The influence of statin therapy on liver function in patients undergoing endovascular therapy for liver cancer
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- Description
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Accumulating evidence suggests HMG-CoA reductase inhibitors, or statins, may be useful for hepatocellular carcinoma (HCC) prevention and treatment. Given the increasing interest in utilizing statins in liver disease patients, this retrospective study set out to determine whether statins impact liver function in HCC patients undergoing locoregional therapy for HCC. Routine clinical biomarkers of liver function in 50 HCC patients concurrently taking a statin at the time of endovascular therapy were compared to 100 HCC patients not taking a statin. The statin group was significantly older than the control group, but the mean pre-intervention platelet count, total bilirubin, albumin and INR values were less abnormal in the statin group as compared to the control group. The statin group demonstrated lower mean pre- intervention MELD-Na scores and FIB-4 indices compared to the control group. After intervention, the percent changes in aminotransferase levels, MELD-Na score or FIB-4 indices did not differ between groups. Overall, these data suggest statin administration at the time of locoregional therapy for HCC does not negatively impact liver function in HCC patients and might improve baseline liver function
- Creation Date
- 2018
- Creator
- Physical Description
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1 online resource (16 unnumbered pages) : illustrations
- Note
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Description based on online resource; title PDF cover page (viewed May 23, 2019)
Forms part of the UC San Diego School of Medicine independent study projects, Class of 2018
Includes bibliographical references
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- Language
- English
- Publication
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La Jolla, California: University of California, San Diego
- Thesis
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M.D. University of California, San Diego 2018
- Rights Holder
- Cochran, Rory L.
- Copyright
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Under copyright (US)
Use: This work is available from the UC San Diego Library. This digital copy of the work is intended to support research, teaching, and private study.
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- Digital Object Made Available By
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Academic Liaison Program, UC San Diego, La Jolla, 92093-0175 (http://ucsd.libguides.com/c.php?g=91092&p=584168)
- Last Modified
2020-10-28