6350
1987-01-01 00:00:00.0
Tom Deerinck
purpose
Alzheimer reconstruction
Electron micrograph of paired helical filaments in the cell body of a 0.25 um thick section through a cortical pyramidal neuron from the brain of a patient with Alzheimer's disease. The specimen was prepared from biopsy material obtained several decades ago.
<![CDATA[http://ccdb.ucsd.edu/sand/main?event=rd&type=512r&mpid=6350]]>
Serial section image stack aligned using Midas from the IMOD package to correct for non-linear distortions. The image stack was then binned down by 4x for both the X and Y axis.
/telescience/home/CCDB_DATA_USER.portal/P1700/Experiment_3448/Subject_181/Tissue_212/Microscopy_6350/ALZ_32786.st.flip.mrc
100 KeV
26000
film
Alzheimer Neuron
.25 um
1986-03-27 00:00:00.0
6350
ALZ_32786
JEOL 100CX
TEM
SERIAL SECTION
Rama Ranganathan
Thomas J. Deerinck
Stephen J. Young
David Hessler
and Robert D. Terry
National Institutes of Health
Mark Ellisman
Alzheimer neuron reconstructions
P1700
Ellisman MH, R, Ranganathan, Deerinck TJ, Young SJ, Terry R, and Mirra S: Neuronal fibrillar cytoskeleton and endomembrane system organization in Alzheimers disease, In Alteration of the Neuronal Cytoskeleton in Aging and Dementia, GP Perry (Ed,).pp, 61-73, Plenum Publ, Corp, New York, 1988.
Neocortex pyramidal cell
brain
central nervous system
disease status
aged
male
homo sapiens
human
sapiens
cerebral cortex
ultramicrotome
.25 um
patients diagnosed with Alzheimers disease