Transgenerational effects of a maternal high fat diet on lipidomic profiles of male offspring in a murine model susceptible to prostate hyperproliferation

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Early life exposures during critical periods of development may have far-reaching effects on a variety of disease states in adulthood. Maternal overnutrition, specifically a high fat diet (HFD), during gestation and lactation may be deleterious to the developing fetus and predispose them to poor health outcomes later in life, an idea known as nutritional programming. A maternal HFD was previously shown to promote prostate hyperproliferation in adult male progency in a murine model. In this study, we used the same murine model, exposing dams to a HFD during pregnancy and lactation. A lipidomics approach was used to characterize how a maternal diet affects the lipid profiles of adult offspring, irrespective of offspring diet. We found that male progency, who were exposed to a HFD in utero and during suckling, exhibited alterations in levels of both fatty acids and eicosanoids in plasma and prostate tissue, in comparison to the lipid profiles of offspring of chow-fed dams. Several lipids, such as eicosapentaenoic acid (EPA), prostaglandin F2α (PGF2α), and 8-iso prostaglandin F2α (8-iso PGF2α), have been studied as potential mediators in carcinogenesis and chronic disease. This study suggests that maternal diet may have transgenerational affects on disease, potentially through altering the lipid profile of offspring

• 2018

• Sugimoto, Christine

1 online resource (15 pages) : illustrations (some color)

Description based on online resource; title PDF cover page (viewed May 23, 2019)

Forms part of the UC San Diego School of Medicine independent study projects, Class of 2018

Includes bibliographical references

Title provided by the cataloger

• Academic Dissertations

• Dissertations, Academic--School of Medicine. (Discipline)--UCSD

• text

• English

La Jolla, California: University of California, San Diego

M.D. University of California, San Diego 2018

• Sugimoto, Christine

Under copyright (US)

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2020-10-28