Kim, Keun-Young; Gutmann, David (2021). CIL:47052, Mus musculus, retinal ganglion cell. In Cell Image Library. UC San Diego Library Digital Collections. Dataset. https://doi.org/10.6075/J0Z31X7V

The purpose of this study was to investigate the progression of changes in retinal ganglion cells and optic nerve glia in neurofibromatosis-1 (NF1) genetically-engineered mice with optic glioma. RGC were counted in whole retina preparations using high-resolution, mosaic confocal microscopy following their delineation by retrograde FluoroGold labeling. Then, we found reduced RGC numbers in Nf1+/GFAPCKO mice, supporting a model in which the combination of optic nerve Nf1 heterozygosity and glial cell Nf1 loss results in disrupted axonal-glial relationships, subsequently culminating in the degeneration of optic nerve axons and loss of their parent RGC neurons.

• 2021

• Gutmann, David
• Kim, Keun-Young

Specimen was imaged using a Olympus DSU Confocal Microscope with the Olympus 20x 1.4 NA objective.

Item type: recorded image
Imaging mode: confocal microscopy
Parameter imaged: fluorescence emission
Data qualification: Processed

• Cell Image Library Group ID: 17001

• Mus musculus

• Cell body
• Retinal ganglion cell

• data
• image

• No linguistic content; Not applicable

Samplenumber: 47052

Doi: https://doi.org/10.6075/J0Z31X7V

Source data

• Source Record in the Cell Image Library: https://doi.org/10.7295/W9CIL47052

Previous version

• Item in Cell Centered Database, UC San Diego Library Digital Collections: https://doi.org/10.6075/J0SJ1KDW

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2022-08-12