Microscopy product ID: 3948
Virological synapse formed between HTLV-1 infected CD4+ T-cell (PBMC) and an autologous uninfected CD4+ T-cell as a target cell. These cells were stained against HTLV-1 Gag p19 matrix protein with a specific monoclonal antibody (GIN7). A large immunolabeled HTLV-1 particle is visible between the two cell membranes. See Figure 4D of Majorovits et al., 2008.
Full resolution data file
Tomographic reconstruction in MRC format. Filename = map_3948.ccp4
Animation through computed slices of tomographic reconstruction of a virilogical synapse formed between HTLV-1 infected CD4+ T-cell (PBMC) and an autologous uninfected CD4+ T-cell as a target cell. These cells were stained against HTLV-1 Gag p19 matrix protein with a specific monoclonal antibody (GIN7). A large immunolabeled HTLV-1 particle is visible between the two cell membranes.
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- Microscopy product: 2007-02-27. Project: 2004-02-02 to 2007-06-30.
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Product type: SINGLE TILT. Microscopy type: TEM. Instrument: FEI Tecnai F30 FEG
- Related Publications
Majorovits E, Nejmeddine M, Tanaka Y, Taylor GP, Fuller SD, Bangham CRM (2008). Human T-lymphotropic virus-1 visualized at the virological synapse by electron tomography. PLoS ONE 3(5):e2251. doi: 10.1371/journal.pone.0002251 PMCID: PMC2386264
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