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Research based PAM50 Signature from the Women's Healthy Eating and Living (WHEL) Study

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Research based PAM50 Signature from the Women's Healthy Eating and Living (WHEL) Study

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1 digital object.

Cite This Work

Pu, Minya; Messer, Karen; Davies, Sherri R.; Vickery, Tammi L.; Pittman, Emily; Parker, Barbara A.; Ellis, Matthew J.; Flatt, Shirley W.; Marinac, Catherine R.; Nelson, Sandahl H.; Mardis, Elaine R.; Pierce, John P.; Natarajan, Loki (2023). Research based PAM50 Signature from the Women's Healthy Eating and Living (WHEL) Study. UC San Diego Library Digital Collections. https://doi.org/10.6075/J0TB172H

Description

Intrinsic molecular subtypes defined by mRNA expression of 50 genes (PAM50) are prognostic in hormone-receptor positive postmenopausal breast cancer. This study used archived 1253 FFPE breast samples with high quality reads to test the long-term prognostic value of the PAM50 signature in pre- and post-menopausal breast cancer, and to investigate if the PAM50 model could be improved by addition of other mRNAs implicated in oncogenesis. It was concluded that PAM50 intrinsic subtypes were independently prognostic for long-term breast cancer survival, irrespective of menopausal status.

Date Collected
  • 2015-07-29 to 2015-11-06
Date Issued
  • 2023
Directors
Author
Principal Investigator
Co Principal Investigators
Researchers
Data Managers
Funding

National Cancer Institute, National Institutes of Health, Awards No. R01CA166293 (KM, LN, MP, JP, BP, SF, ERM, ME, SD, TV), P30CA023100 (KM, LN, MP, EP) and F32CA220859 (CRM)

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Language
  • English
Related Resources

    Primary associated publication

    • Pu M, Messer K, Davies SR, Vickery TL, Pittman E, Parker BA, Ellis MJ, Flatt SW, Marinac CR, Nelson SH, Mardis ER, Pierce JP, Natarajan L. Research-based PAM50 signature and long-term breast cancer survival. Breast Cancer Res Treat. 2020 Jan;179(1):197-206. Epub 2019 Sep 21. PMID: 31542876; PMCID: PMC6985186. PubMed: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6985186. https://doi.org/10.1007/s10549-019-05446-y

    Source data

    Related data

    • Pierce, John P.; Faerber, Susan; Wright, Fred A.; Rock, Cheryl L.; Newman, Vicky; Flatt, Shirley W.; Kealey, Sheila; Jones, Vicky E.; Caan, Bette J.; Gold, Ellen B.; Haan, Mary; Hollenbach, Kathryn A.; Jones, Lovell A.; Marshall, James R.; Ritenbaugh, Cheryl; Stefanick, Marcia L.; Thomson, Cynthia; Wasserman, Linda; Natarajan, Loki; Thomas, Ronald G.; Gilpin, Elizabeth; Parker, Barbara A.; Greenberg, E. Robert; Al-Delaimy, Wael K.; Bardwell, Wayne A.; Carlson, Robert W.; Emond, Jennifer A.; Hajek, Richard A.; Karanja, Njeri; Madlensky, Lisa (2016). Women's Healthy Eating and Living (WHEL) Study. UC San Diego Library Digital Collections. https://doi.org/10.6075/J0H12ZXW

    Reference

    • Parker JS, Mullins M, Cheang MCU, Leung S, Voduc D, Vickery T, Davies S, Fauron C, He XP, Hu ZY, Quackenbush JF, Stijleman IJ, Palazzo J, Marron JS, Nobel AB, Mardis E, Nielsen TO, Ellis MJ, Perou CM, Bernard PS. Supervised risk predictor of breast cancer based on intrinsic subtypes. J Clin Oncol. 2009;27(8):1160–1167. PubMed: https://pubmed.ncbi.nlm.nih.gov/19204204/. https://doi.org/10.1200/jco.2008.18.1370

Research based PAM50 Signature from the Women's Healthy Eating and Living (WHEL) Study
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