parameter imaged: electron density
Source of contrast: differences in adsorption or binding of stain
Visualization methods: lead salt
Processing history: scanned negative - Series
- Scientific Name
- Anatomy
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- Language
- No linguistic content; Not applicable
- Identifier
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Samplenumber: 37261
- Related Resources
- Source Record in the Cell Image Library: https://doi.org/10.7295/W9CIL37261
- JCB. 238:2054-2070, 1963. https://www.ncbi.nlm.nih.gov/pubmed/?term=13950163
- George E. Palade EM Slide Collection: http://cushing.med.yale.edu/gsdl/cgi-bin/library?c=palade&a=d&d=DpaladeUniJ
Source data
Reference
Other resource
- License
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Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International Public License
- Rights Holder
- UC Regents
- Copyright
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Under copyright (US)
Use: This work is available from the UC San Diego Library. This digital copy of the work is intended to support research, teaching, and private study.
Constraint(s) on Use: This work is protected by the U.S. Copyright Law (Title 17, U.S.C.). Use of this work beyond that allowed by "fair use" or any license applied to this work requires written permission of the copyright holder(s). Responsibility for obtaining permissions and any use and distribution of this work rests exclusively with the user and not the UC San Diego Library. Inquiries can be made to the UC San Diego Library program having custody of the work.
- Digital Object Made Available By
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Research Data Curation Program, UC San Diego, La Jolla, 92093-0175 (https://lib.ucsd.edu/rdcp)
- Last Modified
2023-08-17